Feasibility of in vivo multi-parametric quantitative magnetic resonance imaging of the healthy sciatic nerve with a unified signal readout protocol

Magnetic resonance neurography (MRN) has been used successfully over the years to investigate the peripheral nervous system (PNS) because it allows early detection and precise localisation of neural tissue damage. However, studies demonstrating the feasibility of combining MRN with multi-parametric...

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Bibliographic Details
Published in:Scientific reports Vol. 13; no. 1; pp. 6565 - 11
Main Authors: Boonsuth, Ratthaporn, Battiston, Marco, Grussu, Francesco, Samlidou, Christina Maria, Calvi, Alberto, Samson, Rebecca S., Gandini Wheeler-Kingshott, Claudia A. M., Yiannakas, Marios C.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 21.04.2023
Nature Publishing Group
Nature Portfolio
Subjects:
631/378/1959
692/617
Central nervous system
Feasibility Studies
Humanities and Social Sciences
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy
multidisciplinary
Nervous system
Nervous tissues
Reproducibility of Results
Sciatic nerve
Sciatic Nerve - diagnostic imaging
Science
Science (multidisciplinary)
Tomography, X-Ray Computed
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Magnetic resonance neurography (MRN) has been used successfully over the years to investigate the peripheral nervous system (PNS) because it allows early detection and precise localisation of neural tissue damage. However, studies demonstrating the feasibility of combining MRN with multi-parametric quantitative magnetic resonance imaging (qMRI) methods, which provide more specific information related to nerve tissue composition and microstructural organisation, can be invaluable. The translation of emerging qMRI methods previously validated in the central nervous system to the PNS offers real potential to characterise in patients in vivo the underlying pathophysiological mechanisms involved in a plethora of conditions of the PNS. The aim of this study was to assess the feasibility of combining MRN with qMRI to measure diffusion, magnetisation transfer and relaxation properties of the healthy sciatic nerve in vivo using a unified signal readout protocol. The reproducibility of the multi-parametric qMRI protocol as well as normative qMRI measures in the healthy sciatic nerve are reported. The findings presented herein pave the way to the practical implementation of joint MRN-qMRI in future studies of pathological conditions affecting the PNS.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-33618-w