Endocytosis: a pivotal pathway for regulating metastasis

A potentially important aspect in the regulation of tumour metastasis is endocytosis. This process consists of internalisation of cell-surface receptors via pinocytosis, phagocytosis or receptor-mediated endocytosis, the latter of which includes clathrin-, caveolae- and non-clathrin or caveolae-medi...

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Vydáno v:British journal of cancer Ročník 124; číslo 1; s. 66 - 75
Hlavní autoři: Khan, Imran, Steeg, Patricia S.
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 05.01.2021
Nature Publishing Group
Témata:
631/67/1347
631/67/322
631/67/322/803
631/80/84/2336
Biomedical and Life Sciences
Biomedicine
Cancer Research
Caveolae
Cell Movement - physiology
Cell surface
Clathrin
Drug Resistance
Endocytosis
Endocytosis - physiology
Epidemiology
Humans
Lysosomes
Metastases
Metastasis
Molecular Medicine
Neoplasm Invasiveness - pathology
Neoplasms - metabolism
Neoplasms - pathology
Oncology
Phagocytosis
Pinocytosis
Protein turnover
Review
Review Article
Signal transduction
Tumors
ISSN:0007-0920, 1532-1827, 1532-1827
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Shrnutí:A potentially important aspect in the regulation of tumour metastasis is endocytosis. This process consists of internalisation of cell-surface receptors via pinocytosis, phagocytosis or receptor-mediated endocytosis, the latter of which includes clathrin-, caveolae- and non-clathrin or caveolae-mediated mechanisms. Endocytosis then progresses through several intracellular compartments for sorting and routing of cargo, ending in lysosomal degradation, recycling back to the cell surface or secretion. Multiple endocytic proteins are dysregulated in cancer and regulate tumour metastasis, particularly migration and invasion. Importantly, four metastasis suppressor genes function in part by regulating endocytosis, namely, the NME, KAI, MTSS1 and KISS1 pathways. Data on metastasis suppressors identify a new point of dysregulation operative in tumour metastasis, alterations in signalling through endocytosis. This review will focus on the multicomponent process of endocytosis affecting different steps of metastasis and how metastatic-suppressor genes use endocytosis to suppress metastasis.
Bibliografie:ObjectType-Article-1
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ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-020-01179-8