Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population

Recent studies in animal models and humans show that long non-coding RNAs (lncRNAs) are involved in the development of atherosclerosis, which contributes to the pathological foundation of coronary artery disease (CAD). LncRNAs in plasma and serum have been considered as promising novel biomarkers fo...

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Vydáno v:	Scientific reports Ročník 7; číslo 1; s. 7491 - 9
Hlavní autoři:	Zhang, Zhen, Gao, Wei, Long, Qing-Qing, Zhang, Jian, Li, Ya-Fei, liu, Dong-Chen, Yan, Jian-Jun, Yang, Zhi-Jian, Wang, Lian-Sheng
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 08.08.2017 Nature Publishing Group Nature Portfolio
Témata:	38 38/77 631/208/721 692/53 Adult Aged Animal models Area Under Curve Arteriosclerosis Asian Continental Ancestry Group Atherosclerosis Atrial Remodeling - genetics Biomarkers Biomarkers - blood Cardiovascular disease Cardiovascular diseases Case-Control Studies Coronary artery Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - ethnology Coronary Artery Disease - genetics Coronary vessels Female Health risk assessment Health risks Heart diseases Heart Failure - blood Heart Failure - diagnosis Heart Failure - ethnology Heart Failure - genetics Humanities and Social Sciences Humans Logistic Models Male Middle Aged multidisciplinary Multivariate Analysis Non-coding RNA Plasma Plasma levels Polymerase chain reaction Population studies Prognosis Reverse transcription Risk Risk factors RNA, Long Noncoding - blood RNA, Long Noncoding - genetics ROC Curve Science Science (multidisciplinary) Ventricular Remodeling - genetics
ISSN:	2045-2322, 2045-2322
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Shrnutí:	Recent studies in animal models and humans show that long non-coding RNAs (lncRNAs) are involved in the development of atherosclerosis, which contributes to the pathological foundation of coronary artery disease (CAD). LncRNAs in plasma and serum have been considered as promising novel biomarkers for diagnosis and prognosis of cardiovascular diseases, especially CAD. We here measured the circulating levels of 8 individual lncRNAs which are known to be relevant to atherosclerosis in the plasma samples from 300 patients with CAD and 180 control subjects by using quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) methods. We found that the plasma level of H19 and long intergenic non-coding RNA predicting cardiac remodeling (LIPCAR) were significantly increased in patients with CAD. The area under the receiver operating characteristic curve was 0.631 for H19 and 0.722 for LIPCAR. Multivariate logistic regression analyses indicated that plasma H19 and LIPCAR were independent predictors for CAD, even after adjustment for traditional cardiovascular risk factors. Further studies identified that plasma levels of H19 and LIPCAR were also increased in CAD patients with heart failure compared to those with normal cardiac function. Taken together, our results suggest that increased plasma levels of H19 and LIPCAR are associated with increased risk of CAD and may be considered as novel biomarkers for CAD.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-017-07611-z