A robust model for cell type-specific interindividual variation in single-cell RNA sequencing data

Single-cell RNA sequencing (scRNA-seq) has been widely used to characterize cell types based on their average gene expression profiles. However, most studies do not consider cell type-specific variation across donors. Modelling this cell type-specific inter-individual variation could help elucidate...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 5229 - 12
Main Authors:	Chen, Minhui, Dahl, Andy
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 19.06.2024 Nature Publishing Group Nature Portfolio
Subjects:	38 631/114/2415 631/1647/2217/2218 631/61/212/2019 Biology Cell differentiation Cell Differentiation - genetics Endoderm Endoderm - cytology Endoderm - metabolism Gene expression Gene Expression Profiling - methods Gene sequencing Genes Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism multidisciplinary Pluripotency Ribonucleic acid RNA RNA-Seq - methods Science Science (multidisciplinary) Sequence Analysis, RNA - methods Single-Cell Analysis - methods Statistical analysis Stem cells Transcriptome Transcriptomes Transcriptomics Variability Variation
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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