A single nucleotide polymorphism in dopamine beta hydroxylase (rs6271(C>T)) is over-represented in inflammatory bowel disease patients and reduces circulating enzyme

Inflammatory bowel diseases (IBD) are associated with altered neuronal regulation of the gastrointestinal (GI) tract and release of norepinephrine (NE). As sympathetic innervation of the GI tract modulates motility, blood flow, and immune function, changes in NE signaling may alter the risk of devel...

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Vydáno v:	PloS one Ročník 14; číslo 2; s. e0210175
Hlavní autoři:	Gonzalez-Lopez, Eugene, Kawasawa-Imamura, Yuka, Zhang, Lijun, Huang, Xuemei, Koltun, Walter A., Coates, Matthew D., Vrana, Kent E.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 28.02.2019 Public Library of Science (PLoS)
Témata:	Amino Acid Substitution Biology and Life Sciences Blood flow Cardiotonic agents Dopamine Dopamine beta-Hydroxylase - blood Dopamine beta-Hydroxylase - genetics Enzyme-linked immunosorbent assay Enzymes Exome Exome sequencing Female Gastrointestinal diseases Gastrointestinal system Genetic aspects Genetic polymorphisms Humans Hydroxylases Inflammatory bowel diseases Inflammatory Bowel Diseases - enzymology Inflammatory Bowel Diseases - genetics Male Medicine and Health Sciences Neurons Phenols (Class of compounds) Physical Sciences Polymorphism, Single Nucleotide Research and Analysis Methods Risk factors Single nucleotide polymorphisms Germany
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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