The lingering mysteries of metastatic recurrence in breast cancer
Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic disease typically manifests after a protracted period of undetectable disease following surgery or systemic therapy, owing to relapse or recurre...
Uloženo v:
| Vydáno v: | British journal of cancer Ročník 124; číslo 1; s. 13 - 26 |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
Nature Publishing Group UK
05.01.2021
Nature Publishing Group |
| Témata: | |
| ISSN: | 0007-0920, 1532-1827, 1532-1827 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic disease typically manifests after a protracted period of undetectable disease following surgery or systemic therapy, owing to relapse or recurrence. In the case of breast cancer, metastatic relapse can occur months to decades after initial diagnosis and treatment. In this review, we provide an overview of the known key factors that influence metastatic recurrence, with the goal of highlighting the critical unanswered questions that still need to be addressed to make a difference in the mortality of breast cancer patients. |
|---|---|
| AbstractList | Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic disease typically manifests after a protracted period of undetectable disease following surgery or systemic therapy, owing to relapse or recurrence. In the case of breast cancer, metastatic relapse can occur months to decades after initial diagnosis and treatment. In this review, we provide an overview of the known key factors that influence metastatic recurrence, with the goal of highlighting the critical unanswered questions that still need to be addressed to make a difference in the mortality of breast cancer patients. Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic disease typically manifests after a protracted period of undetectable disease following surgery or systemic therapy, owing to relapse or recurrence. In the case of breast cancer, metastatic relapse can occur months to decades after initial diagnosis and treatment. In this review, we provide an overview of the known key factors that influence metastatic recurrence, with the goal of highlighting the critical unanswered questions that still need to be addressed to make a difference in the mortality of breast cancer patients. Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic disease typically manifests after a protracted period of undetectable disease following surgery or systemic therapy, owing to relapse or recurrence. In the case of breast cancer, metastatic relapse can occur months to decades after initial diagnosis and treatment. In this review, we provide an overview of the known key factors that influence metastatic recurrence, with the goal of highlighting the critical unanswered questions that still need to be addressed to make a difference in the mortality of breast cancer patients.Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic disease typically manifests after a protracted period of undetectable disease following surgery or systemic therapy, owing to relapse or recurrence. In the case of breast cancer, metastatic relapse can occur months to decades after initial diagnosis and treatment. In this review, we provide an overview of the known key factors that influence metastatic recurrence, with the goal of highlighting the critical unanswered questions that still need to be addressed to make a difference in the mortality of breast cancer patients. |
| Author | Varley, Katherine E. Riggio, Alessandra I. Welm, Alana L. |
| Author_xml | – sequence: 1 givenname: Alessandra I. surname: Riggio fullname: Riggio, Alessandra I. organization: Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah – sequence: 2 givenname: Katherine E. surname: Varley fullname: Varley, Katherine E. organization: Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah – sequence: 3 givenname: Alana L. orcidid: 0000-0002-1412-1351 surname: Welm fullname: Welm, Alana L. email: alana.welm@hci.utah.edu organization: Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33239679$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UU1PFTEUbQhGHugfcGEmccNm9PZj-rExIUTUhMQNrptO5w6UzLTPdsaEf28fD0RZsGl7c885OT3nmBzGFJGQdxQ-UuD6UxFUUNkCgxYolbQVB2RDO85aqpk6JBsAUC0YBkfkuJTbOhrQ6jU54pxxI5XZkLOrG2ymEK8x16OZ78pSX1iaNDYzLq4sbgm-yejXnDF6bEJs-ox10XhX5_yGvBrdVPDtw31Cfl58uTr_1l7--Pr9_Oyy9Z2ApR2G3nDWGy-qoUEAMK4977hmTPDOSS21HqRkRvTg0RgcB5Bq9E6xwXVe8RPyea-7XfsZB49xyW6y2xxml-9scsH-v4nhxl6n31apmobiVeD0QSCnXyuWxc6heJwmFzGtxTIhhYROA63QD8-gt2nNsX6vopQwBrhgFfX-X0d_rTymWwF6D_A5lZJxtD7s8kw7g2GyFOyuSLsv0tYi7X2RVlQqe0Z9VH-RxPekss33lT7ZfoH1B4CorzQ |
| CitedBy_id | crossref_primary_10_3390_pharmaceutics15112627 crossref_primary_10_1016_j_biomaterials_2024_123020 crossref_primary_10_1016_j_bios_2024_116801 crossref_primary_10_1016_j_tranon_2024_102149 crossref_primary_10_2147_IJGM_S328184 crossref_primary_10_1007_s12094_022_02889_6 crossref_primary_10_2174_0113816128272489231124095922 crossref_primary_10_1007_s00432_023_05337_2 crossref_primary_10_1016_j_csbj_2023_03_036 crossref_primary_10_3390_cells12010064 crossref_primary_10_1038_s41523_023_00564_9 crossref_primary_10_3390_cells10102673 crossref_primary_10_1016_j_breast_2024_103741 crossref_primary_10_3390_ijms23063080 crossref_primary_10_7759_cureus_55712 crossref_primary_10_3390_biom12121818 crossref_primary_10_1088_1361_6528_ad5681 crossref_primary_10_1109_ACCESS_2025_3573808 crossref_primary_10_3389_fphar_2024_1381478 crossref_primary_10_3390_biom11071015 crossref_primary_10_1038_s41598_023_32631_3 crossref_primary_10_1007_s12038_023_00386_8 crossref_primary_10_1016_j_yexcr_2023_113538 crossref_primary_10_1016_j_hlife_2024_01_003 crossref_primary_10_1186_s12935_024_03541_9 crossref_primary_10_3390_biomedicines10081908 crossref_primary_10_1021_acscentsci_1c01024 crossref_primary_10_3390_jmp3040019 crossref_primary_10_1126_sciadv_adt0341 crossref_primary_10_1007_s10555_023_10163_6 crossref_primary_10_1093_neuonc_noae169 crossref_primary_10_1002_dvg_23552 crossref_primary_10_2147_BCTT_S458036 crossref_primary_10_1021_acsomega_5c04484 crossref_primary_10_1016_j_cpccr_2022_100191 crossref_primary_10_1016_j_biocel_2022_106156 crossref_primary_10_2147_BCTT_S400974 crossref_primary_10_1038_s41416_021_01401_1 crossref_primary_10_32604_or_2022_027547 crossref_primary_10_1002_smll_202504778 crossref_primary_10_3390_ph16111562 crossref_primary_10_1016_j_phymed_2025_157017 crossref_primary_10_14814_phy2_15497 crossref_primary_10_3389_fonc_2024_1371342 crossref_primary_10_1016_j_indcrop_2025_121572 crossref_primary_10_1080_03639045_2025_2509861 crossref_primary_10_1021_acs_jcim_4c01652 crossref_primary_10_3889_oamjms_2023_11288 crossref_primary_10_1038_s41598_025_92594_5 crossref_primary_10_1002_anbr_202500038 crossref_primary_10_3390_ijms23116271 crossref_primary_10_1016_j_clnu_2022_09_016 crossref_primary_10_3390_ijms23169371 crossref_primary_10_1017_erm_2022_4 crossref_primary_10_1007_s00259_024_06632_x crossref_primary_10_1016_j_apsb_2022_12_004 crossref_primary_10_1016_j_bcp_2021_114787 crossref_primary_10_1186_s12964_023_01446_0 crossref_primary_10_3390_cancers15030568 crossref_primary_10_1016_j_bioactmat_2024_09_008 crossref_primary_10_1038_s41417_021_00419_0 crossref_primary_10_1080_17435889_2024_2382083 crossref_primary_10_1016_j_jff_2024_106224 crossref_primary_10_1002_adbi_202400441 crossref_primary_10_1038_s41598_022_14392_7 crossref_primary_10_1007_s13668_023_00495_8 crossref_primary_10_1080_14656566_2024_2337261 crossref_primary_10_3390_biology13090724 crossref_primary_10_1016_j_critrevonc_2024_104389 crossref_primary_10_2340_1651_226X_2025_43143 crossref_primary_10_3389_fimmu_2022_946468 crossref_primary_10_1007_s12672_025_02604_1 crossref_primary_10_1016_j_canlet_2024_217310 crossref_primary_10_1016_j_ajpath_2024_02_013 crossref_primary_10_1016_j_ajpath_2023_05_018 crossref_primary_10_1007_s12609_024_00567_w crossref_primary_10_1177_15330338241292226 crossref_primary_10_3390_healthcare10101901 crossref_primary_10_1186_s12885_025_13875_w crossref_primary_10_3390_ma15010179 crossref_primary_10_1159_000545264 crossref_primary_10_1097_GOX_0000000000005385 crossref_primary_10_1158_0008_5472_CAN_22_2717 crossref_primary_10_3389_fphar_2025_1545300 crossref_primary_10_1016_j_bspc_2025_108157 crossref_primary_10_1038_s41419_024_06694_7 crossref_primary_10_3390_cancers14040976 crossref_primary_10_1002_adhm_202304374 crossref_primary_10_1177_00368504251362350 crossref_primary_10_3390_cancers16173057 crossref_primary_10_1002_cbdv_202100872 crossref_primary_10_1007_s10876_023_02404_z crossref_primary_10_14309_crj_0000000000001582 crossref_primary_10_3389_fcell_2024_1478478 crossref_primary_10_1007_s12672_025_02198_8 crossref_primary_10_1021_acsami_4c13535 crossref_primary_10_1038_s41419_025_07885_6 crossref_primary_10_3390_biomedicines9111578 crossref_primary_10_1016_j_apsusc_2025_163971 crossref_primary_10_7759_cureus_25555 crossref_primary_10_1007_s10549_024_07479_4 crossref_primary_10_1038_s41598_025_10186_9 crossref_primary_10_3390_cells12081182 crossref_primary_10_1039_D4BM00342J crossref_primary_10_1016_j_mattod_2023_03_025 crossref_primary_10_1186_s12935_025_03822_x crossref_primary_10_1016_j_ejmech_2023_115422 crossref_primary_10_3389_fmolb_2024_1361377 crossref_primary_10_3390_ijms241813930 crossref_primary_10_1007_s11427_022_2329_7 crossref_primary_10_1186_s13036_024_00408_5 crossref_primary_10_1016_j_bioorg_2025_108582 crossref_primary_10_1016_j_cej_2025_165522 crossref_primary_10_1186_s12935_023_03206_z crossref_primary_10_1002_advs_202404853 crossref_primary_10_3390_ijms22137057 crossref_primary_10_1515_epoly_2023_0064 crossref_primary_10_1039_D3NR06672J crossref_primary_10_3390_cancers14184397 crossref_primary_10_1038_s41598_024_63136_2 crossref_primary_10_3389_fimmu_2024_1385484 crossref_primary_10_21769_BioProtoc_5454 crossref_primary_10_1155_2022_7177192 crossref_primary_10_1109_TNB_2023_3274737 crossref_primary_10_3390_ijms23179758 crossref_primary_10_1016_j_jiec_2024_09_057 crossref_primary_10_1038_s41698_024_00751_2 crossref_primary_10_3390_biomedicines11082300 crossref_primary_10_1002_adhm_202202622 crossref_primary_10_1016_j_gene_2022_146504 crossref_primary_10_1002_jum_16449 crossref_primary_10_1016_j_ijbiomac_2023_123792 crossref_primary_10_3389_fcell_2022_993915 crossref_primary_10_3389_fonc_2025_1573163 crossref_primary_10_3390_biology12060777 crossref_primary_10_3390_genes14091768 crossref_primary_10_1007_s10585_022_10162_x crossref_primary_10_1016_j_cej_2024_151601 crossref_primary_10_1007_s12282_022_01413_6 crossref_primary_10_1007_s12291_023_01129_0 crossref_primary_10_1016_j_redox_2025_103845 crossref_primary_10_1186_s12943_025_02338_2 crossref_primary_10_3390_app11104527 crossref_primary_10_3390_cells10061377 crossref_primary_10_1038_s41598_023_30585_0 crossref_primary_10_1038_s41598_025_06090_x crossref_primary_10_1097_JCMA_0000000000000781 crossref_primary_10_1007_s11626_023_00823_w crossref_primary_10_1016_j_ctarc_2022_100677 crossref_primary_10_3390_ijms24032494 crossref_primary_10_1039_D2RA07863E crossref_primary_10_3389_fmolb_2021_668534 crossref_primary_10_1016_j_bbcan_2024_189163 crossref_primary_10_1016_j_ctarc_2022_100670 crossref_primary_10_3390_ijms24044226 crossref_primary_10_1038_s44319_025_00520_7 crossref_primary_10_1007_s12032_022_01728_6 crossref_primary_10_55905_cuadv17n7_071 crossref_primary_10_3390_vaccines13040429 crossref_primary_10_1242_dmm_048801 crossref_primary_10_1038_s41388_025_03529_3 crossref_primary_10_1038_s41419_023_05718_y crossref_primary_10_1016_j_pharmthera_2022_108280 crossref_primary_10_1002_1878_0261_70015 crossref_primary_10_3390_ijms241311149 crossref_primary_10_1007_s10876_023_02497_6 crossref_primary_10_1038_s41389_023_00479_x crossref_primary_10_34133_bmr_0008 crossref_primary_10_1007_s00520_023_07928_8 crossref_primary_10_1242_jcs_240135 crossref_primary_10_3390_diagnostics12092094 crossref_primary_10_17116_onkolog20241304142 crossref_primary_10_1007_s40944_024_00864_3 crossref_primary_10_1007_s10517_025_06336_8 crossref_primary_10_1177_17588359231205848 crossref_primary_10_1186_s12885_023_11588_6 crossref_primary_10_1186_s12957_025_03874_3 crossref_primary_10_4274_balkanmedj_galenos_2024_2024_8_49 crossref_primary_10_1016_j_jconrel_2025_01_051 crossref_primary_10_1016_j_isci_2024_111589 crossref_primary_10_3390_cancers13061385 crossref_primary_10_1016_j_mtbio_2025_101916 crossref_primary_10_1016_j_ctrv_2023_102521 crossref_primary_10_1038_s41598_023_31557_0 crossref_primary_10_1016_j_heliyon_2024_e33195 crossref_primary_10_1073_pnas_2215553120 crossref_primary_10_2174_0109298673286234240123100955 crossref_primary_10_1002_adfm_202307074 crossref_primary_10_1038_s41416_022_01869_5 crossref_primary_10_3389_fonc_2022_965136 crossref_primary_10_1186_s12645_024_00294_y crossref_primary_10_3390_cells12162076 crossref_primary_10_1038_s44341_025_00018_2 crossref_primary_10_3389_fonc_2024_1482223 crossref_primary_10_1038_s41416_023_02340_9 crossref_primary_10_3390_healthcare13020166 crossref_primary_10_1007_s44272_025_00030_6 crossref_primary_10_12991_jrespharm_1628559 crossref_primary_10_3390_cells11193165 crossref_primary_10_3389_fcell_2022_929893 crossref_primary_10_3390_cancers14133287 crossref_primary_10_3390_biomedicines12112625 crossref_primary_10_1186_s12905_023_02588_6 crossref_primary_10_1007_s00210_025_04251_3 crossref_primary_10_1007_s12094_024_03754_4 crossref_primary_10_1016_j_advms_2024_02_006 crossref_primary_10_1016_j_intimp_2024_113207 crossref_primary_10_1007_s12032_024_02481_8 crossref_primary_10_1186_s12935_025_03854_3 crossref_primary_10_1088_1742_6596_2970_1_012009 crossref_primary_10_1186_s12880_024_01361_x crossref_primary_10_1186_s12935_023_02972_0 crossref_primary_10_1016_j_lungcan_2025_108495 crossref_primary_10_3390_antiox12030586 crossref_primary_10_3390_molecules28030987 crossref_primary_10_1016_j_ijpharm_2025_125213 crossref_primary_10_1186_s13046_022_02329_x crossref_primary_10_1038_s12276_024_01181_7 crossref_primary_10_1186_s13058_024_01865_y crossref_primary_10_32604_or_2024_052133 crossref_primary_10_3389_fonc_2023_1111570 crossref_primary_10_1016_j_clbc_2023_03_007 crossref_primary_10_1007_s44164_023_00055_y crossref_primary_10_1186_s12912_023_01184_1 crossref_primary_10_3390_biomedicines12030691 crossref_primary_10_1177_11779322231224187 crossref_primary_10_3389_fonc_2021_802592 crossref_primary_10_1007_s12262_022_03535_9 crossref_primary_10_1038_s41416_023_02243_9 crossref_primary_10_3390_medicina58101380 crossref_primary_10_1097_JS9_0000000000002530 crossref_primary_10_3390_cancers17132134 crossref_primary_10_1111_php_14100 crossref_primary_10_3390_diagnostics13213338 crossref_primary_10_1016_j_bbagen_2024_130577 crossref_primary_10_1148_radiol_240021 crossref_primary_10_1080_01635581_2024_2348217 crossref_primary_10_1016_j_prp_2023_154482 crossref_primary_10_1016_j_semcancer_2023_09_001 crossref_primary_10_3389_fonc_2025_1595913 crossref_primary_10_1080_1061186X_2025_2468750 crossref_primary_10_1186_s12885_021_08470_8 crossref_primary_10_1016_j_seminoncol_2025_152386 crossref_primary_10_1016_j_jddst_2021_102957 crossref_primary_10_1007_s13205_022_03140_3 crossref_primary_10_3390_ijms26020693 crossref_primary_10_1016_j_lfs_2025_123562 crossref_primary_10_1007_s12094_024_03619_w crossref_primary_10_1016_j_bbcan_2025_189440 crossref_primary_10_1055_s_0043_1772183 crossref_primary_10_1002_adma_202419120 crossref_primary_10_25122_jml_2022_0189 crossref_primary_10_3390_ijms222413367 crossref_primary_10_1016_j_ebiom_2022_104169 crossref_primary_10_25122_jml_2021_0354 crossref_primary_10_1016_j_isci_2023_108322 crossref_primary_10_1038_s41392_024_01779_3 crossref_primary_10_1177_11782234221086728 crossref_primary_10_3389_fimmu_2024_1276306 crossref_primary_10_1038_s41598_022_07675_6 crossref_primary_10_1021_jacs_5c04234 crossref_primary_10_1016_j_humgen_2024_201272 crossref_primary_10_1002_jemt_24831 crossref_primary_10_3390_ijms242417488 crossref_primary_10_3389_fonc_2023_1188310 crossref_primary_10_3390_cancers13184679 crossref_primary_10_1016_j_semcancer_2022_12_010 crossref_primary_10_3390_biom15091308 crossref_primary_10_1002_ptr_7948 crossref_primary_10_1111_jog_15931 crossref_primary_10_1021_acs_jproteome_5c00386 crossref_primary_10_3390_cells12050720 crossref_primary_10_3390_jpm13101498 crossref_primary_10_1016_j_semcancer_2023_06_007 crossref_primary_10_1186_s12943_022_01577_x crossref_primary_10_3390_ijms241713407 crossref_primary_10_3390_ijms231911595 crossref_primary_10_1016_j_lfs_2023_121997 crossref_primary_10_1016_j_ijbiomac_2024_131075 crossref_primary_10_1038_s41416_024_02804_6 crossref_primary_10_12677_MD_2023_133052 crossref_primary_10_1109_ACCESS_2024_3424526 crossref_primary_10_1186_s12885_024_13254_x crossref_primary_10_1007_s12672_024_01063_4 crossref_primary_10_3389_fcell_2023_1222809 crossref_primary_10_3389_fmedt_2022_893056 crossref_primary_10_3389_fonc_2023_1199105 crossref_primary_10_1016_j_pharmr_2025_100087 crossref_primary_10_3390_cancers13153725 crossref_primary_10_1007_s12032_024_02378_6 crossref_primary_10_1016_j_fct_2023_114102 crossref_primary_10_3389_fonc_2025_1494723 crossref_primary_10_1055_s_0045_1809376 crossref_primary_10_1007_s10549_025_07801_8 crossref_primary_10_1177_17588359231178125 crossref_primary_10_1002_adbi_202200114 crossref_primary_10_3389_fphar_2024_1339580 crossref_primary_10_3390_cancers13184699 crossref_primary_10_1016_j_critrevonc_2023_104060 crossref_primary_10_1186_s12967_025_06700_2 crossref_primary_10_1007_s11596_025_00081_9 crossref_primary_10_7759_cureus_19820 crossref_primary_10_1016_j_semcancer_2021_02_004 crossref_primary_10_1186_s13058_025_01982_2 crossref_primary_10_1007_s00262_025_04095_z crossref_primary_10_1007_s12609_025_00585_2 crossref_primary_10_1016_j_jep_2024_117837 crossref_primary_10_1158_2326_6066_CIR_23_0718 crossref_primary_10_1177_11782234241288671 crossref_primary_10_1016_j_pharmthera_2023_108522 crossref_primary_10_1053_j_semdp_2022_04_002 crossref_primary_10_3164_jcbn_23_131 crossref_primary_10_3389_fonc_2024_1490073 crossref_primary_10_1016_j_procs_2021_09_044 crossref_primary_10_1186_s12889_025_24036_w crossref_primary_10_3389_fonc_2023_1104594 crossref_primary_10_1097_ANS_0000000000000578 crossref_primary_10_1172_JCI183971 crossref_primary_10_3389_fonc_2024_1419808 crossref_primary_10_1002_cam4_70274 crossref_primary_10_1007_s10585_024_10289_z crossref_primary_10_1186_s12967_024_05689_4 crossref_primary_10_3897_pharmacia_71_e117997 crossref_primary_10_3390_cancers15153960 crossref_primary_10_1371_journal_pone_0307283 crossref_primary_10_1002_iid3_876 crossref_primary_10_1016_j_celrep_2025_116042 crossref_primary_10_2147_CMAR_S449777 crossref_primary_10_32604_biocell_2023_028516 crossref_primary_10_3389_fimmu_2023_1194931 crossref_primary_10_7759_cureus_92801 crossref_primary_10_1088_2043_6262_ad9f49 crossref_primary_10_1016_j_modpat_2024_100652 crossref_primary_10_1007_s12672_024_00875_8 crossref_primary_10_3389_fcell_2022_853324 crossref_primary_10_1007_s11010_024_05175_x crossref_primary_10_1016_j_phymed_2022_154015 crossref_primary_10_1038_s41698_023_00482_w crossref_primary_10_1039_D4RA06253A crossref_primary_10_1186_s12885_023_10704_w crossref_primary_10_1016_j_saa_2024_124721 crossref_primary_10_1038_s41420_022_01240_w crossref_primary_10_1016_j_bioorg_2023_107078 crossref_primary_10_3390_ph16101466 crossref_primary_10_31612_2616_4868_3_2025_07 crossref_primary_10_1007_s10735_023_10178_x crossref_primary_10_3390_cancers16040796 crossref_primary_10_1126_scitranslmed_abl3649 crossref_primary_10_3389_fonc_2023_1325452 crossref_primary_10_1016_j_yexcr_2021_113006 crossref_primary_10_3389_fpsyg_2024_1479540 crossref_primary_10_1038_s41416_022_02012_0 crossref_primary_10_1080_07391102_2023_2247087 |
| Cites_doi | 10.1056/NEJMoa050434 10.1038/s41572-019-0111-2 10.1016/j.cell.2009.11.007 10.1186/s13244-020-00885-4 10.3389/fmed.2018.00248 10.1016/j.cell.2015.04.042 10.1158/2159-8290.CD-11-0101 10.1158/1078-0432.CCR-04-2469 10.1016/j.cell.2011.11.025 10.1101/gad.277681.116 10.1002/cncr.23189 10.1038/nrc1370 10.1002/jcp.1041500314 10.1158/1078-0432.CCR-18-3663 10.1038/s41392-020-0134-x 10.1007/s40265-019-01208-8 10.1016/j.ccr.2007.12.003 10.1371/journal.pmed.1002204 10.1002/cncr.23852 10.1016/B978-0-12-397927-8.00011-7 10.1158/0008-5472.CAN-18-0887 10.1016/j.molonc.2016.09.009 10.1016/j.gde.2010.10.011 10.1200/JCO.2007.15.0946 10.6004/jnccn.2020.0016 10.1097/PAI.0000000000000483 10.1146/annurev.med.49.1.111 10.1016/j.cell.2014.07.013 10.1038/nm0806-875 10.1016/j.ccell.2017.01.002 10.1002/ijc.26031 10.1038/s41586-019-0915-y 10.1111/j.1524-4741.2007.00506.x 10.1038/ng.3214 10.1038/s43018-020-0088-5 10.1093/annonc/mds248 10.6004/jnccn.2018.7281 10.1016/S0002-9440(10)65628-3 10.1038/nrc2621 10.1158/0008-5472.CAN-08-2590 10.1038/s41568-019-0199-4 10.1073/pnas.1016234107 10.1172/JCI42002 10.1038/255197a0 10.1038/nature20609 10.1038/nature11412 10.1200/JCO.2012.45.9859 10.1038/s41586-018-0040-3 10.4137/CGM.S31244 10.1007/s00330-014-3256-0 10.3390/cancers11081207 10.1093/jnci/85.17.1419 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2 10.1200/JCO.2008.17.0563 10.1097/MD.0000000000004874 10.1158/1078-0432.CCR-17-0369 10.1083/jcb.147.1.89 10.1126/science.aao4227 10.6004/jnccn.2018.7024 10.1093/jjco/hyz018 10.3322/CA.2008.0001 10.1158/2159-8290.CD-18-0264 10.1080/19336918.2015.1059563 10.1038/nature21104 10.1186/bcr2092 10.1007/s10585-015-9697-2 10.1200/JCO.2015.62.3504 10.1158/1078-0432.CCR-07-4082 10.5858/134.7.e48 10.1016/j.cell.2017.01.018 10.1126/science.1203543 10.1200/JCO.2007.14.2364 10.1038/nrc2256 10.1038/nrm3902 10.1038/427787a 10.3389/fonc.2018.00431 10.1056/NEJMoa040766 10.3322/caac.21590 10.1200/JOP.0768504 10.1126/scitranslmed.aad6352 10.1634/theoncologist.2014-0443 10.1016/j.pharmthera.2018.06.008 10.1007/s10147-014-0759-2 10.1038/nrc1075 10.1111/j.1349-7006.2009.01472.x 10.1038/bjc.2017.24 10.1007/s10549-005-5199-2 10.1038/nature20785 10.1002/cncr.25145 10.1158/0008-5472.CAN-16-3279 10.1186/s13058-014-0489-4 10.1016/j.pharmthera.2017.12.012 10.1136/esmoopen-2019-000565 10.1038/nrc2627 10.1038/nmeth.4640 10.1158/0008-5472.CAN-10-1040 10.1038/onc.2009.419 10.1016/j.cell.2011.09.024 10.1056/NEJMra0805239 10.1038/nature10694 10.3389/fendo.2019.00573 10.3389/fonc.2019.00498 10.1002/hep.24108 10.1073/pnas.84.23.8672 10.1038/35021093 10.1038/nm0295-149 10.1007/s10549-008-0023-4 10.1016/S0140-6736(05)66544-0 10.1371/journal.pbio.0040083 10.1001/jama.271.20.1587 10.1016/j.cell.2006.11.001 10.1016/j.ccr.2011.11.002 10.1016/j.ccell.2020.03.009 10.1016/j.clbc.2016.05.014 10.1007/s00404-016-4225-4 10.1074/jbc.M116.737379 10.1016/j.breast.2011.07.008 10.1016/j.coi.2014.01.004 10.1038/ncb2767 10.1038/s41576-018-0071-5 10.1126/science.aaf2784 10.1091/mbc.12.4.863 10.1093/jnci/91.1.80 10.1038/nrc.2017.6 10.1038/nrc3793 10.1016/j.ejca.2010.02.027 10.1158/1078-0432.CCR-04-1110 10.1016/j.yexmp.2020.104404 10.1002/1878-0261.12022 10.2147/OTT.S231493 10.1093/jncics/pky062 10.1101/gad.169029.111 10.1038/s41467-018-03215-x 10.1073/pnas.1106613108 10.1001/jamaoncol.2019.1838 10.1016/j.ebiom.2020.102793 10.1016/0092-8674(90)90186-I 10.1007/s12254-018-0450-9 10.1093/annonc/mdr304 10.1007/s11060-017-2717-0 10.1016/S0065-230X(08)60811-8 10.1200/JCO.2009.25.9820 10.1158/1078-0432.CCR-08-1135 10.1016/j.surg.2013.04.004 10.1038/nrc1098 10.1016/S0140-6736(16)31891-8 10.1126/science.aaf6546 10.1101/cshperspect.a006098 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2020 The Author(s) 2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2020 – notice: The Author(s) 2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7RV 7TO 7U9 7X7 7XB 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AN0 AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB0 LK8 M0S M1P M7P NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 5PM |
| DOI | 10.1038/s41416-020-01161-4 |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nursing & Allied Health Database Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland British Nursing Database ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Biological Science Database ProQuest Nursing and Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition British Nursing Index with Full Text ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | ProQuest Central Student MEDLINE - Academic CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1532-1827 |
| EndPage | 26 |
| ExternalDocumentID | PMC7782773 33239679 10_1038_s41416_020_01161_4 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Review Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: U.S. Department of Defense (United States Department of Defense) grantid: W81XWH1810616 funderid: https://doi.org/10.13039/100000005 – fundername: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) grantid: R01CA20425 funderid: https://doi.org/10.13039/100000054 – fundername: NCI NIH HHS grantid: R01 CA204253 – fundername: U.S. Department of Defense (United States Department of Defense) grantid: W81XWH1810616 – fundername: ; grantid: R01CA20425 – fundername: ; grantid: W81XWH1810616 |
| GroupedDBID | --- 0R~ 23N 36B 39C 4.4 406 53G 5GY 5RE 6J9 70F 7RV 7X7 88E 8AO 8C1 8FI 8FJ 8R4 8R5 AACDK AANZL AASML AATNV AAWTL AAYZH AAZLF ABAKF ABLJU ABOCM ABUWG ABZZP ACAOD ACGFO ACGFS ACKTT ACPRK ACRQY ACZOJ ADBBV ADFRT ADHDB AEFQL AEJRE AEMSY AENEX AEVLU AEXYK AFBBN AFKRA AFRAH AFSHS AGAYW AGHAI AGQEE AHMBA AHSBF AIGIU AILAN AJRNO ALFFA ALMA_UNASSIGNED_HOLDINGS AMYLF AN0 AOIJS ASPBG AVWKF AXYYD AZFZN BAWUL BBNVY BENPR BHPHI BKEYQ BKKNO BNQBC BPHCQ BVXVI C6C CCPQU CS3 DIK DNIVK DPUIP DU5 E3Z EAP EBLON EBS EE. EIOEI EMB ESX EX3 F5P FDQFY FEDTE FERAY FIGPU FRJ FSGXE FYUFA GX1 HCIFZ HMCUK HVGLF HYE HZ~ IH2 IWAJR JSO JZLTJ KQ8 M1P M7P NAPCQ NQJWS O9- OK1 P2P PQQKQ PROAC PSQYO Q2X RNT RNTTT ROL RPM SNX SNYQT SOHCF SOJ SRMVM SWTZT TAOOD TBHMF TDRGL TR2 UKHRP W2D WH7 WOW ~02 AAFWJ AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC AEZWR AFDZB AFFHD AFHIU AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT PJZUB PPXIY PQGLB -Q- .55 .GJ 3V. 8WZ A6W ABAWZ ABDBF ACUHS AI. B0M CAG CGR COF CUY CVF EAD EAS EBC EBD ECM EIF EJD EMK EMOBN EPL FIZPM J5H M41 NAO NPM SV3 TUS UDS VH1 X7M Y6R ZGI ~8M 7TO 7U9 7XB 8FE 8FH 8FK AZQEC DWQXO GNUQQ H94 K9. LK8 PKEHL PQEST PQUKI PRINS 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c540t-ddb932b9c4092d400238c353822435a68688d66294b0ce99efd067fca72da5c73 |
| IEDL.DBID | 7X7 |
| ISICitedReferencesCount | 438 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000592594000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0007-0920 1532-1827 |
| IngestDate | Tue Nov 04 01:53:21 EST 2025 Wed Oct 01 14:34:12 EDT 2025 Mon Oct 06 18:28:07 EDT 2025 Wed Feb 19 02:09:41 EST 2025 Tue Nov 18 22:15:24 EST 2025 Sat Nov 29 02:47:32 EST 2025 Fri Feb 21 02:38:13 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c540t-ddb932b9c4092d400238c353822435a68688d66294b0ce99efd067fca72da5c73 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0002-1412-1351 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC7782773 |
| PMID | 33239679 |
| PQID | 2474990342 |
| PQPubID | 41855 |
| PageCount | 14 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7782773 proquest_miscellaneous_2464605801 proquest_journals_2474990342 pubmed_primary_33239679 crossref_citationtrail_10_1038_s41416_020_01161_4 crossref_primary_10_1038_s41416_020_01161_4 springer_journals_10_1038_s41416_020_01161_4 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-01-05 |
| PublicationDateYYYYMMDD | 2021-01-05 |
| PublicationDate_xml | – month: 01 year: 2021 text: 2021-01-05 day: 05 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | British journal of cancer |
| PublicationTitleAbbrev | Br J Cancer |
| PublicationTitleAlternate | Br J Cancer |
| PublicationYear | 2021 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | DasguptaALimARGhajarCMCirculating and disseminated tumor cells: harbingers or initiators of metastasis?Mol. Oncol.2017114061280852235423226 RyuEBChangJMSeoMKimSALimJHMoonWKTumour volume doubling time of molecular breast cancer subtypes assessed by serial breast ultrasoundEur. Radiol.2014242227223524895040 McGranahanNSwantonCClonal heterogeneity and tumor evolution: past, present, and the futureCell20171686136281:CAS:528:DC%2BC2sXis1ygtLg%3D28187284 BardelliAPantelKLiquid biopsies, what we do not know (yet)Cancer Cell2017311721791:CAS:528:DC%2BC2sXis1ylt7Y%3D28196593 PerouCMSørlieTEisenMBvan de RijnMJeffreySSReesCAMolecular portraits of human breast tumoursNature20004067477521:CAS:528:DC%2BD3cXmt1CnsLw%3D10963602 Jahanban-Esfahlan, R., Seidi, K., Manjili, M. H., Jahanban-Esfahlan, A., Javaheri, T. & Zare, P. Tumor cell dormancy: threat or opportunity in the fight against cancer. Cancers11, 1207 (2019). KleinCAParallel progression of primary tumours and metastasesNat. Rev. Cancer200993023121:CAS:528:DC%2BD1MXjsFSrsr8%3D19308069 WeckermannDPolzerBRaggTBlanaASchlimokGArnholdtHPerioperative activation of disseminated tumor cells in bone marrow of patients with prostate cancerJ. Clin. Oncol.2009271549155619237635 RinnerthalerGGampenriederSPGreilRASCO 2018 highlights: metastatic breast cancerMemo201811276279305957536280779 CollerHASangLRobertsJMA new description of cellular quiescencePLoS Biol.20064e83165097721393757 ValastyanSWeinbergRATumor metastasis: molecular insights and evolving paradigmsCell20111472752921:CAS:528:DC%2BC3MXhtlaksb3N220000093261217 HeitzerEHaqueISRobertsCESSpeicherMRCurrent and future perspectives of liquid biopsies in genomics-driven oncologyNat. Rev. Genet.20192071881:CAS:528:DC%2BC1cXitFersbrF30410101 Rudzka, D. A., Spennati, G., McGarry, D. J., Chim, Y. H., Neilson, M., Ptak, A. et al. Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization. J. Cell Sci.132, jcs224071 (2019). Weinstat-SaslowDLZabrenetzkyVSVanHoutteKFrazierWARobertsDDSteegPSTransfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesisCancer Res.199454650465111:CAS:528:DyaK2MXislalsLo%3D7527299 BarkanDGreenJEChambersAFExtracellular matrix: a gatekeeper in the transition from dormancy to metastatic growthEur. J. Cancer201046118111881:CAS:528:DC%2BC3cXkvFKqtr4%3D203046302856784 SottorivaAKangHMaZGrahamTASalomonMPZhaoJA Big Bang model of human colorectal tumor growthNat. Genet.2015472092161:CAS:528:DC%2BC2MXhvFCntbo%3D256650064575589 MlecnikBBindeaGKirilovskyAAngellHKObenaufACTosoliniMThe tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasisSci. Transl. Med.20168327ra2626912905 GreeneFLSobinLHThe staging of cancer: a retrospective and prospective appraisalCA Cancer J. Clin.20085818019018460593 YangZLiNLiXLeiLWangXThe prognostic impact of hormonal receptor and HER-2 expression discordance in metastatic breast cancer patientsOncoTargets Ther.2020138538631:CAS:528:DC%2BB3cXhtlGit7%2FN VieiraAFSchmittFAn update on breast cancer multigene prognostic tests-emergent clinical biomarkersFront. Med.20185248 DenoixPFNomenclature and classification of cancers based on an atlasActa Unio Int. Contra Cancrum195397697711:STN:280:DyaG2c%2FlvVagsg%3D%3D13138342 VenetDFimereliDRotheFBoeckxBMaetensMMajjajSPhylogenetic reconstruction of breast cancer reveals two routes of metastatic dissemination associated with distinct clinical outcomeeBioMedicine202056102793325125087281848 BraunSVoglFDNaumeBJanniWOsborneMPCoombesRCA pooled analysis of bone marrow micrometastasis in breast cancerN. Engl. J. Med.20053537938021:CAS:528:DC%2BD2MXovVKlu7s%3D16120859 Early Breast Cancer Trialists' Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet365, 1687–1717 (2005). O’LearyBCuttsRJLiuYHrebienSHuangXFenwickKThe genetic landscape and clonal evolution of breast cancer resistance to palbociclib plus fulvestrant in the PALOMA-3 trialCancer Discov.2018813901403302061106368247 WeissLMetastatic inefficiencyAdv. Cancer Res.1990541592111:STN:280:DyaK3c7hvFSisw%3D%3D1688681 SchlimokGFunkeIHolzmannBGottlingerGSchmidtGHauserHMicrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1A monoclonal antibodiesProc. Natl Acad. Sci. USA198784867286761:STN:280:DyaL1c%2FmvVKmsw%3D%3D2446326299608 CheungKJEwaldAJA collective route to metastasis: seeding by tumor cell clustersScience20163521671691:CAS:528:DC%2BC28XlsFSmtb8%3D271244498183671 CairnsJMutation selection and the natural history of cancerNature19752551972001:CAS:528:DyaE2MXkvFCmsb0%3D1143315 HosseiniHObradovićMMSHoffmannMHarperKLSosaMSWerner-KleinMEarly dissemination seeds metastasis in breast cancerNature20165405525581:CAS:528:DC%2BC28XitFWntr%2FN279747995390864 Celià-TerrassaTKangYDistinctive properties of metastasis-initiating cellsGenes Dev.201630892908270839974840296 SchraderJGordon-WalkerTTAucottRLvan DeemterMQuaasAWalshSMatrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cellsHepatology201153119212051:CAS:528:DC%2BC3MXktl2ju74%3D21442631 NortonLMassaguéJIs cancer a disease of self-seeding?Nat. Med.2006128758781:CAS:528:DC%2BD28Xnsl2itLk%3D16892025 ThieryJPAcloqueHHuangRYNietoMAEpithelial-mesenchymal transitions in development and diseaseCell20091398718901:CAS:528:DC%2BC3cXksFWltA%3D%3D19945376 FehmTKrawczykNSolomayerEFBecker-PergolaGDürr-StörzerSNeubauerHERalpha-status of disseminated tumour cells in bone marrow of primary breast cancer patientsBreast Cancer Res.200810187933872614509 Impact of follow-up testing on survival and health-related quality of life in breast cancer patients. A multicenter randomized controlled trial. The GIVIO Investigators. J. Am. Med. Assoc.271, 1587–1592 (1994). LinNUWinerEPAdvances in adjuvant endocrine therapy for postmenopausal womenJ. Clin. Oncol.2008267988051:CAS:528:DC%2BD1cXivF2isbc%3D18258989 HongSPChanTELombardoYCorleoneGRotmenszNBravacciniSSingle-cell transcriptomics reveals multi-step adaptations to endocrine therapyNat. Commun.201910314776986718416 HumtsoeJOKramerRHDifferential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathwayOncogene201029121412261:CAS:528:DC%2BD1MXhsVGlurvI19935697 MüllerVStahmannNRiethdorfSRauTZabelTGoetzACirculating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activityClin. Cancer Res.2005113678368515897564 FribergSMattsonSOn the growth rates of human malignant tumors: implications for medical decision makingJ. Surg. Oncol.1997652842971:STN:280:DyaK2svhvVOiuw%3D%3D9274795 OltraASantaballaAMunárrizBPastorMMontalarJCost-benefit analysis of a follow-up program in patients with breast cancer: a randomized prospective studyBreast J.20071357157417983398 GradisharWJAndersonBOAbrahamJAftRAgneseDAllisonKHBreast cancer, version 3.2020, NCCN clinical practice guidelines in oncologyJ. Natl Compr. Canc Netw.2020184524781:CAS:528:DC%2BB3cXitV2js7bO32259783 PantelKSchlimokGBraunSKutterDLindemannFSchallerGDifferential expression of proliferation-associated molecules in individual micrometastatic carcinoma cellsJ. Natl Cancer Inst.199385141914241:STN:280:DyaK3szltlGntw%3D%3D7688814 American Cancer Society. Cancer Facts & Figures 2019 (American Cancer Society, Atlanta, 2019). GeorgescuRBorosMMonceaDBauerOCorosMFOpreaADiscordance rate in estrogen receptor, progesterone receptor, HER2 Status, and Ki67 index between primary unifocal and multiple homogenous breast carcinomas and synchronous axillary lymph node metastases have an impact on therapeutic decisionAppl. Immunohistochem. Mol. Morphol.2018265335381:CAS:528:DC%2BC1cXhs1OntLfL28099174 KoopSMacDonaldICLuzziKSchmidtEEMorrisVLGrattanMFate of melanoma cells entering the microcirculation: over 80% survive and extravasateCancer Res.199555252025231:CAS:528:DyaK2MXmtlWrsb4%3D7780961 HarbeckNPenault-LlorcaFCortesJGnantMHoussamiNPoortmansPBreast cancerNat. Rev. Dis. Prim.201956631548545 HarperKLSosaMSEntenbergDHosseiniHCheungJFNobreRMechanism of early dissemination and metastasis in Her2(+) mammary cancerNature20165405885921:CAS:528:DC%2BC28XitFWntr7L279747985471138 JinXMuPTargeting breast cancer metastasisBreast Cancer201592334263805524559199 FribergSNyströmACancer metastases: early dissemination and late recurrencesCancer Growth Metastasis201584349266403894664198 HüsemannYGeiglJBSchubertFMusianiPMeyerMBurghartESystemic spread is an early step in breast cancerCancer Cell200813586818167340 CameronMDSchmidtEEKerkvlietNNadkarniKVMorrisVLGroomACTemporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiencyCancer Res.200060254125461:CAS:528:DC%2BD3cXjtV2qtb4%3D10811137 HarrisLFritscheHMennelRNortonLRavdinPTaubeSAmerican Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancerJ. Clin. Oncol.200725528753121:CAS:528:DC%2BD2sXhsVKnsbzK17954709 Aguirre-GhisoJAModels, mechanisms and clinical evidence for cancer dormancyNat. Rev. Cancer200778348461:CAS:528:DC%2BD2sXht1Wgsb%2FO179571892519109 DawoodSBroglioKValeroVReubenJHandyBIslamRCirculating tumor cells in metastatic breast cancer: from prognostic stratification to modification of the staging system?Cancer20081132422243018785255 LuXMuEWeiYRiethdorfSYangQYuanMVCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitorsCancer Cell2011207017141:CAS:528:DC%2BC3MXhs1Cit77P221377943241854 LynceFShajahan-HaqANSwainSMCDK4/6 inhibitors in breast cancer therapy: current practice and future opportunitiesPharm. Ther.201819165731:CAS:528:DC%2BC1cXhtFynu7vN Iacobuzio-DonahueCAMicha V Müller (1161_CR108) 2005; 11 AS Azevedo (1161_CR77) 2015; 9 HF Wang (1161_CR99) 2019; 9 B O’Leary (1161_CR167) 2018; 8 C Bartmann (1161_CR116) 2017; 295 JP Thiery (1161_CR73) 2009; 139 D Weckermann (1161_CR105) 2009; 27 1161_CR10 X Lu (1161_CR93) 2011; 20 M Colleoni (1161_CR25) 2016; 34 AB Hanker (1161_CR120) 2020; 37 BL Franc (1161_CR152) 2018; 16 EB Ryu (1161_CR115) 2014; 24 N McGranahan (1161_CR79) 2017; 168 S Koop (1161_CR78) 1995; 55 Z Yang (1161_CR139) 2020; 13 1161_CR1 MM Haque (1161_CR125) 2019; 10 1161_CR100 T Celià-Terrassa (1161_CR81) 2016; 30 S Seltzer (1161_CR7) 2020; 114 AD Rhim (1161_CR48) 2012; 148 1161_CR92 B Mlecnik (1161_CR71) 2016; 8 BM Szczerba (1161_CR60) 2019; 566 AF Vieira (1161_CR31) 2018; 5 J Jung (1161_CR136) 2018; 137 JM Wu (1161_CR146) 2008; 14 JA Aguirre-Ghiso (1161_CR94) 2007; 7 DL Weinstat-Saslow (1161_CR102) 1994; 54 K Pantel (1161_CR106) 1993; 85 S Sharma (1161_CR85) 2016; 291 WL Lu (1161_CR158) 2009; 114 B Psaila (1161_CR68) 2009; 9 SH Lee (1161_CR114) 2016; 95 S Park (1161_CR27) 2012; 21 S Shiino (1161_CR142) 2016; 16 H Weedon-Fekjaer (1161_CR113) 2008; 10 B O’Leary (1161_CR168) 2018; 9 S Paget (1161_CR64) 1989; 8 N Harbeck (1161_CR117) 2019; 5 A Zomer (1161_CR69) 2015; 161 HA Coller (1161_CR84) 2006; 4 J Cairns (1161_CR41) 1975; 255 S Yuda (1161_CR140) 2019; 49 WJ Gradishar (1161_CR149) 2020; 18 A Sottoriva (1161_CR147) 2015; 47 RR Gomis (1161_CR23) 2017; 11 Y Hüsemann (1161_CR47) 2008; 13 A Awada (1161_CR126) 2019; 4 A Dasgupta (1161_CR58) 2017; 11 MG Best (1161_CR162) 2018; 78 S Braun (1161_CR110) 2005; 353 C Hirsch-Ginsberg (1161_CR166) 1998; 49 KL Harper (1161_CR45) 2016; 540 S Friberg (1161_CR51) 2015; 8 S Dawood (1161_CR112) 2008; 113 IJ Fidler (1161_CR12) 2003; 3 MV Dieci (1161_CR134) 2013; 24 F Pesapane (1161_CR159) 2020; 11 MS Sosa (1161_CR17) 2014; 14 V Aggelis (1161_CR118) 2019; 79 KI Pritchard (1161_CR124) 2008; 112 CM Ghajar (1161_CR52) 2016; 540 JA Aguirre Ghiso (1161_CR86) 1999; 147 X Jin (1161_CR13) 2015; 9 CA Iacobuzio-Donahue (1161_CR144) 2019; 19 D Mittal (1161_CR98) 2014; 27 K Pantel (1161_CR3) 2004; 4 1161_CR9 1161_CR20 S Krishnamurthy (1161_CR50) 2010; 116 J Schrader (1161_CR91) 2011; 53 R Georgescu (1161_CR135) 2018; 26 JA Aguirre-Ghiso (1161_CR89) 2003; 63 KJ Cheung (1161_CR54) 2016; 352 S Friberg (1161_CR43) 1997; 65 FL Greene (1161_CR30) 2008; 58 RL Siegel (1161_CR2) 2020; 70 R Somasundaram (1161_CR80) 2012; 65 T Fehm (1161_CR103) 2008; 10 N Ogba (1161_CR122) 2014; 16 F Lynce (1161_CR130) 2018; 191 GP Gupta (1161_CR6) 2006; 127 P Savas (1161_CR37) 2016; 13 H Hosseini (1161_CR46) 2016; 540 H Kennecke (1161_CR28) 2010; 28 CM Ghajar (1161_CR101) 2013; 15 RC Coombes (1161_CR164) 2019; 25 L Gerratana (1161_CR14) 2015; 32 S Valastyan (1161_CR4) 2011; 147 L Holmgren (1161_CR96) 1995; 1 R Demicheli (1161_CR26) 2010; 101 N Harbeck (1161_CR32) 2017; 389 I Garcia-Murillas (1161_CR165) 2019; 5 JL Caswell-Jin (1161_CR8) 2018; 2 R Wang (1161_CR15) 2019; 19 PF Denoix (1161_CR29) 1953; 9 EW Thompson (1161_CR143) 1992; 150 L Harris (1161_CR19) 2007; 25 RC Miles (1161_CR153) 2019; 17 JA Aguirre-Ghiso (1161_CR90) 2001; 12 D Venet (1161_CR39) 2020; 56 JO Humtsoe (1161_CR88) 2010; 29 J Fares (1161_CR18) 2020; 5 G Schlimok (1161_CR104) 1987; 84 NU Lin (1161_CR119) 2008; 26 PS Steeg (1161_CR145) 2008; 14 A Goldhirsch (1161_CR22) 2011; 22 1161_CR49 SP Hong (1161_CR121) 2019; 10 TW Miller (1161_CR129) 2011; 1 S De Placido (1161_CR151) 2017; 116 1161_CR128 JE Talmadge (1161_CR34) 2010; 70 JW Uhr (1161_CR16) 2011; 108 CA Klein (1161_CR33) 2009; 9 D Barkan (1161_CR87) 2010; 46 1161_CR133 1161_CR132 VP Collins (1161_CR42) 1956; 76 CA Klein (1161_CR83) 2011; 21 H Peinado (1161_CR67) 2017; 17 DG Duda (1161_CR59) 2010; 107 AD Wong (1161_CR57) 2017; 77 US Asghar (1161_CR131) 2017; 23 HK Patel (1161_CR123) 2018; 186 1161_CR75 1161_CR157 N Almog (1161_CR97) 2009; 69 J Folkman (1161_CR95) 2004; 427 S Meng (1161_CR107) 2004; 10 M Cristofanilli (1161_CR111) 2004; 351 V Marx (1161_CR82) 2018; 15 JL Khatcheressian (1161_CR150) 2013; 31 TG Karrison (1161_CR24) 1999; 91 CG Murphy (1161_CR127) 2015; 20 AD Parmar (1161_CR154) 2013; 154 1161_CR72 I Pastushenko (1161_CR56) 2018; 556 J Eyles (1161_CR44) 2010; 120 I Malanchi (1161_CR109) 2011; 481 SL Shiao (1161_CR70) 2011; 25 GA Stanley (1161_CR38) 2012; 3 JK Mouw (1161_CR53) 2014; 15 P Friedl (1161_CR55) 2003; 3 N Aceto (1161_CR61) 2014; 158 A Matsumoto (1161_CR137) 2015; 20 R Kokko (1161_CR155) 2005; 93 1161_CR148 AC Chiang (1161_CR11) 2008; 359 L Weiss (1161_CR76) 1990; 54 MD Cameron (1161_CR66) 2000; 60 ER Fearon (1161_CR40) 1990; 61 ME Hammond (1161_CR141) 2010; 134 G Rinnerthaler (1161_CR160) 2018; 11 A Bardelli (1161_CR161) 2017; 31 CL Chaffer (1161_CR5) 2011; 331 1161_CR62 KJ Luzzi (1161_CR63) 1998; 153 L Norton (1161_CR36) 2006; 12 RR Langley (1161_CR65) 2011; 128 S Turajlic (1161_CR35) 2016; 352 V Poltavets (1161_CR74) 2018; 8 E Heitzer (1161_CR163) 2019; 20 CM Perou (1161_CR21) 2000; 406 M Timmer (1161_CR138) 2017; 37 A Oltra (1161_CR156) 2007; 13 36316559 - Br J Cancer. 2023 Feb;128(3):484-485 |
| References_xml | – reference: DawoodSBroglioKValeroVReubenJHandyBIslamRCirculating tumor cells in metastatic breast cancer: from prognostic stratification to modification of the staging system?Cancer20081132422243018785255 – reference: Rudzka, D. A., Spennati, G., McGarry, D. J., Chim, Y. H., Neilson, M., Ptak, A. et al. Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization. J. Cell Sci.132, jcs224071 (2019). – reference: JungJLeeSHParkMYounJHShinSHGwakHSDiscordances in ER, PR, and HER2 between primary breast cancer and brain metastasisJ. Neurooncol.20181372953021:CAS:528:DC%2BC1cXhs1Wmsw%3D%3D29260362 – reference: GhajarCMPeinadoHMoriHMateiIREvasonKJBrazierHThe perivascular niche regulates breast tumour dormancyNat. Cell Biol.2013158078171:CAS:528:DC%2BC3sXosFais7c%3D237284253826912 – reference: HumtsoeJOKramerRHDifferential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathwayOncogene201029121412261:CAS:528:DC%2BD1MXhsVGlurvI19935697 – reference: TalmadgeJEFidlerIJAACR centennial series: the biology of cancer metastasis: historical perspectiveCancer Res.201070564956691:CAS:528:DC%2BC3cXovVantLY%3D206106254037932 – reference: ValastyanSWeinbergRATumor metastasis: molecular insights and evolving paradigmsCell20111472752921:CAS:528:DC%2BC3MXhtlaksb3N220000093261217 – reference: MalanchiISantamaria-MartínezASusantoEPengHLehrHADelaloyeJFInteractions between cancer stem cells and their niche govern metastatic colonizationNature2011481858922158103 – reference: AzevedoASFollainGPatthabhiramanSHarleppSGoetzJGMetastasis of circulating tumor cells: favorable soil or suitable biomechanics, or both?Cell Adh Migr.201593453561:CAS:528:DC%2BC28XhslOjsr0%3D263126534955369 – reference: YudaSShimizuCYoshidaMShiinoSKinoshitaTMaeshimaAMBiomarker discordance between primary breast cancer and bone or bone marrow metastasesJpn. J. Clin. Oncol.20194942643030793198 – reference: Risson, E., Nobre, A. R., Maguer-Satta, V. & Aguirre-Ghiso, J. A. The current paradigm and challenges ahead for the dormancy of disseminated tumor cells. Nat. Cancerhttps://doi.org/10.1038/s43018-020-0088-5 (2020). – reference: PerouCMSørlieTEisenMBvan de RijnMJeffreySSReesCAMolecular portraits of human breast tumoursNature20004067477521:CAS:528:DC%2BD3cXmt1CnsLw%3D10963602 – reference: LuWLJansenLPostWJBonnemaJVan de VeldeJCDe BockGHImpact on survival of early detection of isolated breast recurrences after the primary treatment for breast cancer: a meta-analysisBreast Cancer Res. Treat.20091144034121:STN:280:DC%2BD1M7mslKmuw%3D%3D18421576 – reference: CameronMDSchmidtEEKerkvlietNNadkarniKVMorrisVLGroomACTemporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiencyCancer Res.200060254125461:CAS:528:DC%2BD3cXjtV2qtb4%3D10811137 – reference: KleinCAFramework models of tumor dormancy from patient-derived observationsCurr. Opin. Genet. Dev.20112142491:CAS:528:DC%2BC3MXhvFKjtbs%3D21145726 – reference: YangZLiNLiXLeiLWangXThe prognostic impact of hormonal receptor and HER-2 expression discordance in metastatic breast cancer patientsOncoTargets Ther.2020138538631:CAS:528:DC%2BB3cXhtlGit7%2FN – reference: MurphyCGDicklerMNThe Role of CDK4/6 Inhibition in Breast CancerOncologist2015204834901:CAS:528:DC%2BC2MXhtFCntbvI258769934425391 – reference: Sänger, N., Effenberger, K. E., Riethdorf, S., Van Haasteren, V., Gauwerky, J., Wiegratz, I. et al. Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ. Int. J. Cancer129, 2522–2526 (2011). – reference: ParkSKooJSKimMSParkHSLeeJSLeeJSCharacteristics and outcomes according to molecular subtypes of breast cancer as classified by a panel of four biomarkers using immunohistochemistryBreast201221505721865043 – reference: ShiinoSKinoshitaTYoshidaMJimboKAsagaSTakayamaSPrognostic impact of discordance in hormone receptor status between primary and recurrent sites in patients with recurrent breast cancerClin. Breast Cancer201616e133e1401:CAS:528:DC%2BC28XptFyjsr4%3D27268749 – reference: LinNUWinerEPAdvances in adjuvant endocrine therapy for postmenopausal womenJ. Clin. Oncol.2008267988051:CAS:528:DC%2BD1cXivF2isbc%3D18258989 – reference: VieiraAFSchmittFAn update on breast cancer multigene prognostic tests-emergent clinical biomarkersFront. Med.20185248 – reference: FriedlPWolfKTumour-cell invasion and migration: diversity and escape mechanismsNat. Rev. Cancer200333623741:CAS:528:DC%2BD3sXjtlals7o%3D12724734 – reference: Aguirre-GhisoJALiuDMignattiAKovalskiKOssowskiLUrokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivoMol. Biol. Cell2001128638791:CAS:528:DC%2BD3MXjtVaqsL0%3D1129489232272 – reference: PritchardKICombining endocrine agents with chemotherapy: which patients and what sequence?Cancer20081127187221:CAS:528:DC%2BD1cXis1Wjsbk%3D18072257 – reference: HammondMEHayesDFDowsettMAllredDCHagertyKLBadveSAmerican Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version)Arch. Pathol. Lab. Med.2010134e48e721:CAS:528:DC%2BC3cXpsFShu7k%3D20586616 – reference: KhatcheressianJLHurleyPBantugEEssermanLJGrunfeldEHalbergFBreast cancer follow-up and management after primary treatment: American Society of Clinical Oncology clinical practice guideline updateJ. Clin. Oncol.2013319619651:CAS:528:DC%2BC3sXltVagtbY%3D23129741 – reference: PoltavetsVKochetkovaMPitsonSMSamuelMSThe role of the extracellular matrix and its molecular and cellular regulators in cancer cell plasticityFront. Oncol.20188431303566786189298 – reference: GreeneFLSobinLHThe staging of cancer: a retrospective and prospective appraisalCA Cancer J. Clin.20085818019018460593 – reference: WuJMFacklerMJHalushkaMKMolaviDWTaylorMETeoWWHeterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastasesClin. Cancer Res.200814193819461:CAS:528:DC%2BD1cXkt1aktbg%3D183819312965068 – reference: JinXMuPTargeting breast cancer metastasisBreast Cancer201592334263805524559199 – reference: HarperKLSosaMSEntenbergDHosseiniHCheungJFNobreRMechanism of early dissemination and metastasis in Her2(+) mammary cancerNature20165405885921:CAS:528:DC%2BC28XitFWntr7L279747985471138 – reference: OgbaNManningNGBliesnerBSAmblerSKHaughianJMPintoMPLuminal breast cancer metastases and tumor arousal from dormancy are promoted by direct actions of estradiol and progesterone on the malignant cellsBreast Cancer Res.201416254758974303198 – reference: ColleoniMSunZPriceKNKarlssonPForbesJFThurlimannBAnnual hazard rates of recurrence for breast cancer during 24 years of follow-up: results from the international breast cancer study group trials I to VJ. Clin. Oncol.2016349279351:CAS:528:DC%2BC2sXnvFOhtw%3D%3D267869334933127 – reference: LuXMuEWeiYRiethdorfSYangQYuanMVCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitorsCancer Cell2011207017141:CAS:528:DC%2BC3MXhs1Cit77P221377943241854 – reference: HeitzerEHaqueISRobertsCESSpeicherMRCurrent and future perspectives of liquid biopsies in genomics-driven oncologyNat. Rev. Genet.20192071881:CAS:528:DC%2BC1cXitFersbrF30410101 – reference: MlecnikBBindeaGKirilovskyAAngellHKObenaufACTosoliniMThe tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasisSci. Transl. Med.20168327ra2626912905 – reference: American Cancer Society. Cancer Facts & Figures 2019 (American Cancer Society, Atlanta, 2019). – reference: BarkanDGreenJEChambersAFExtracellular matrix: a gatekeeper in the transition from dormancy to metastatic growthEur. J. Cancer201046118111881:CAS:528:DC%2BC3cXkvFKqtr4%3D203046302856784 – reference: BartmannCWischnewskyMStüberTSteinRKrockenbergerMHäuslerSPattern of metastatic spread and subcategories of breast cancerArch. Gynecol. Obstet.201729521122327832352 – reference: SzczerbaBMCastro-GinerFVetterMKrolIGkountelaSLandinJNeutrophils escort circulating tumour cells to enable cell cycle progressionNature20195665535571:CAS:528:DC%2BC1MXmt1ygu7o%3D30728496 – reference: WangHFWangSSHuangMCLiangXHTangYJTangYLTargeting immune-mediated dormancy: a promising treatment of cancerFront. Oncol.201994981:CAS:528:DC%2BC1MXhsVShtQ%3D%3D312973356607988 – reference: FrancBLCopelandTPThombleyRParkMMarafinoBDeanMLGeographic variation in postoperative imaging for low-risk breast cancerJ. Natl Compr. Canc Netw.20181682983730006425 – reference: Hirsch-GinsbergCDetection of minimal residual disease: relevance for diagnosis and treatment of human malignanciesAnnu. Rev. Med.1998491111221:CAS:528:DyaK1cXhtFKru78%3D9509253 – reference: FehmTKrawczykNSolomayerEFBecker-PergolaGDürr-StörzerSNeubauerHERalpha-status of disseminated tumour cells in bone marrow of primary breast cancer patientsBreast Cancer Res.200810187933872614509 – reference: Garcia-MurillasIChopraNComino-MéndezIBeaneyMToveyHCuttsRJAssessment of molecular relapse detection in early-stage breast cancerJAMA Oncol.2019514731478313690456681568 – reference: PagetSThe distribution of secondary growths in cancer of the breastCancer Metastasis Rev.19898981011:STN:280:DyaL1Mzns1OmsA%3D%3D2673568 – reference: ZomerAMaynardCVerweijFJKamermansASchäferRBeerlingEIn Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behaviorCell2015161104610571:CAS:528:DC%2BC2MXpt1Sgt70%3D260004814448148 – reference: AlmogNMaLRaychowdhuryRSchwagerCErberRShortSTranscriptional switch of dormant tumors to fast-growing angiogenic phenotypeCancer Res.2009698368441:CAS:528:DC%2BD1MXhtFOktrc%3D19176381 – reference: UhrJWPantelKControversies in clinical cancer dormancyProc. Natl Acad. Sci. USA201110812396124001:CAS:528:DC%2BC3MXpvV2ls7Y%3D217468943145712 – reference: FribergSNyströmACancer metastases: early dissemination and late recurrencesCancer Growth Metastasis201584349266403894664198 – reference: RyuEBChangJMSeoMKimSALimJHMoonWKTumour volume doubling time of molecular breast cancer subtypes assessed by serial breast ultrasoundEur. Radiol.2014242227223524895040 – reference: KarrisonTGFergusonDJMeierPDormancy of mammary carcinoma after mastectomyJ. Natl Cancer Inst.19999180851:STN:280:DyaK1M7gsFWrsg%3D%3D9890174 – reference: Sever, R. & Brugge, J. S. Signal transduction in cancer. Cold Spring Harb. Perspect. Med.5, a006098 (2015). – reference: Aguirre-GhisoJAModels, mechanisms and clinical evidence for cancer dormancyNat. Rev. Cancer200778348461:CAS:528:DC%2BD2sXht1Wgsb%2FO179571892519109 – reference: ParmarADSheffieldKMVargasGMHanYChaoCRiallTSQuality of post-treatment surveillance of early stage breast cancer in TexasSurgery201315421422523889950 – reference: Jahanban-Esfahlan, R., Seidi, K., Manjili, M. H., Jahanban-Esfahlan, A., Javaheri, T. & Zare, P. Tumor cell dormancy: threat or opportunity in the fight against cancer. Cancers11, 1207 (2019). – reference: MittalDGubinMMSchreiberRDSmythMJNew insights into cancer immunoediting and its three component phases-elimination, equilibrium and escapeCurr. Opin. Immunol.20142716251:CAS:528:DC%2BC2cXmtVWktL4%3D245312414388310 – reference: GoldhirschAWoodWCCoatesASGelberRDThürlimannBSennHJStrategies for subtypes-dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011Ann. Oncol.201122173617471:STN:280:DC%2BC3Mjhs1ygug%3D%3D217091403144634 – reference: PsailaBLydenDThe metastatic niche: adapting the foreign soilNat. Rev. Cancer200992852931:CAS:528:DC%2BD1MXjsFSrtrk%3D193080683682494 – reference: SomasundaramRVillanuevaJHerlynMIntratumoral heterogeneity as a therapy resistance mechanism: role of melanoma subpopulationsAdv. Pharm.2012653353591:CAS:528:DC%2BC38XhvVCmtLrJ – reference: Caswell-JinJLPlevritisSKTianLCadhamCJXuCStoutNKChange in survival in metastatic breast cancer with treatment advances: meta-analysis and systematic reviewJNCI Cancer Spectr.20182pky062306276946305243 – reference: CoombesRCPageKSalariRHastingsRKArmstrongAAhmedSPersonalized detection of circulating tumor DNA antedates breast cancer metastatic recurrenceClin. Cancer Res.201925425542631:CAS:528:DC%2BB3cXhs1SmsbbN30992300 – reference: Weinstat-SaslowDLZabrenetzkyVSVanHoutteKFrazierWARobertsDDSteegPSTransfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesisCancer Res.199454650465111:CAS:528:DyaK2MXislalsLo%3D7527299 – reference: AcetoNBardiaAMiyamotoDTDonaldsonMCWittnerBSSpencerJACirculating tumor cell clusters are oligoclonal precursors of breast cancer metastasisCell2014158111011221:CAS:528:DC%2BC2cXhsV2jtLbL251714114149753 – reference: GomisRRGawrzakSTumor cell dormancyMol. Oncol.2017116278280172845423221 – reference: OltraASantaballaAMunárrizBPastorMMontalarJCost-benefit analysis of a follow-up program in patients with breast cancer: a randomized prospective studyBreast J.20071357157417983398 – reference: VenetDFimereliDRotheFBoeckxBMaetensMMajjajSPhylogenetic reconstruction of breast cancer reveals two routes of metastatic dissemination associated with distinct clinical outcomeeBioMedicine202056102793325125087281848 – reference: CollerHASangLRobertsJMA new description of cellular quiescencePLoS Biol.20064e83165097721393757 – reference: RhimADMirekETAielloNMMaitraABaileyJMMcAllisterFEMT and dissemination precede pancreatic tumor formationCell20121483493611:CAS:528:DC%2BC38XhtFKgtr8%3D222654203266542 – reference: ShiaoSLGanesanAPRugoHSCoussensLMImmune microenvironments in solid tumors: new targets for therapyGenes Dev.201125255925721:CAS:528:DC%2BC38Xlsl2ntA%3D%3D221904573248678 – reference: LynceFShajahan-HaqANSwainSMCDK4/6 inhibitors in breast cancer therapy: current practice and future opportunitiesPharm. Ther.201819165731:CAS:528:DC%2BC1cXhtFynu7vN – reference: FidlerIJThe pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisitedNat. Rev. Cancer200334534581:CAS:528:DC%2BD3sXktFOnsbg%3D12778135 – reference: AggelisVJohnstonSRDAdvances in endocrine-based therapies for estrogen receptor-positive metastatic breast cancerDrugs201979184918661:CAS:528:DC%2BC1MXhvF2gt77P31630379 – reference: SharmaSXingFLiuYWuKSaidNPochampallyRSecreted protein acidic and rich in cysteine (SPARC) mediates metastatic dormancy of prostate cancer in boneJ. Biol. Chem.201629119351193631:CAS:528:DC%2BC28XhsV2ju73I274228175016675 – reference: ChafferCLWeinbergRAA perspective on cancer cell metastasisScience2011331155915641:CAS:528:DC%2BC3MXjs1Cgtbo%3D21436443 – reference: EylesJPuauxALWangXTohBPrakashCHongMTumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanomaJ. Clin. Investig.2010120203020391:CAS:528:DC%2BC3cXnt1KqtLY%3D205019442877955 – reference: KoopSMacDonaldICLuzziKSchmidtEEMorrisVLGrattanMFate of melanoma cells entering the microcirculation: over 80% survive and extravasateCancer Res.199555252025231:CAS:528:DyaK2MXmtlWrsb4%3D7780961 – reference: SteegPSHeterogeneity of drug target expression among metastatic lesions: lessons from a breast cancer autopsy programClin. Cancer Res.20081436433645185595752692037 – reference: HarbeckNGnantMBreast cancerLancet20173891134115027865536 – reference: CheungKJEwaldAJA collective route to metastasis: seeding by tumor cell clustersScience20163521671691:CAS:528:DC%2BC28XlsFSmtb8%3D271244498183671 – reference: AsgharUSBarrARCuttsRBeaneyMBabinaISampathDSingle-cell dynamics determines response to CDK4/6 inhibition in triple-negative breast cancerClin. Cancer Res.201723556155721:CAS:528:DC%2BC2sXhsV2mu7nJ286069206175044 – reference: DasguptaALimARGhajarCMCirculating and disseminated tumor cells: harbingers or initiators of metastasis?Mol. Oncol.2017114061280852235423226 – reference: LuzziKJMacDonaldICSchmidtEEKerkvlietNMorrisVLChambersAFMultistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastasesAm. J. Pathol.19981538658731:STN:280:DyaK1cvgsFCnsA%3D%3D97360351853000 – reference: SchraderJGordon-WalkerTTAucottRLvan DeemterMQuaasAWalshSMatrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cellsHepatology201153119212051:CAS:528:DC%2BC3MXktl2ju74%3D21442631 – reference: MengSTripathyDFrenkelEPSheteSNaftalisEZHuthJFCirculating tumor cells in patients with breast cancer dormancyClin. Cancer Res.2004108152816215623589 – reference: MatsumotoAJinnoHMurataTSekiTTakahashiMHayashidaTPrognostic implications of receptor discordance between primary and recurrent breast cancerInt. J. Clin. Oncol.2015207017081:CAS:528:DC%2BC2cXhvVyqsrvM25348193 – reference: PeinadoHZhangHMateiIRCosta-SilvaBHoshinoARodriguesGPre-metastatic niches: organ-specific homes for metastasesNat. Rev. Cancer2017173023171:CAS:528:DC%2BC2sXkt1Ont7w%3D28303905 – reference: ThompsonEWPaikSBrünnerNSommersCLZugmaierGClarkeRAssociation of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell linesJ. Cell Physiol.19921505345441:CAS:528:DyaK38XhslWhur4%3D1537883 – reference: BardelliAPantelKLiquid biopsies, what we do not know (yet)Cancer Cell2017311721791:CAS:528:DC%2BC2sXis1ylt7Y%3D28196593 – reference: StanleyGABalaniJPMillerDSMansourJCSchwarzREClinical evidence: metastases can metastasizeWorld J. Oncol.20123138141291472965649794 – reference: NortonLMassaguéJIs cancer a disease of self-seeding?Nat. Med.2006128758781:CAS:528:DC%2BD28Xnsl2itLk%3D16892025 – reference: PantelKBrakenhoffRHDissecting the metastatic cascadeNat. Rev. Cancer200444484561:CAS:528:DC%2BD2cXksVaisbY%3D15170447 – reference: PantelKSchlimokGBraunSKutterDLindemannFSchallerGDifferential expression of proliferation-associated molecules in individual micrometastatic carcinoma cellsJ. Natl Cancer Inst.199385141914241:STN:280:DyaK3szltlGntw%3D%3D7688814 – reference: Impact of follow-up testing on survival and health-related quality of life in breast cancer patients. A multicenter randomized controlled trial. The GIVIO Investigators. J. Am. Med. Assoc.271, 1587–1592 (1994). – reference: MilesRCLeeCISunQBansalALymanGHSpechtJMPatterns of surveillance advanced imaging and serum tumor biomarker testing following launch of the choosing wisely initiativeJ. Natl Compr. Canc Netw.2019178138201:CAS:528:DC%2BB3cXhs1CgsLnJ31319393 – reference: SosaMSBragadoPAguirre-GhisoJAMechanisms of disseminated cancer cell dormancy: an awakening fieldNat. Rev. Cancer2014146116221:CAS:528:DC%2BC2cXhtlGnt7%2FP251186024230700 – reference: Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature490, 61–70 (2012). – reference: DieciMVBarbieriEPiacentiniFFicarraGBettelliSDominiciMDiscordance in receptor status between primary and recurrent breast cancer has a prognostic impact: a single-institution analysisAnn. Oncol.2013241011081:STN:280:DC%2BC38bptlCktg%3D%3D23002281 – reference: Harris, J. R., Lippman, M. E., Morrow, M. et al. (eds). Diseases of the Brest, 2nd edn. (J.B. Lippincott, Williams & Wilkins, Philadelphia, 2000). – reference: CristofanilliMBuddGTEllisMJStopeckAMateraJMillerMCCirculating tumor cells, disease progression, and survival in metastatic breast cancerN. Engl. J. Med.20043517817911:CAS:528:DC%2BD2cXntVeitb4%3D15317891 – reference: O’LearyBCuttsRJLiuYHrebienSHuangXFenwickKThe genetic landscape and clonal evolution of breast cancer resistance to palbociclib plus fulvestrant in the PALOMA-3 trialCancer Discov.2018813901403302061106368247 – reference: SottorivaAKangHMaZGrahamTASalomonMPZhaoJA Big Bang model of human colorectal tumor growthNat. Genet.2015472092161:CAS:528:DC%2BC2MXhvFCntbo%3D256650064575589 – reference: RinnerthalerGGampenriederSPGreilRASCO 2018 highlights: metastatic breast cancerMemo201811276279305957536280779 – reference: FolkmanJKalluriRCancer without diseaseNature20044277871:CAS:528:DC%2BD2cXhsFCju7c%3D14985739 – reference: LeeSHKimYSHanWRyuHSChangJMChoNTumor growth rate of invasive breast cancers during wait times for surgery assessed by ultrasonographyMedicine201695e4874276312565402599 – reference: KrishnamurthySCristofanilliMSinghBReubenJGaoHCohenENDetection of minimal residual disease in blood and bone marrow in early stage breast cancerCancer20101163330333720564098 – reference: HüsemannYGeiglJBSchubertFMusianiPMeyerMBurghartESystemic spread is an early step in breast cancerCancer Cell200813586818167340 – reference: Aguirre GhisoJAKovalskiKOssowskiLTumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signalingJ. Cell Biol.1999147891041:STN:280:DyaK1MvjvFOlsg%3D%3D10508858 – reference: SeltzerSCorriganMO’ReillySThe clinicomolecular landscape of de novo versus relapsed stage IV metastatic breast cancerExp. Mol. Pathol.20201141044041:CAS:528:DC%2BB3cXjslygsLg%3D32067942 – reference: ThieryJPAcloqueHHuangRYNietoMAEpithelial-mesenchymal transitions in development and diseaseCell20091398718901:CAS:528:DC%2BC3cXksFWltA%3D%3D19945376 – reference: WongADSearsonPCMitosis-mediated intravasation in a tissue-engineered tumor-microvessel platformCancer Res.201777645364611:CAS:528:DC%2BC2sXhvVSntbbO289238555690825 – reference: Iacobuzio-DonahueCAMichaelCBaezPKappagantulaRHooperJEHollmanTJCancer biology as revealed by the research autopsyNat. Rev. Cancer2019196866971:CAS:528:DC%2BC1MXhslOgtbfM31519982 – reference: FearonERVogelsteinBA genetic model for colorectal tumorigenesisCell1990617597671:CAS:528:DyaK3cXktlyhtrg%3D2188735 – reference: Early Breast Cancer Trialists' Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet365, 1687–1717 (2005). – reference: GerratanaLFanottoVBonottoMBolzonelloSMinisiniAMFasolaGPattern of metastasis and outcome in patients with breast cancerClin. Exp. Metastasis2015321251331:CAS:528:DC%2BC2MXhvFeqs7k%3D25630269 – reference: SchlimokGFunkeIHolzmannBGottlingerGSchmidtGHauserHMicrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1A monoclonal antibodiesProc. Natl Acad. Sci. USA198784867286761:STN:280:DyaL1c%2FmvVKmsw%3D%3D2446326299608 – reference: GeorgescuRBorosMMonceaDBauerOCorosMFOpreaADiscordance rate in estrogen receptor, progesterone receptor, HER2 Status, and Ki67 index between primary unifocal and multiple homogenous breast carcinomas and synchronous axillary lymph node metastases have an impact on therapeutic decisionAppl. Immunohistochem. Mol. Morphol.2018265335381:CAS:528:DC%2BC1cXhs1OntLfL28099174 – reference: Albrengues, J., Shields, M. A., Ng, D., Park, C. G., Ambrico, A., Poindexter, M. E. et al. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science361, 6409 (2018). – reference: Weedon-FekjaerHLindqvistBHVattenLJAalenOOTretliSBreast cancer tumor growth estimated through mammography screening dataBreast Cancer Res.200810184666082481488 – reference: KokkoRHakamaMHolliKFollow-up cost of breast cancer patients with localized disease after primary treatment: a randomized trialBreast Cancer Res. Treat.2005932552601:STN:280:DC%2BD2MrkvFOjtA%3D%3D16132530 – reference: HaqueMMDesaiKVPathways to endocrine therapy resistance in breast cancerFront. Endocrinol.201910573 – reference: AwadaAGligorovJJerusalemGPreusserMSingerCZielinskiCCDK4/6 inhibition in low burden and extensive metastatic breast cancer: summary of an ESMO Open—Cancer Horizons pro and con discussionESMO Open20194e000565317989796863664 – reference: American Society of Clinical Oncology. 2007 Update of recommendations for the use of tumor markers in breast cancer. J. Oncol. Pract. 3, 336–339 (2007). – reference: MarxVHow to pull the blanket off dormant cancer cellsNat. Methods2018152492521:CAS:528:DC%2BC1cXmvVGrsrk%3D29614065 – reference: HosseiniHObradovićMMSHoffmannMHarperKLSosaMSWerner-KleinMEarly dissemination seeds metastasis in breast cancerNature20165405525581:CAS:528:DC%2BC28XitFWntr%2FN279747995390864 – reference: TimmerMWernerJMRöhnGOrtmannMBlauTCramerCDiscordance and conversion rates of progesterone-, estrogen-, and HER2/neu-receptor status in primary breast cancer and brain metastasis mainly triggered by hormone therapyAnticancer Res.201737485948651:CAS:528:DC%2BC1cXitlGhtLbM28870906 – reference: ChiangACMassaguéJMolecular basis of metastasisN. Engl. J. Med.2008359281428231:CAS:528:DC%2BD1cXhsFCnt7bF191095764189180 – reference: Celià-TerrassaTKangYDistinctive properties of metastasis-initiating cellsGenes Dev.201630892908270839974840296 – reference: Aguirre-GhisoJAEstradaYLiuDOssowskiLERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK)Cancer Res.200363168416951:CAS:528:DC%2BD3sXisFahsrY%3D12670923 – reference: PesapaneFDowneyKRotiliACassanoEKohDMImaging diagnosis of metastatic breast cancerInsights Imaging20201179325487317297923 – reference: WeckermannDPolzerBRaggTBlanaASchlimokGArnholdtHPerioperative activation of disseminated tumor cells in bone marrow of patients with prostate cancerJ. Clin. Oncol.2009271549155619237635 – reference: GradisharWJAndersonBOAbrahamJAftRAgneseDAllisonKHBreast cancer, version 3.2020, NCCN clinical practice guidelines in oncologyJ. Natl Compr. Canc Netw.2020184524781:CAS:528:DC%2BB3cXitV2js7bO32259783 – reference: KleinCAParallel progression of primary tumours and metastasesNat. Rev. Cancer200993023121:CAS:528:DC%2BD1MXjsFSrsr8%3D19308069 – reference: SavasPTeoZLLefevreCFlensburgCCaramiaFAlsopKThe subclonal architecture of metastatic breast cancer: results from a prospective community-based rapid autopsy program “CASCADE”PLoS Med.201613e1002204280273125189956 – reference: LangleyRRFidlerIJThe seed and soil hypothesis revisited-the role of tumor-stroma interactions in metastasis to different organsInt. J. Cancer2011128252725351:CAS:528:DC%2BC3MXktVSgt7c%3D213656513075088 – reference: FribergSMattsonSOn the growth rates of human malignant tumors: implications for medical decision makingJ. Surg. Oncol.1997652842971:STN:280:DyaK2svhvVOiuw%3D%3D9274795 – reference: McGranahanNSwantonCClonal heterogeneity and tumor evolution: past, present, and the futureCell20171686136281:CAS:528:DC%2BC2sXis1ygtLg%3D28187284 – reference: BraunSVoglFDNaumeBJanniWOsborneMPCoombesRCA pooled analysis of bone marrow micrometastasis in breast cancerN. Engl. J. Med.20053537938021:CAS:528:DC%2BD2MXovVKlu7s%3D16120859 – reference: Rothenberger, N. J., Somasundaram, A. & Stabile, L. P. The role of the estrogen pathway in the tumor microenvironment. Int. J. Mol. Sci. 19, 611 (2018). – reference: Ferlay, J., Ervik, M., Lam, F., Colombet, M., Mery, L., Piñeros, M. et al. Global Cancer Observatory: Cancer Tomorrow. https://gco.iarc.fr/tomorrow (International Agency for Research on Cancer, Lyon, France, 2018). – reference: SiegelRLMillerKDJemalACancer statistics, 2020CA Cancer J. Clin.20207073031912902 – reference: FaresJFaresMYKhachfeHHSalhabHAFaresYMolecular principles of metastasis: a hallmark of cancer revisitedSignal Transduct. Target Ther.2020528322960477067809 – reference: MillerTWBalkoJMFoxEMGhazouiZDunbierAAndersonHERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancerCancer Discov.201113383511:CAS:528:DC%2BC3MXhtFKnt7vI220493163204388 – reference: HankerABSudhanDRArteagaCLOvercoming endocrine resistance in breast cancerCancer Cell2020374965131:CAS:528:DC%2BB3cXntlSis7k%3D322892737169993 – reference: HarrisLFritscheHMennelRNortonLRavdinPTaubeSAmerican Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancerJ. Clin. Oncol.200725528753121:CAS:528:DC%2BD2sXhsVKnsbzK17954709 – reference: O’LearyBHrebienSMordenJPBeaneyMFribbensCHuangXEarly circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancerNat. Commun.20189294970915832789 – reference: DemicheliRBiganzoliEArdoinoIBoracchiPCoradiniDGrecoMRecurrence and mortality dynamics for breast cancer patients undergoing mastectomy according to estrogen receptor status: different mortality but similar recurrenceCancer Sci.20101018268301:CAS:528:DC%2BC3cXjs1KktrY%3D20132222 – reference: Blomberg, O. S., Spagnuolo, L. & de Visser, K. E. Immune regulation of metastasis: mechanistic insights and therapeutic opportunities. Dis. Model Mech.11, dmm036236 (2018). – reference: WangRZhuYLiuXLiaoXHeJNiuLThe clinicopathological features and survival outcomes of patients with different metastatic sites in stage IV breast cancerBMC Cancer201919317186026852913 – reference: CollinsVPLoefflerRKTiveyHObservations on growth rates of human tumorsAm. J. Roentgenol. Radium Ther. Nucl. Med.19567698810001:STN:280:DyaG2s%2FgvVOktQ%3D%3D13362715 – reference: BestMGWesselingPWurdingerTTumor-educated platelets as a noninvasive biomarker source for cancer detection and progression monitoringCancer Res.201878340734121:CAS:528:DC%2BC1cXht1altbnM29921699 – reference: GuptaGPMassagueJCancer metastasis: building a frameworkCell20061276796951:CAS:528:DC%2BD28Xht1yqs7rL17110329 – reference: TurajlicSSwantonCMetastasis as an evolutionary processScience20163521691751:CAS:528:DC%2BC28XlsFSmu74%3D27124450 – reference: PatelHKBihaniTSelective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatmentPharm. Ther.20181861241:CAS:528:DC%2BC1cXovVShtw%3D%3D – reference: PastushenkoIBrisebarreASifrimAFioramontiMRevencoTBoumahdiSIdentification of the tumour transition states occurring during EMTNature20185564634681:CAS:528:DC%2BC1cXosVCgu74%3D29670281 – reference: KenneckeHYerushalmiRWoodsRCheangMCVoducDSpeersCHMetastatic behavior of breast cancer subtypesJ. Clin. Oncol.2010283271327720498394 – reference: DudaDGDuyvermanAMKohnoMSnuderlMStellerEJFukumuraDMalignant cells facilitate lung metastasis by bringing their own soilProc. Natl Acad. Sci. USA201010721677216821:CAS:528:DC%2BC3cXhs1SqurrM210982743003109 – reference: WeissLMetastatic inefficiencyAdv. Cancer Res.1990541592111:STN:280:DyaK3c7hvFSisw%3D%3D1688681 – reference: HongSPChanTELombardoYCorleoneGRotmenszNBravacciniSSingle-cell transcriptomics reveals multi-step adaptations to endocrine therapyNat. Commun.201910314776986718416 – reference: De PlacidoSDe AngelisCGiulianoMPizziCRuoccoRPerroneVImaging tests in staging and surveillance of non-metastatic breast cancer: changes in routine clinical practice and cost implicationsBr. J. Cancer2017116821827281703715355929 – reference: HarbeckNPenault-LlorcaFCortesJGnantMHoussamiNPoortmansPBreast cancerNat. Rev. Dis. Prim.201956631548545 – reference: CairnsJMutation selection and the natural history of cancerNature19752551972001:CAS:528:DyaE2MXkvFCmsb0%3D1143315 – reference: GhajarCMBissellMJMetastasis: pathways of parallel progressionNature20165405285291:CAS:528:DC%2BC28XitFWntr%2FL27974802 – reference: MüllerVStahmannNRiethdorfSRauTZabelTGoetzACirculating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activityClin. Cancer Res.2005113678368515897564 – reference: MouwJKOuGWeaverVMExtracellular matrix assembly: a multiscale deconstructionNat. Rev. Mol. Cell Biol.2014157717851:CAS:528:DC%2BC2cXhvFKmur7L253706934682873 – reference: DenoixPFNomenclature and classification of cancers based on an atlasActa Unio Int. Contra Cancrum195397697711:STN:280:DyaG2c%2FlvVagsg%3D%3D13138342 – reference: HolmgrenLO’ReillyMSFolkmanJDormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppressionNat. Med.199511491531:CAS:528:DyaK2MXksVeru78%3D7585012 – volume: 353 start-page: 793 year: 2005 ident: 1161_CR110 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa050434 – volume: 5 start-page: 66 year: 2019 ident: 1161_CR117 publication-title: Nat. Rev. Dis. Prim. doi: 10.1038/s41572-019-0111-2 – volume: 139 start-page: 871 year: 2009 ident: 1161_CR73 publication-title: Cell doi: 10.1016/j.cell.2009.11.007 – volume: 11 start-page: 79 year: 2020 ident: 1161_CR159 publication-title: Insights Imaging doi: 10.1186/s13244-020-00885-4 – volume: 5 start-page: 248 year: 2018 ident: 1161_CR31 publication-title: Front. Med. doi: 10.3389/fmed.2018.00248 – volume: 161 start-page: 1046 year: 2015 ident: 1161_CR69 publication-title: Cell doi: 10.1016/j.cell.2015.04.042 – volume: 1 start-page: 338 year: 2011 ident: 1161_CR129 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-11-0101 – volume: 11 start-page: 3678 year: 2005 ident: 1161_CR108 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-04-2469 – volume: 148 start-page: 349 year: 2012 ident: 1161_CR48 publication-title: Cell doi: 10.1016/j.cell.2011.11.025 – volume: 30 start-page: 892 year: 2016 ident: 1161_CR81 publication-title: Genes Dev. doi: 10.1101/gad.277681.116 – volume: 112 start-page: 718 year: 2008 ident: 1161_CR124 publication-title: Cancer doi: 10.1002/cncr.23189 – volume: 4 start-page: 448 year: 2004 ident: 1161_CR3 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1370 – volume: 150 start-page: 534 year: 1992 ident: 1161_CR143 publication-title: J. Cell Physiol. doi: 10.1002/jcp.1041500314 – volume: 25 start-page: 4255 year: 2019 ident: 1161_CR164 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-18-3663 – volume: 9 start-page: 769 year: 1953 ident: 1161_CR29 publication-title: Acta Unio Int. Contra Cancrum – volume: 5 start-page: 28 year: 2020 ident: 1161_CR18 publication-title: Signal Transduct. Target Ther. doi: 10.1038/s41392-020-0134-x – volume: 79 start-page: 1849 year: 2019 ident: 1161_CR118 publication-title: Drugs doi: 10.1007/s40265-019-01208-8 – volume: 13 start-page: 58 year: 2008 ident: 1161_CR47 publication-title: Cancer Cell doi: 10.1016/j.ccr.2007.12.003 – volume: 13 start-page: e1002204 year: 2016 ident: 1161_CR37 publication-title: PLoS Med. doi: 10.1371/journal.pmed.1002204 – volume: 113 start-page: 2422 year: 2008 ident: 1161_CR112 publication-title: Cancer doi: 10.1002/cncr.23852 – volume: 65 start-page: 335 year: 2012 ident: 1161_CR80 publication-title: Adv. Pharm. doi: 10.1016/B978-0-12-397927-8.00011-7 – volume: 78 start-page: 3407 year: 2018 ident: 1161_CR162 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-18-0887 – volume: 11 start-page: 62 year: 2017 ident: 1161_CR23 publication-title: Mol. Oncol. doi: 10.1016/j.molonc.2016.09.009 – volume: 21 start-page: 42 year: 2011 ident: 1161_CR83 publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2010.10.011 – volume: 26 start-page: 798 year: 2008 ident: 1161_CR119 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2007.15.0946 – volume: 18 start-page: 452 year: 2020 ident: 1161_CR149 publication-title: J. Natl Compr. Canc Netw. doi: 10.6004/jnccn.2020.0016 – volume: 26 start-page: 533 year: 2018 ident: 1161_CR135 publication-title: Appl. Immunohistochem. Mol. Morphol. doi: 10.1097/PAI.0000000000000483 – volume: 49 start-page: 111 year: 1998 ident: 1161_CR166 publication-title: Annu. Rev. Med. doi: 10.1146/annurev.med.49.1.111 – volume: 158 start-page: 1110 year: 2014 ident: 1161_CR61 publication-title: Cell doi: 10.1016/j.cell.2014.07.013 – volume: 12 start-page: 875 year: 2006 ident: 1161_CR36 publication-title: Nat. Med. doi: 10.1038/nm0806-875 – volume: 31 start-page: 172 year: 2017 ident: 1161_CR161 publication-title: Cancer Cell doi: 10.1016/j.ccell.2017.01.002 – volume: 128 start-page: 2527 year: 2011 ident: 1161_CR65 publication-title: Int. J. Cancer doi: 10.1002/ijc.26031 – volume: 566 start-page: 553 year: 2019 ident: 1161_CR60 publication-title: Nature doi: 10.1038/s41586-019-0915-y – volume: 13 start-page: 571 year: 2007 ident: 1161_CR156 publication-title: Breast J. doi: 10.1111/j.1524-4741.2007.00506.x – volume: 47 start-page: 209 year: 2015 ident: 1161_CR147 publication-title: Nat. Genet. doi: 10.1038/ng.3214 – ident: 1161_CR100 doi: 10.1038/s43018-020-0088-5 – volume: 24 start-page: 101 year: 2013 ident: 1161_CR134 publication-title: Ann. Oncol. doi: 10.1093/annonc/mds248 – volume: 17 start-page: 813 year: 2019 ident: 1161_CR153 publication-title: J. Natl Compr. Canc Netw. doi: 10.6004/jnccn.2018.7281 – volume: 153 start-page: 865 year: 1998 ident: 1161_CR63 publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)65628-3 – volume: 76 start-page: 988 year: 1956 ident: 1161_CR42 publication-title: Am. J. Roentgenol. Radium Ther. Nucl. Med. – volume: 9 start-page: 285 year: 2009 ident: 1161_CR68 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2621 – volume: 69 start-page: 836 year: 2009 ident: 1161_CR97 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-08-2590 – volume: 19 start-page: 686 year: 2019 ident: 1161_CR144 publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-019-0199-4 – volume: 107 start-page: 21677 year: 2010 ident: 1161_CR59 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1016234107 – volume: 120 start-page: 2030 year: 2010 ident: 1161_CR44 publication-title: J. Clin. Investig. doi: 10.1172/JCI42002 – volume: 255 start-page: 197 year: 1975 ident: 1161_CR41 publication-title: Nature doi: 10.1038/255197a0 – volume: 540 start-page: 588 year: 2016 ident: 1161_CR45 publication-title: Nature doi: 10.1038/nature20609 – ident: 1161_CR128 doi: 10.1038/nature11412 – volume: 31 start-page: 961 year: 2013 ident: 1161_CR150 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2012.45.9859 – volume: 556 start-page: 463 year: 2018 ident: 1161_CR56 publication-title: Nature doi: 10.1038/s41586-018-0040-3 – volume: 8 start-page: 43 year: 2015 ident: 1161_CR51 publication-title: Cancer Growth Metastasis doi: 10.4137/CGM.S31244 – volume: 24 start-page: 2227 year: 2014 ident: 1161_CR115 publication-title: Eur. Radiol. doi: 10.1007/s00330-014-3256-0 – ident: 1161_CR75 doi: 10.3390/cancers11081207 – volume: 37 start-page: 4859 year: 2017 ident: 1161_CR138 publication-title: Anticancer Res. – volume: 85 start-page: 1419 year: 1993 ident: 1161_CR106 publication-title: J. Natl Cancer Inst. doi: 10.1093/jnci/85.17.1419 – volume: 65 start-page: 284 year: 1997 ident: 1161_CR43 publication-title: J. Surg. Oncol. doi: 10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2 – volume: 27 start-page: 1549 year: 2009 ident: 1161_CR105 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2008.17.0563 – volume: 8 start-page: 98 year: 1989 ident: 1161_CR64 publication-title: Cancer Metastasis Rev. – volume: 95 start-page: e4874 year: 2016 ident: 1161_CR114 publication-title: Medicine doi: 10.1097/MD.0000000000004874 – volume: 23 start-page: 5561 year: 2017 ident: 1161_CR131 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-17-0369 – volume: 147 start-page: 89 year: 1999 ident: 1161_CR86 publication-title: J. Cell Biol. doi: 10.1083/jcb.147.1.89 – ident: 1161_CR133 – ident: 1161_CR92 doi: 10.1126/science.aao4227 – volume: 16 start-page: 829 year: 2018 ident: 1161_CR152 publication-title: J. Natl Compr. Canc Netw. doi: 10.6004/jnccn.2018.7024 – volume: 49 start-page: 426 year: 2019 ident: 1161_CR140 publication-title: Jpn. J. Clin. Oncol. doi: 10.1093/jjco/hyz018 – volume: 58 start-page: 180 year: 2008 ident: 1161_CR30 publication-title: CA Cancer J. Clin. doi: 10.3322/CA.2008.0001 – volume: 8 start-page: 1390 year: 2018 ident: 1161_CR167 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-18-0264 – volume: 9 start-page: 345 year: 2015 ident: 1161_CR77 publication-title: Cell Adh Migr. doi: 10.1080/19336918.2015.1059563 – volume: 540 start-page: 528 year: 2016 ident: 1161_CR52 publication-title: Nature doi: 10.1038/nature21104 – volume: 10 year: 2008 ident: 1161_CR113 publication-title: Breast Cancer Res. doi: 10.1186/bcr2092 – volume: 32 start-page: 125 year: 2015 ident: 1161_CR14 publication-title: Clin. Exp. Metastasis doi: 10.1007/s10585-015-9697-2 – volume: 10 year: 2008 ident: 1161_CR103 publication-title: Breast Cancer Res. – volume: 34 start-page: 927 year: 2016 ident: 1161_CR25 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2015.62.3504 – volume: 14 start-page: 1938 year: 2008 ident: 1161_CR146 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-07-4082 – volume: 134 start-page: e48 year: 2010 ident: 1161_CR141 publication-title: Arch. Pathol. Lab. Med. doi: 10.5858/134.7.e48 – volume: 168 start-page: 613 year: 2017 ident: 1161_CR79 publication-title: Cell doi: 10.1016/j.cell.2017.01.018 – volume: 331 start-page: 1559 year: 2011 ident: 1161_CR5 publication-title: Science doi: 10.1126/science.1203543 – volume: 25 start-page: 5287 year: 2007 ident: 1161_CR19 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2007.14.2364 – volume: 55 start-page: 2520 year: 1995 ident: 1161_CR78 publication-title: Cancer Res. – volume: 7 start-page: 834 year: 2007 ident: 1161_CR94 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2256 – ident: 1161_CR62 – volume: 15 start-page: 771 year: 2014 ident: 1161_CR53 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3902 – volume: 427 start-page: 787 year: 2004 ident: 1161_CR95 publication-title: Nature doi: 10.1038/427787a – volume: 8 start-page: 431 year: 2018 ident: 1161_CR74 publication-title: Front. Oncol. doi: 10.3389/fonc.2018.00431 – volume: 351 start-page: 781 year: 2004 ident: 1161_CR111 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa040766 – volume: 70 start-page: 7 year: 2020 ident: 1161_CR2 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21590 – ident: 1161_CR20 doi: 10.1200/JOP.0768504 – volume: 8 start-page: 327ra26 year: 2016 ident: 1161_CR71 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aad6352 – volume: 20 start-page: 483 year: 2015 ident: 1161_CR127 publication-title: Oncologist doi: 10.1634/theoncologist.2014-0443 – volume: 191 start-page: 65 year: 2018 ident: 1161_CR130 publication-title: Pharm. Ther. doi: 10.1016/j.pharmthera.2018.06.008 – volume: 20 start-page: 701 year: 2015 ident: 1161_CR137 publication-title: Int. J. Clin. Oncol. doi: 10.1007/s10147-014-0759-2 – volume: 54 start-page: 6504 year: 1994 ident: 1161_CR102 publication-title: Cancer Res. – volume: 3 start-page: 362 year: 2003 ident: 1161_CR55 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1075 – ident: 1161_CR148 – volume: 101 start-page: 826 year: 2010 ident: 1161_CR26 publication-title: Cancer Sci. doi: 10.1111/j.1349-7006.2009.01472.x – volume: 116 start-page: 821 year: 2017 ident: 1161_CR151 publication-title: Br. J. Cancer doi: 10.1038/bjc.2017.24 – volume: 19 year: 2019 ident: 1161_CR15 publication-title: BMC Cancer – volume: 93 start-page: 255 year: 2005 ident: 1161_CR155 publication-title: Breast Cancer Res. Treat. doi: 10.1007/s10549-005-5199-2 – volume: 540 start-page: 552 year: 2016 ident: 1161_CR46 publication-title: Nature doi: 10.1038/nature20785 – volume: 116 start-page: 3330 year: 2010 ident: 1161_CR50 publication-title: Cancer doi: 10.1002/cncr.25145 – volume: 77 start-page: 6453 year: 2017 ident: 1161_CR57 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-16-3279 – volume: 16 year: 2014 ident: 1161_CR122 publication-title: Breast Cancer Res. doi: 10.1186/s13058-014-0489-4 – volume: 186 start-page: 1 year: 2018 ident: 1161_CR123 publication-title: Pharm. Ther. doi: 10.1016/j.pharmthera.2017.12.012 – volume: 4 start-page: e000565 year: 2019 ident: 1161_CR126 publication-title: ESMO Open doi: 10.1136/esmoopen-2019-000565 – volume: 63 start-page: 1684 year: 2003 ident: 1161_CR89 publication-title: Cancer Res. – volume: 9 start-page: 302 year: 2009 ident: 1161_CR33 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2627 – volume: 15 start-page: 249 year: 2018 ident: 1161_CR82 publication-title: Nat. Methods doi: 10.1038/nmeth.4640 – volume: 70 start-page: 5649 year: 2010 ident: 1161_CR34 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-10-1040 – volume: 29 start-page: 1214 year: 2010 ident: 1161_CR88 publication-title: Oncogene doi: 10.1038/onc.2009.419 – ident: 1161_CR1 – volume: 147 start-page: 275 year: 2011 ident: 1161_CR4 publication-title: Cell doi: 10.1016/j.cell.2011.09.024 – volume: 359 start-page: 2814 year: 2008 ident: 1161_CR11 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra0805239 – volume: 481 start-page: 85 year: 2011 ident: 1161_CR109 publication-title: Nature doi: 10.1038/nature10694 – volume: 10 start-page: 573 year: 2019 ident: 1161_CR125 publication-title: Front. Endocrinol. doi: 10.3389/fendo.2019.00573 – volume: 9 start-page: 498 year: 2019 ident: 1161_CR99 publication-title: Front. Oncol. doi: 10.3389/fonc.2019.00498 – volume: 53 start-page: 1192 year: 2011 ident: 1161_CR91 publication-title: Hepatology doi: 10.1002/hep.24108 – volume: 84 start-page: 8672 year: 1987 ident: 1161_CR104 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.84.23.8672 – volume: 406 start-page: 747 year: 2000 ident: 1161_CR21 publication-title: Nature doi: 10.1038/35021093 – volume: 1 start-page: 149 year: 1995 ident: 1161_CR96 publication-title: Nat. Med. doi: 10.1038/nm0295-149 – volume: 114 start-page: 403 year: 2009 ident: 1161_CR158 publication-title: Breast Cancer Res. Treat. doi: 10.1007/s10549-008-0023-4 – ident: 1161_CR9 doi: 10.1016/S0140-6736(05)66544-0 – volume: 4 start-page: e83 year: 2006 ident: 1161_CR84 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0040083 – ident: 1161_CR157 doi: 10.1001/jama.271.20.1587 – volume: 127 start-page: 679 year: 2006 ident: 1161_CR6 publication-title: Cell doi: 10.1016/j.cell.2006.11.001 – volume: 20 start-page: 701 year: 2011 ident: 1161_CR93 publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.11.002 – ident: 1161_CR49 – volume: 60 start-page: 2541 year: 2000 ident: 1161_CR66 publication-title: Cancer Res. – volume: 37 start-page: 496 year: 2020 ident: 1161_CR120 publication-title: Cancer Cell doi: 10.1016/j.ccell.2020.03.009 – volume: 16 start-page: e133 year: 2016 ident: 1161_CR142 publication-title: Clin. Breast Cancer doi: 10.1016/j.clbc.2016.05.014 – volume: 295 start-page: 211 year: 2017 ident: 1161_CR116 publication-title: Arch. Gynecol. Obstet. doi: 10.1007/s00404-016-4225-4 – volume: 291 start-page: 19351 year: 2016 ident: 1161_CR85 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M116.737379 – volume: 10 year: 2019 ident: 1161_CR121 publication-title: Nat. Commun. – volume: 21 start-page: 50 year: 2012 ident: 1161_CR27 publication-title: Breast doi: 10.1016/j.breast.2011.07.008 – volume: 27 start-page: 16 year: 2014 ident: 1161_CR98 publication-title: Curr. Opin. Immunol. doi: 10.1016/j.coi.2014.01.004 – volume: 15 start-page: 807 year: 2013 ident: 1161_CR101 publication-title: Nat. Cell Biol. doi: 10.1038/ncb2767 – volume: 20 start-page: 71 year: 2019 ident: 1161_CR163 publication-title: Nat. Rev. Genet. doi: 10.1038/s41576-018-0071-5 – volume: 352 start-page: 169 year: 2016 ident: 1161_CR35 publication-title: Science doi: 10.1126/science.aaf2784 – volume: 12 start-page: 863 year: 2001 ident: 1161_CR90 publication-title: Mol. Biol. Cell doi: 10.1091/mbc.12.4.863 – volume: 91 start-page: 80 year: 1999 ident: 1161_CR24 publication-title: J. Natl Cancer Inst. doi: 10.1093/jnci/91.1.80 – volume: 17 start-page: 302 year: 2017 ident: 1161_CR67 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc.2017.6 – volume: 14 start-page: 611 year: 2014 ident: 1161_CR17 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3793 – volume: 46 start-page: 1181 year: 2010 ident: 1161_CR87 publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2010.02.027 – volume: 10 start-page: 8152 year: 2004 ident: 1161_CR107 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-04-1110 – volume: 114 start-page: 104404 year: 2020 ident: 1161_CR7 publication-title: Exp. Mol. Pathol. doi: 10.1016/j.yexmp.2020.104404 – volume: 11 start-page: 40 year: 2017 ident: 1161_CR58 publication-title: Mol. Oncol. doi: 10.1002/1878-0261.12022 – volume: 13 start-page: 853 year: 2020 ident: 1161_CR139 publication-title: OncoTargets Ther. doi: 10.2147/OTT.S231493 – volume: 2 start-page: pky062 year: 2018 ident: 1161_CR8 publication-title: JNCI Cancer Spectr. doi: 10.1093/jncics/pky062 – volume: 3 start-page: 138 year: 2012 ident: 1161_CR38 publication-title: World J. Oncol. – volume: 25 start-page: 2559 year: 2011 ident: 1161_CR70 publication-title: Genes Dev. doi: 10.1101/gad.169029.111 – volume: 9 year: 2018 ident: 1161_CR168 publication-title: Nat. Commun. doi: 10.1038/s41467-018-03215-x – volume: 108 start-page: 12396 year: 2011 ident: 1161_CR16 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1106613108 – volume: 5 start-page: 1473 year: 2019 ident: 1161_CR165 publication-title: JAMA Oncol. doi: 10.1001/jamaoncol.2019.1838 – volume: 56 start-page: 102793 year: 2020 ident: 1161_CR39 publication-title: eBioMedicine doi: 10.1016/j.ebiom.2020.102793 – ident: 1161_CR10 – volume: 61 start-page: 759 year: 1990 ident: 1161_CR40 publication-title: Cell doi: 10.1016/0092-8674(90)90186-I – volume: 11 start-page: 276 year: 2018 ident: 1161_CR160 publication-title: Memo doi: 10.1007/s12254-018-0450-9 – volume: 9 start-page: 23 year: 2015 ident: 1161_CR13 publication-title: Breast Cancer – volume: 22 start-page: 1736 year: 2011 ident: 1161_CR22 publication-title: Ann. Oncol. doi: 10.1093/annonc/mdr304 – volume: 137 start-page: 295 year: 2018 ident: 1161_CR136 publication-title: J. Neurooncol. doi: 10.1007/s11060-017-2717-0 – volume: 54 start-page: 159 year: 1990 ident: 1161_CR76 publication-title: Adv. Cancer Res. doi: 10.1016/S0065-230X(08)60811-8 – volume: 28 start-page: 3271 year: 2010 ident: 1161_CR28 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2009.25.9820 – volume: 14 start-page: 3643 year: 2008 ident: 1161_CR145 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-08-1135 – volume: 154 start-page: 214 year: 2013 ident: 1161_CR154 publication-title: Surgery doi: 10.1016/j.surg.2013.04.004 – ident: 1161_CR72 – volume: 3 start-page: 453 year: 2003 ident: 1161_CR12 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1098 – volume: 389 start-page: 1134 year: 2017 ident: 1161_CR32 publication-title: Lancet doi: 10.1016/S0140-6736(16)31891-8 – volume: 352 start-page: 167 year: 2016 ident: 1161_CR54 publication-title: Science doi: 10.1126/science.aaf6546 – ident: 1161_CR132 doi: 10.1101/cshperspect.a006098 – reference: 36316559 - Br J Cancer. 2023 Feb;128(3):484-485 |
| SSID | ssj0009087 |
| Score | 2.7147942 |
| SecondaryResourceType | review_article |
| Snippet | Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic... |
| SourceID | pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 13 |
| SubjectTerms | 631/67/322 692/4028/67/1347 Animals Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - pathology Cancer Research Drug Resistance Epidemiology Female Humans Metastases Metastasis Molecular Medicine Neoplasm Invasiveness - pathology Neoplasm Metastasis - pathology Neoplasm Recurrence, Local - pathology Oncology Review Review Article Surgery |
| Title | The lingering mysteries of metastatic recurrence in breast cancer |
| URI | https://link.springer.com/article/10.1038/s41416-020-01161-4 https://www.ncbi.nlm.nih.gov/pubmed/33239679 https://www.proquest.com/docview/2474990342 https://www.proquest.com/docview/2464605801 https://pubmed.ncbi.nlm.nih.gov/PMC7782773 |
| Volume | 124 |
| WOSCitedRecordID | wos000592594000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1532-1827 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0009087 issn: 0007-0920 databaseCode: M7P dateStart: 20190101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1532-1827 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0009087 issn: 0007-0920 databaseCode: 7X7 dateStart: 20190101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1532-1827 dateEnd: 20241214 omitProxy: false ssIdentifier: ssj0009087 issn: 0007-0920 databaseCode: 7RV dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1532-1827 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0009087 issn: 0007-0920 databaseCode: BENPR dateStart: 20190101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1532-1827 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0009087 issn: 0007-0920 databaseCode: 8C1 dateStart: 20190101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5Bi1Av5U1TyspI3MBqYiexfapK1YoLq1UFaG9R_BIrtdmym_L78TjeXW0reuHiix059ow93zw8A_Cxcjw3hWZU2drTUmhHlWMF5dJbo3KnrfGx2IQYj-V0qibJ4LZMYZWrOzFe1HZu0EZ-zEoRwDkmrDu5-U2xahR6V1MJjcewi2Wzkc_FVGyS7uZyyJmJ5jjF8vRoJufyeFkWAYpQVJ7QFRH0qG3BdA9t3g-avOM5jQLp4tn_LuU57CcoSk4H3nkBj1z3Ep5-S872V3AaWIhcxblDQ64x5zMq1mTuybXrW3yLNDNkgRb7-GaQzDqiMci9JwaZafEaflycfz_7SlPFBWoCcuuptTrgOa1M0PqYLaNANzzciUHQ86qtZS2lrWumSp0bp5TzNkg7b1rBbFsZwd_ATjfv3AEQzxxCFR8QgSu9N1L5iuU4QdD4rNYZFKvtbkxKR45VMa6a6BbnshlI1AQSNZFETZnBp_U3N0MyjgdHH622v0kHc9ls9j6DD-vucKTQT9J2bn6LY-roLc6LDN4ORF9PxznjqhYqA7HFDusBmK57u6eb_Yppu0UAY0LwDD6vGGfzW_9exeHDq3gHewyjbNAoVB3BTr-4de_hifnTz5aLUTgOlz9H8VDEVoZWnhUj2P1yPp5cjjDSdfIXUgwVCg |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VgoALb0qggJHgRKMmdhLbB4SqQtWq7YpDkXoLiR9ipTbb7qYg_hS_kRkn2dVS0VsPXHKx83D8zfgbz3gG4G3uRGLSmsfaFj7OZO1i7XgaC-Wt0YmrrfGh2IQcjdTxsf6yAr-HszAUVjnoxKCo7cTQHvkmzySSc0pY9_HsPKaqUeRdHUpodLDYd79-osk2-7D3Cef3Hec7n4-2d-O-qkBskJ20sbU1cpZaG7RsuM3ComUEyj0uZiKvClUoZYuC66xOjNPaeYsa3ZtKclvlRgp87g24mQkuSIrU9iKkRCeqy9FJ23-aJ_0hnUSozVmWIvWJyVgj1wfabcsL4SV2ezlI8y9PbVgAd-7_b7_uAdzrqTbb6mTjIay45hHcPuyDCR7DFooIOwljxQs7pZzWtHHAJp6durais1Zjw6bkkQhnItm4YTUF8bfMkLBMn8DXaxnAU1htJo17BsxzR1TMI-NxmfdGaZ_zhF6AFq2t6wjSYXpL06dbp6ofJ2Vw-wtVdpAoERJlgESZRfB-fs9Zl2zkyt7rw3SXveKZlYu5juDNvBlVBvmBqsZNLqhPEbzhSRrBWgey-esEwbqQOgK5BL95B0pHvtzSjL-HtOQSyaaUIoKNAaiLz_r3KJ5fPYrXcGf36PCgPNgb7b-Au5wiimgDLF-H1XZ64V7CLfOjHc-mr4IoMvh23QD-A_-6ap0 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VLap64Q0NFDASnCDaxE7i-IBQoV1RFVYrBFJvIfFDrNRmy24K4q_x65hxkl0tFb31wCUXOw_Hn8ffPDwD8Dy1ItJxxUNlMhcmsrKhsjwORe6MVpGtjHa-2IQcj_PjYzXZgN_9WRgKq-xlohfUZqbJRj7kiURyTgnrhq4Li5jsj96cfQ-pghR5WvtyGi1Ejuyvn6i-LV4f7uNcv-B8dPD53fuwqzAQamQqTWhMhfylUhq1HG4Sv4FpgTIANzaRllme5bnJMq6SKtJWKesMSnenS8lNmWop8LnXYFMKVHoGsPn2YDz5tEr5G-Vtxk4yBioedUd2IpEPF0mMRCgk1Y0cIajFrW-LF7juxZDNv_y2fjsc3fyff-QtuNGRcLbXrprbsGHrO7D1sQszuAt7uHjYiR83XtgpZbsmkwKbOXZqm5JOYU01m5Ovwp-WZNOaVRTe3zBNy2h-D75cyQDuw6Ce1XYHmOOWSJpDLmQT53SuXMojegHquqaqAoj7qS50l4id6oGcFD4gQORFC48C4VF4eBRJAC-X95y1aUgu7b3bT33RiaRFsZr3AJ4tm1GYkIeorO3snPpk3k8exQE8aAG3fJ0QXKhMqgDkGhSXHShR-XpLPf3mE5ZLpKFSigBe9aBdfda_R_Hw8lE8hS3EbfHhcHz0CLY5hRqRZSzdhUEzP7eP4br-0UwX8yfdumTw9aoR_AfXdnT7 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+lingering+mysteries+of+metastatic+recurrence+in+breast+cancer&rft.jtitle=British+journal+of+cancer&rft.au=Riggio%2C+Alessandra+I.&rft.au=Varley%2C+Katherine+E.&rft.au=Welm%2C+Alana+L.&rft.date=2021-01-05&rft.pub=Nature+Publishing+Group+UK&rft.issn=0007-0920&rft.eissn=1532-1827&rft.volume=124&rft.issue=1&rft.spage=13&rft.epage=26&rft_id=info:doi/10.1038%2Fs41416-020-01161-4&rft.externalDocID=10_1038_s41416_020_01161_4 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0007-0920&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0007-0920&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0007-0920&client=summon |