Memory T cells: strategies for optimizing tumor immunotherapy

Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells. Furthermore, the Tcm/Teff ratio has been reported...

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Bibliographic Details
Published in:Protein & cell Vol. 11; no. 8; pp. 549 - 564
Main Authors: Liu, Qingjun, Sun, Zhongjie, Chen, Ligong
Format: Journal Article
Language:English
Published: Beijing Higher Education Press 01.08.2020
Springer Nature B.V
Oxford University Press
Subjects:
Animals
Antitumor activity
Biochemistry
Biomedical and Life Sciences
Cell Biology
Developmental Biology
Effector cells
gut microbiota
Human Genetics
Humans
Immune response
Immunologic Memory
Immunological memory
Immunotherapy
Intestinal microflora
Life Sciences
Lymphocytes
Lymphocytes T
Memory cells
memory T cells
metabolism
Microbiota
Neoplasms - immunology
Neoplasms - therapy
Protein Science
Review
Stem Cells
T-Lymphocytes - immunology
tumor immunology
Tumors
metabolism
tumor immunology
memory T cells
gut microbiota
ISSN:1674-800X, 1674-8018, 1674-8018
Online Access:Get full text
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Summary:Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells. Furthermore, the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors. Thus, a system-level understanding of the mechanisms underlying the differentiation of effector and memory T cells is of increasing importance for developing immunological strategies against various tumors. This review focuses on recent advances in efficacy against tumors, the origin, formation mechanisms of memory T cells, and the role of the gut microbiota in memory T cell formation. Furthermore, we summarize strategies to generate memory T cells in ( ex ) vivo that, might be applicable in clinical practice.
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ISSN:1674-800X
1674-8018
1674-8018
DOI:10.1007/s13238-020-00707-9