Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) study

Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics predictors o...

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Veröffentlicht in:Scientific reports Jg. 13; H. 1; S. 9391 - 11
Hauptverfasser: Habtewold, Tesfa Dejenie, Tiles-Sar, Natalia, Liemburg, Edith J., Sandhu, Amrit Kaur, Islam, Md Atiqul, Boezen, H. Marike, Bruggeman, Richard, Alizadeh, Behrooz Z.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 09.06.2023
Nature Publishing Group
Nature Portfolio
Schlagworte:
631/208/721
692/308/174
692/308/2056
692/499
692/53/2423
692/699/476/1799
Emotional behavior
Genetic factors
Genetics
Humanities and Social Sciences
Mental disorders
multidisciplinary
Psychosis
Quality of life
Schizophrenia
Science
Science (multidisciplinary)
Siblings
ISSN:2045-2322, 2045-2322
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Zusammenfassung:Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics predictors of homogenous subgroups of the long-term course of positive and negative symptoms in SSD patients (n = 1119) and their unaffected siblings (n = 1059) in comparison to controls (n = 586). Data were collected at baseline, and after 3- and 6-year follow-ups. Group-based trajectory modeling was applied to identify latent subgroups using positive and negative symptoms or schizotypy scores. A multinomial random-effects logistic regression model was used to identify predictors of latent subgroups. Patients had decreasing, increasing, and relapsing symptoms course. Unaffected siblings and healthy controls had three to four subgroups characterized by stable, decreasing, or increasing schizotypy. PRS SCZ did not predict the latent subgroups. Baseline symptoms severity in patients, premorbid adjustment, depressive symptoms, and quality of life in siblings predicted long-term trajectories while were nonsignificant in controls. In conclusion, up to four homogenous latent subgroups of symptom course can be distinguished within patients, siblings, and controls, while non-genetic factors are the main factors associated with the latent subgroups.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-36235-9