A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states

Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbations in human induced pluripotent stem cell-derived...

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Veröffentlicht in:	Nature neuroscience Jg. 25; H. 9; S. 1149 - 1162
Hauptverfasser:	Dräger, Nina M, Sattler, Sydney M, Huang, Cindy Tzu-Ling, Teter, Olivia M, Leng, Kun, Hashemi, Sayed Hadi, Hong, Jason, Aviles, Giovanni, Clelland, Claire D, Zhan, Lihong, Udeochu, Joe C, Kodama, Lay, Singleton, Andrew B, Nalls, Mike A, Ichida, Justin, Ward, Michael E, Faghri, Faraz, Gan, Li, Kampmann, Martin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Nature Publishing Group 01.09.2022
Schlagworte:	Brain - metabolism Clustered Regularly Interspaced Short Palindromic Repeats - genetics Colony-stimulating factor CRISPR Disease Gene sequencing Genes Genomes Humans Induced Pluripotent Stem Cells - metabolism Macrophage colony-stimulating factor Microglia Microglia - metabolism Neurodegeneration Neurological diseases Osteopontin Perturbation Phagocytosis Phagocytosis - genetics Pluripotency Stem cells Therapeutic targets Transcription activation Transcription factors
ISSN:	1097-6256, 1546-1726, 1546-1726
Online-Zugang:	Volltext
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