Extracellular CIRP (eCIRP) and inflammation

Cold‐inducible RNA‐binding protein (CIRP) was discovered 2 decades ago while studying the mechanism of cold stress adaptation in mammals. Since then, the role of intracellular CIRP (iCIRP) as a stress‐response protein has been extensively studied. Recently, extracellular CIRP (eCIRP) was discovered...

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Bibliographic Details
Published in:	Journal of leukocyte biology Vol. 106; no. 1; pp. 133 - 146
Main Authors:	Aziz, Monowar, Brenner, Max, Wang, Ping
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.07.2019
Subjects:	Alarmins - physiology ALI Animals CIRP Cytosol Damage patterns DAMP Dendritic cells DNA damage eCIRP Endoplasmic reticulum Endoplasmic Reticulum Stress Endothelial cells hemorrhage Humans Inflammasomes Inflammation Inflammation - drug therapy Inflammation - etiology Inflammation Mediators - physiology Inflammatory diseases Ischemia ischemia/reperfusion Leukocytes (neutrophilic) Lymphocytes macrophage Macrophages Mitochondrial DNA Necroptosis neutrophils Neutrophils - physiology NF-κB protein Proteins Pyroptosis Reperfusion RNA-binding protein RNA-Binding Proteins - antagonists & inhibitors RNA-Binding Proteins - physiology Sepsis Signal Transduction Therapeutic applications Therapeutic targets TLR4 protein Toll-Like Receptor 4 - physiology Toll-like receptors Translocation ischemia/reperfusion inflammation eCIRP macrophage CIRP neutrophils ALI sepsis DAMP hemorrhage
ISSN:	0741-5400, 1938-3673, 1938-3673
Online Access:	Get full text
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