Is intravoxel incoherent motion magnetic resonance imaging useful for predicting hepatocellular cancer recurrence and invasion of the peritumoral zone after transarterial chemoembolization?

ABSTRACT Purpose: We evaluated the potential role of intravoxel incoherent motion (IVIM) in predicting the therapeutic response and peritumoral invasion in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). Materials and Methods: We enrolled 47 patients...

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Veröffentlicht in:Journal of cancer research and therapeutics Jg. 20; H. 2; S. 584 - 591
Hauptverfasser: Zhao, Xinyao, Wen, Qingqing, Wang, Junying, Dou, Weiqiang, Zhang, Guowei, Shi, Hao
Format: Journal Article
Sprache:Englisch
Veröffentlicht: India Wolters Kluwer - Medknow 01.04.2024
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Ausgabe:2
Schlagworte:
Adult
Aged
Cancer
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Care and treatment
Chemoembolization
Chemoembolization, Therapeutic - methods
Diagnosis
Diffusion Magnetic Resonance Imaging - methods
Diseases
Female
Health aspects
Hepatoma
Humans
Liver
Liver - diagnostic imaging
Liver - pathology
Liver cancer
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Methods
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - therapy
Original Article
Prognosis
Relapse
Retrospective Studies
ROC Curve
China
United States
Wisconsin
recurrence
peritumoral invasion
Hepatocellular carcinoma
transarterial chemoembolization
intravoxel incoherent motion
ISSN:0973-1482, 1998-4138, 1998-4138
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Zusammenfassung:ABSTRACT Purpose: We evaluated the potential role of intravoxel incoherent motion (IVIM) in predicting the therapeutic response and peritumoral invasion in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). Materials and Methods: We enrolled 47 patients previously treated with TACE between January 2018 and December 2021. We evaluated the IVIM-derived metrics [apparent diffusion coefficient (ADC), D, D*, f] in the TACE-treated, peritumoral, and parenchymal areas of the liver. Results: The ADCtace and Dtace values (1.13 ± 0.22 × 10−3 m2/s vs 0.95 ± 0.13 × 10−3 mm2/s, 1.28 ± 0.27 × 10−3 mm2/s vs 1.07 ± 0.3 × 10−3 mm2/s, P < 0.05) were higher in the non-progressing groups than in the progressing groups in the TACE-treated areas. Dpt represented the D values in the peritumoral area, which can distinguish between the progressive and non-progressive groups with an AUC of 0.73. The Dstd values, which represent the D values in the peritumoral area normalized by the D values in the liver parenchyma in the non-progressing groups (1.10 ± 0.14 × 10−3 mm2/s), were higher than those of the progressing groups (0.93 ± 0.17 × 10−3 mm2/s). Conclusion: The ADCtace, Dtace, Dpt, and Dstd values reflect the changes in the microstructure of the progressive and non-progressive groups after TACE treatment, showing robust diagnostic performances in predicting the therapeutic response and peritumoral invasion.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0973-1482
1998-4138
1998-4138
DOI:10.4103/jcrt.jcrt_1582_23