Hallmarks of a genomically distinct subclass of head and neck cancer

Cancer is caused by an accumulation of somatic mutations and copy number alterations (CNAs). Besides mutations, these copy number changes are key characteristics of cancer development. Nonetheless, some tumors show hardly any CNAs, a remarkable phenomenon in oncogenesis. Head and neck squamous cell...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 9060 - 18
Main Authors:	Muijlwijk, Tara, Nauta, Irene H., van der Lee, Anabel, Grünewald, Kari J. T., Brink, Arjen, Ganzevles, Sonja H., Baatenburg de Jong, Robert J., Atanesyan, Lilit, Savola, Suvi, van de Wiel, Mark A., Peferoen, Laura A. N., Bloemena, Elisabeth, van de Ven, Rieneke, Leemans, C. René, Poell, Jos B., Brakenhoff, Ruud H.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20.10.2024 Nature Publishing Group Nature Portfolio
Subjects:	14/63 45/22 45/23 631/67/1536 631/67/1665 631/67/2329 631/67/69 Adult Aged Aged, 80 and over Cancer Carcinogens Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - pathology Copy number DNA Copy Number Variations Female Head & neck cancer Head and neck carcinoma Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Head and Neck Neoplasms - virology Human papillomavirus Humanities and Social Sciences Humans Immunoregulation Lymphocytes Lymphocytes T Male Microenvironments Middle Aged multidisciplinary Mutation Oral carcinoma Oral cavity p53 Protein Proto-Oncogene Proteins p21(ras) - genetics Science Science (multidisciplinary) Smoking Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - immunology Squamous Cell Carcinoma of Head and Neck - pathology Squamous Cell Carcinoma of Head and Neck - virology Subgroups Tumor Microenvironment - genetics Tumor Microenvironment - immunology Tumor Suppressor Protein p53 - genetics Tumorigenesis Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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