Comparison of infection and human immune responses of two SARS-CoV-2 strains in a humanized hACE2 NIKO mouse model

The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2 have played a key role in many aspects of COVID-19 research. Here, we describe a humanized hACE2 (adenovirus expressing hACE2) NOD-SCID IL2R...

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Veröffentlicht in:	Scientific reports Jg. 13; H. 1; S. 12484 - 10
Hauptverfasser:	Yong, Kylie Su Mei, Anderson, Danielle E., Zheng, Adrian Kang Eng, Liu, Min, Tan, Sue Yee, Tan, Wilson Wei Sheng, Chen, Qingfeng, Wang, Lin-Fa
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.08.2023 Nature Publishing Group Nature Portfolio
Schlagworte:	631/250 631/326 Adenoviruses Animal models Animals Antigens Chemokines COVID-19 Cytokines Cytomegalovirus Disease Disease Models, Animal Experimental infection Experiments Global economy Histology Humanities and Social Sciences Humans Immune response Immune system Immunology Infections Inflammation Lung Lung cancer Mice Mice, Inbred NOD Mice, SCID Mice, Transgenic multidisciplinary Mutants Pandemics Pathogenesis Plasmids Proteins SARS-CoV-2 Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Spleen Stem cells Therapeutic applications
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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