Is intravoxel incoherent motion magnetic resonance imaging useful for predicting hepatocellular cancer recurrence and invasion of the peritumoral zone after transarterial chemoembolization?

ABSTRACT Purpose: We evaluated the potential role of intravoxel incoherent motion (IVIM) in predicting the therapeutic response and peritumoral invasion in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). Materials and Methods: We enrolled 47 patients...

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Vydané v:	Journal of cancer research and therapeutics Ročník 20; číslo 2; s. 584 - 591
Hlavní autori:	Zhao, Xinyao, Wen, Qingqing, Wang, Junying, Dou, Weiqiang, Zhang, Guowei, Shi, Hao
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	India Wolters Kluwer - Medknow 01.04.2024 Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd
Vydanie:	2
Predmet:	Adult Aged Cancer Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy Care and treatment Chemoembolization Chemoembolization, Therapeutic - methods Diagnosis Diffusion Magnetic Resonance Imaging - methods Diseases Female Health aspects Hepatoma Humans Liver Liver - diagnostic imaging Liver - pathology Liver cancer Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Liver Neoplasms - therapy Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Methods Middle Aged Neoplasm Invasiveness Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - therapy Original Article Prognosis Relapse Retrospective Studies ROC Curve China United States Wisconsin recurrence peritumoral invasion Hepatocellular carcinoma transarterial chemoembolization intravoxel incoherent motion
ISSN:	0973-1482, 1998-4138, 1998-4138
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Shrnutí:	ABSTRACT Purpose: We evaluated the potential role of intravoxel incoherent motion (IVIM) in predicting the therapeutic response and peritumoral invasion in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). Materials and Methods: We enrolled 47 patients previously treated with TACE between January 2018 and December 2021. We evaluated the IVIM-derived metrics [apparent diffusion coefficient (ADC), D, D*, f] in the TACE-treated, peritumoral, and parenchymal areas of the liver. Results: The ADCtace and Dtace values (1.13 ± 0.22 × 10−3 m2/s vs 0.95 ± 0.13 × 10−3 mm2/s, 1.28 ± 0.27 × 10−3 mm2/s vs 1.07 ± 0.3 × 10−3 mm2/s, P < 0.05) were higher in the non-progressing groups than in the progressing groups in the TACE-treated areas. Dpt represented the D values in the peritumoral area, which can distinguish between the progressive and non-progressive groups with an AUC of 0.73. The Dstd values, which represent the D values in the peritumoral area normalized by the D values in the liver parenchyma in the non-progressing groups (1.10 ± 0.14 × 10−3 mm2/s), were higher than those of the progressing groups (0.93 ± 0.17 × 10−3 mm2/s). Conclusion: The ADCtace, Dtace, Dpt, and Dstd values reflect the changes in the microstructure of the progressive and non-progressive groups after TACE treatment, showing robust diagnostic performances in predicting the therapeutic response and peritumoral invasion.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0973-1482 1998-4138 1998-4138
DOI:	10.4103/jcrt.jcrt_1582_23