Massively parallel sequencing of mitochondrial genome in primary open angle glaucoma identifies somatically acquired mitochondrial mutations in ocular tissue

Glaucoma is a sight threatening neurodegenerative condition of the optic nerve head associated with ageing and marked by the loss of retinal ganglion cells. Mitochondrial dysfunction plays a crucial role in the pathogenesis of neurodegeneration in the most prevalent type of glaucoma: primary open an...

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Vydané v:	Scientific reports Ročník 14; číslo 1; s. 26324 - 12
Hlavní autori:	Vallabh, Neeru Amrita, Lane, Brian, Simpson, David, Fuchs, Marc, Choudhary, Anshoo, Criddle, David, Cheeseman, Robert, Willoughby, Colin
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.11.2024 Nature Publishing Group Nature Portfolio
Predmet:	631/208 631/208/2489 692/699/3161/3169 692/699/3161/3172 Aged DNA biosynthesis DNA damage DNA sequencing DNA, Mitochondrial - genetics Eye diseases Female Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Genome, Mitochondrial Genomes Glaucoma Glaucoma, Open-Angle - genetics Heteroplasmy High-Throughput Nucleotide Sequencing Humanities and Social Sciences Humans Leukocytes Male Massively parallel sequencing Middle Aged Mitochondria - genetics Mitochondrial DNA Mitochondrial genome multidisciplinary Mutation Neurodegeneration Optic nerve Pathogenesis Peripheral blood Retinal ganglion cells Science Science (multidisciplinary) Somatic mutations Tenon’s fibroblasts Whole genome sequencing Tenon’s fibroblasts Glaucoma Massively parallel sequencing Mitochondrial DNA Somatic mutations Mitochondrial genome
ISSN:	2045-2322, 2045-2322
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