Biological roles of adenine methylation in RNA

N -Methyladenosine (m A) is one of the most abundant modifications of the epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in detection and mapping methods have improved our understanding of the effects of m A on mRNA fate and ribosomal RNA function, and have unco...

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Bibliographic Details
Published in:Nature reviews. Genetics Vol. 24; no. 3; pp. 143 - 160
Main Authors: Boulias, Konstantinos, Greer, Eric Lieberman
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.03.2023
Subjects:
Adenine
Adenosine
Cell differentiation
Chromatin
Epigenetics
Gene expression
Gene mapping
Gene regulation
Methylation
MicroRNAs
N6-methyladenosine
Neurogenesis
Proteins
RNA - metabolism
RNA polymerase
RNA Processing, Post-Transcriptional
RNA, Messenger - genetics
rRNA
Stem cells
Transfer RNA
ISSN:1471-0056, 1471-0064, 1471-0064
Online Access:Get full text
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Summary:N -Methyladenosine (m A) is one of the most abundant modifications of the epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in detection and mapping methods have improved our understanding of the effects of m A on mRNA fate and ribosomal RNA function, and have uncovered novel functional roles in virtually every species of RNA. In this Review, we explore the latest studies revealing roles for m A-modified RNAs in chromatin architecture, transcriptional regulation and genome stability. We also summarize m A functions in biological processes such as stem-cell renewal and differentiation, brain function, immunity and cancer progression.
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ISSN:1471-0056
1471-0064
1471-0064
DOI:10.1038/s41576-022-00534-0