Normalization by valence and motivational intensity in the sensorimotor cortices (PMd, M1, and S1)

Our brain’s ability to represent vast amounts of information, such as continuous ranges of reward spanning orders of magnitude, with limited dynamic range neurons, may be possible due to normalization. Recently our group and others have shown that the sensorimotor cortices are sensitive to reward va...

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Veröffentlicht in:Scientific reports Jg. 11; H. 1; S. 24221 - 19
Hauptverfasser: Yao, Zhao, Hessburg, John P., Francis, Joseph Thachil
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 20.12.2021
Nature Publishing Group
Nature Portfolio
Schlagworte:
631/378/1457
631/378/1662
631/378/1788
631/378/2632
Action Potentials - physiology
Affect (Psychology)
Animals
Behavior, Animal
Brain
Brain Mapping - methods
Electrodes
Emotions
Female
Grasping
Hand Strength
Humanities and Social Sciences
Kinematics
Laboratory animals
Linear Models
Macaca mulatta
Macaca radiata
Male
Motivation
Motor Cortex - physiology
Movement - physiology
multidisciplinary
Neurons - physiology
Psychomotor Performance - physiology
Punishment
Reaction Time - physiology
Reinforcement
Reproducibility of Results
Reward
Robotics
Science
Science (multidisciplinary)
Sensorimotor Cortex - physiology
Sensorimotor system
ISSN:2045-2322, 2045-2322
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Zusammenfassung:Our brain’s ability to represent vast amounts of information, such as continuous ranges of reward spanning orders of magnitude, with limited dynamic range neurons, may be possible due to normalization. Recently our group and others have shown that the sensorimotor cortices are sensitive to reward value. Here we ask if psychological affect causes normalization of the sensorimotor cortices by modulating valence and motivational intensity. We had two non-human primates (NHP) subjects (one male bonnet macaque and one female rhesus macaque) make visually cued grip-force movements while simultaneously cueing the level of possible reward if successful, or timeout punishment, if unsuccessful. We recorded simultaneously from 96 electrodes in each the following: caudal somatosensory, rostral motor, and dorsal premotor cortices (cS1, rM1, PMd). We utilized several normalization models for valence and motivational intensity in all three regions. We found three types of divisive normalized relationships between neural activity and the representation of valence and motivation, linear, sigmodal, and hyperbolic. The hyperbolic relationships resemble receptive fields in psychological affect space, where a unit is susceptible to a small range of the valence/motivational space. We found that these cortical regions have both strong valence and motivational intensity representations.
Bibliographie:ObjectType-Article-1
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-03200-3