The Immune Microenvironment in Head and Neck Squamous Cell Carcinoma: on Subsets and Subsites

Purpose To understand why some patients respond to immunotherapy but many do not, a clear picture of the tumor microenvironment (TME) of head and neck squamous cell carcinoma (HNSCC) is key. Here we review the current understanding on the immune composition per HNSCC subsite, the importance of the t...

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Bibliographic Details
Published in:Current oncology reports Vol. 22; no. 8; p. 81
Main Authors: Wondergem, Niels E., Nauta, Irene H., Muijlwijk, Tara, Leemans, C. René, van de Ven, Rieneke
Format: Journal Article
Language:English
Published: New York Springer US 01.08.2020
Springer Nature B.V
Subjects:
B-Lymphocytes - immunology
Cancer-Associated Fibroblasts - physiology
Dendritic Cells - immunology
Etiology
Head & neck cancer
Head and Neck Cancers (EY Hanna
Head and Neck Cancers (EY Hanna, Section Editor)
Humans
Immunotherapy
Killer Cells, Natural - immunology
Localization
Medicine
Medicine & Public Health
Neutrophils - immunology
Oncology
Section Editor
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck - immunology
T-Lymphocytes - immunology
Topical Collection on Head and Neck Cancers
Transcription
Tumor Microenvironment
Innate and adaptive immune system
HNSCC subsites
Head and neck squamous cell carcinoma
Tumor infiltrating lymphocytes
Prognosis
Tumor microenvironment
ISSN:1523-3790, 1534-6269, 1534-6269
Online Access:Get full text
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Summary:Purpose To understand why some patients respond to immunotherapy but many do not, a clear picture of the tumor microenvironment (TME) of head and neck squamous cell carcinoma (HNSCC) is key. Here we review the current understanding on the immune composition per HNSCC subsite, the importance of the tumor’s etiology and the prognostic power of specific immune cells. Recent Findings Large cohort data are mostly based on deconvolution of transcriptional databases. Studies focusing on infiltrate localization often entail small cohorts, a mixture of HNSCC subsites, or focus on a single immune marker rather than the interaction between cells within the TME. Summary Conclusions on the prognostic impact of specific immune cells in HNSCC are hampered by the use of heterogeneous or small cohorts. To move forward, the field should focus on deciphering the immune composition per HNSCC subsite, in powered cohorts and considering the molecular diversity in this disease.
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ISSN:1523-3790
1534-6269
1534-6269
DOI:10.1007/s11912-020-00938-3