Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI

Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods focus only on participants with distinct primary continental ancestry without accommodating recently-admixed individuals with mosaic continental ancestry backgrounds for different segments of their genomes. Here, we de...

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Veröffentlicht in:	Nature communications Jg. 15; H. 1; S. 1016 - 14
Hauptverfasser:	Sun, Quan, Rowland, Bryce T., Chen, Jiawen, Mikhaylova, Anna V., Avery, Christy, Peters, Ulrike, Lundin, Jessica, Matise, Tara, Buyske, Steve, Tao, Ran, Mathias, Rasika A., Reiner, Alexander P., Auer, Paul L., Cox, Nancy J., Kooperberg, Charles, Thornton, Timothy A., Raffield, Laura M., Li, Yun
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 03.02.2024 Nature Publishing Group Nature Portfolio
Schlagworte:	45 45/43 631/114/2415 631/208/480 631/208/721 C-reactive protein Genomes Health promotion Humanities and Social Sciences Leukocytes multidisciplinary Polygenic inheritance Risk Science Science (multidisciplinary) Segments
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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