Synthesis, molecular docking and DFT analysis of novel bis-Schiff base derivatives with thiobarbituric acid for α-glucosidase inhibition assessment

A library of novel bis -Schiff base derivatives based on thiobarbituric acid has been effectively synthesized by multi-step reactions as part of our ongoing pursuit of novel anti-diabetic agents. All these derivatives were subjected to in vitro α-glucosidase inhibitory potential testing after struct...

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Bibliographic Details
Published in:	Scientific reports Vol. 14; no. 1; pp. 3419 - 14
Main Authors:	Gul, Saba, Jan, Faheem, Alam, Aftab, Shakoor, Abdul, Khan, Ajmal, AlAsmari, Abdullah F., Alasmari, Fawaz, Khan, Momin, Bo, Li
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.02.2024 Nature Publishing Group Nature Portfolio
Subjects:	631/114 631/154 631/45 639/638 Acarbose Acids bis-Schiff bases Carbohydrates Carbon Chemistry DFT Diabetes Diabetes mellitus Drugs Enzymes Ethanol Humanities and Social Sciences Hyperglycemia Libraries Materials science Molecular docking multidisciplinary NMR spectroscopy Protons Science Science (multidisciplinary) Solvents Thiobarbituric acid α-Glucosidase α-Glucosidase inhibition Schiff bases α-Glucosidase inhibition DFT Thiobarbituric acid NMR spectroscopy Molecular docking bis-Schiff bases
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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