Novel amphiphilic cationic porphyrin and its Ag(II) complex as potential anticancer agents

In the present study we have synthesized a novel amphiphilic porphyrin and its Ag(II) complex through modification of water-soluble porphyrinic structure in order to increase its lipophilicity and in turn pharmacological potency. New cationic non-symmetrical meso-substituted porphyrins were characte...

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Veröffentlicht in:	Journal of inorganic biochemistry Jg. 140; S. 94 - 103
Hauptverfasser:	Tovmasyan, Artak, Babayan, Nelli, Poghosyan, David, Margaryan, Kristine, Harutyunyan, Boris, Grigoryan, Rusanna, Sarkisyan, Natalia, Spasojevic, Ivan, Mamyan, Suren, Sahakyan, Lida, Aroutiounian, Rouben, Ghazaryan, Robert, Gasparyan, Gennadi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.11.2014
Schlagworte:	Ag porphyrin Amphiphilic porphyrin Anticancer activity Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cations Cell Line, Tumor Cytotoxicity Drug Screening Assays, Antitumor Genotoxicity Humans Photosensitizer Porphyrins - chemistry Proton Magnetic Resonance Spectroscopy Silver - chemistry Spectrometry, Mass, Electrospray Ionization Amphiphilic porphyrin KKSFBLOIWJHIPV-UHFFFAOYSA-N Anticancer activity Genotoxicity Ag porphyrin Cytotoxicity IAMUUOQNJVLXHZ-HUFLXKANSA-L Photosensitizer MPCLPUHHGBHJOC-VDCLEYLXSA-N
ISSN:	0162-0134, 1873-3344, 1873-3344
Online-Zugang:	Volltext
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