The lingering mysteries of metastatic recurrence in breast cancer

Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic disease typically manifests after a protracted period of undetectable disease following surgery or systemic therapy, owing to relapse or recurre...

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Bibliographic Details
Published in:British journal of cancer Vol. 124; no. 1; pp. 13 - 26
Main Authors: Riggio, Alessandra I., Varley, Katherine E., Welm, Alana L.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 05.01.2021
Nature Publishing Group
Subjects:
631/67/322
692/4028/67/1347
Animals
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - pathology
Cancer Research
Drug Resistance
Epidemiology
Female
Humans
Metastases
Metastasis
Molecular Medicine
Neoplasm Invasiveness - pathology
Neoplasm Metastasis - pathology
Neoplasm Recurrence, Local - pathology
Oncology
Review
Review Article
Surgery
ISSN:0007-0920, 1532-1827, 1532-1827
Online Access:Get full text
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Summary:Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic disease typically manifests after a protracted period of undetectable disease following surgery or systemic therapy, owing to relapse or recurrence. In the case of breast cancer, metastatic relapse can occur months to decades after initial diagnosis and treatment. In this review, we provide an overview of the known key factors that influence metastatic recurrence, with the goal of highlighting the critical unanswered questions that still need to be addressed to make a difference in the mortality of breast cancer patients.
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ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-020-01161-4