SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells

During development, it is unclear if lineage-fated cells derive from multilineage-primed progenitors and whether active mechanisms operate to restrict cell fate. Here we investigate how mesoderm specifies into blood-fated cells. We document temporally restricted co-expression of blood ( Scl/Tal1 ),...

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Bibliographic Details
Published in:	Nature communications Vol. 9; no. 1; pp. 5375 - 17
Main Authors:	Chagraoui, Hedia, Kristiansen, Maiken S., Ruiz, Juan Pablo, Serra-Barros, Ana, Richter, Johanna, Hall-Ponselé, Elisa, Gray, Nicki, Waithe, Dominic, Clark, Kevin, Hublitz, Philip, Repapi, Emmanouela, Otto, Georg, Sopp, Paul, Taylor, Stephen, Thongjuea, Supat, Vyas, Paresh, Porcher, Catherine
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.12.2018 Nature Publishing Group Nature Portfolio
Subjects:	14 14/19 45 45/100 45/15 45/41 45/47 45/91 631/136/232 631/337/176/2016 631/337/572 Animals Blood Cell Differentiation - physiology Cell fate Cell Line Cell Lineage - physiology Cell Separation - methods Embryo, Mammalian Embryonic growth stage Flow Cytometry - methods Gene expression Gene Expression Regulation, Developmental - physiology Gene silencing Genomes Heart Histone Code - physiology Humanities and Social Sciences Mesoderm Mesoderm - cytology Mesoderm - physiology Mice Mouse Embryonic Stem Cells multidisciplinary Nuclear Proteins - genetics Nuclear Proteins - metabolism Phenotypes Polycomb group proteins Polycomb Repressive Complex 1 - metabolism Polycomb-Group Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism RNA, Small Interfering - metabolism Science Science (multidisciplinary) Specifications T-Cell Acute Lymphocytic Leukemia Protein 1 - genetics T-Cell Acute Lymphocytic Leukemia Protein 1 - metabolism Transcription factors Transcription Factors - genetics Transcription Factors - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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