Fusion-mediated chromosomal instability promotes aneuploidy patterns that resemble human tumors

Oncogenesis is considered to result from chromosomal instability, in addition to oncogene and tumor-suppressor alterations. Intermediate to aneuploidy and chromosomal instability, genome doubling is a frequent event in tumor development but the mechanisms driving tetraploidization and its impact rem...

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Bibliographic Details
Published in:	Oncogene Vol. 38; no. 33; pp. 6083 - 6094
Main Authors:	Delespaul, Lucile, Merle, Candice, Lesluyes, Tom, Lagarde, Pauline, Le Guellec, Sophie, Pérot, Gaëlle, Baud, Jessica, Carlotti, Martina, Danet, Coralie, Fèvre, Murielle, Rousseau, Benoit, Durrieu, Stéphanie, Teichmann, Martin, Coindre, Jean-Michel, Lartigue, Lydia, Chibon, Frédéric
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15.08.2019 Nature Publishing Group Nature Publishing Group [1987-....]
Subjects:	13/1 13/106 13/109 13/31 13/51 14/32 14/63 45/22 45/61 45/77 631/208/211 631/67/1798 631/67/2329 631/67/69 631/67/70 64/110 Aneuploidy Animals Apoptosis Cancer Carcinogenesis Care and treatment Cell Biology Cell differentiation Cell Fusion Cell Transformation, Neoplastic - genetics Cells, Cultured Chromosomal Instability - physiology Development and progression Genetic aspects Genomes Genomic Instability Health aspects Human Genetics Humans Hybrid Cells - cytology Hybrid Cells - metabolism Internal Medicine Latency Life Sciences Medicine Medicine & Public Health Membrane fusion Mesenchyme Mice Mice, Inbred NOD Mice, Transgenic Neoplasms - genetics Neoplasms - pathology Oncology Risk factors Structure Tetraploidy Tumorigenesis Tumors France
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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