The anti-malarial drug atovaquone potentiates platinum-mediated cancer cell death by increasing oxidative stress

Platinum chemotherapies are highly effective cytotoxic agents but often induce resistance when used as monotherapies. Combinatorial strategies limit this risk and provide effective treatment options for many cancers. Here, we repurpose atovaquone (ATQ), a well-tolerated & FDA-approved anti-malar...

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Bibliographic Details
Published in:	Cell death discovery Vol. 6; no. 1; p. 110
Main Authors:	Coates, James T. T., Rodriguez-Berriguete, Gonzalo, Puliyadi, Rathi, Ashton, Thomas, Prevo, Remko, Wing, Archie, Granata, Giovanna, Pirovano, Giacomo, McKenna, Gillies W., Higgins, Geoff S.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.10.2020 Springer Nature B.V
Subjects:	631/67/1059/99 692/308/2778 Acetylcysteine Apoptosis Atovaquone Biochemistry Biomedical and Life Sciences Cancer Carboplatin Cell Biology Cell Cycle Analysis Cell death Chemotherapy Cisplatin Cytotoxic agents Cytotoxicity Electron transport chain Glutathione Hypoxia Life Sciences Mitochondria Oxidative stress Platinum Reactive oxygen species Spheroids Stem Cells Superoxide dismutase Tumor cell lines Chemotherapy Preclinical research
ISSN:	2058-7716, 2058-7716
Online Access:	Get full text
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