Reversible interactions with para-hydrogen enhance NMR sensitivity by polarization transfer

The sensitivity of both nuclear magnetic resonance spectroscopy and magnetic resonance imaging is very low because the detected signal strength depends on the small population difference between spin states even in high magnetic fields. Hyperpolarization methods can be used to increase this differen...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Science (American Association for the Advancement of Science) Ročník 323; číslo 5922; s. 1708
Hlavní autori: Adams, Ralph W, Aguilar, Juan A, Atkinson, Kevin D, Cowley, Michael J, Elliott, Paul I P, Duckett, Simon B, Green, Gary G R, Khazal, Iman G, López-Serrano, Joaquín, Williamson, David C
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 27.03.2009
Predmet:
Carbon - analysis
Hydrogen - chemistry
Iridium - chemistry
Ligands
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Niacinamide - chemistry
Nitrogen - analysis
Protons
Pyridines - chemistry
Sensitivity and Specificity
ISSN:1095-9203, 1095-9203
On-line prístup:Zistit podrobnosti o prístupe
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:The sensitivity of both nuclear magnetic resonance spectroscopy and magnetic resonance imaging is very low because the detected signal strength depends on the small population difference between spin states even in high magnetic fields. Hyperpolarization methods can be used to increase this difference and thereby enhance signal strength. This has been achieved previously by incorporating the molecular spin singlet para-hydrogen into hydrogenation reaction products. We show here that a metal complex can facilitate the reversible interaction of para-hydrogen with a suitable organic substrate such that up to an 800-fold increase in proton, carbon, and nitrogen signal strengths are seen for the substrate without its hydrogenation. These polarized signals can be selectively detected when combined with methods that suppress background signals.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1095-9203
1095-9203
DOI:10.1126/science.1168877