Robust decomposition of cell type mixtures in spatial transcriptomics

A limitation of spatial transcriptomics technologies is that individual measurements may contain contributions from multiple cells, hindering the discovery of cell-type-specific spatial patterns of localization and expression. Here, we develop robust cell type decomposition (RCTD), a computational m...

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Vydané v:	Nature biotechnology Ročník 40; číslo 4; s. 517 - 526
Hlavní autori:	Cable, Dylan M., Murray, Evan, Zou, Luli S., Goeva, Aleksandrina, Macosko, Evan Z., Chen, Fei, Irizarry, Rafael A.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Nature Publishing Group US 01.04.2022 Nature Publishing Group
Predmet:	631/114/2415 631/61 631/61/212 631/61/212/2019 Agriculture Animals Bioinformatics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Computational neuroscience Datasets Decomposition Exome Sequencing Life Sciences Localization Mapping Mice Mixtures Sequence Analysis, RNA Single-Cell Analysis Software Tissues Transcriptome - genetics Transcriptomics
ISSN:	1087-0156, 1546-1696, 1546-1696
On-line prístup:	Získať plný text
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