USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy

Anti-PD-1/PD-L1 immunotherapy has achieved impressive therapeutic outcomes in patients with multiple cancer types. However, the underlined molecular mechanism(s) for moderate response rate (15–25%) or resistance to PD-1/PD-L1 blockade remains not completely understood. Here, we report that inhibitin...

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Veröffentlicht in:	Nature communications Jg. 13; H. 1; S. 1700 - 17
Hauptverfasser:	Xiong, Wenjun, Gao, Xueliang, Zhang, Tiantian, Jiang, Baishan, Hu, Ming-Ming, Bu, Xia, Gao, Yang, Zhang, Lin-Zhou, Xiao, Bo-Lin, He, Chuan, Sun, Yishuang, Li, Haiou, Shi, Jie, Xiao, Xiangling, Xiang, Bolin, Xie, Conghua, Chen, Gang, Zhang, Haojian, Wei, Wenyi, Freeman, Gordon J., Shu, Hong-Bing, Wang, Haizhen, Zhang, Jinfang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 31.03.2022 Nature Publishing Group Nature Portfolio
Schlagworte:	13/31 38/88 45/90 45/91 631/337/458/582 631/67/327 64/60 Animal models Animals Anticancer properties CD8 antigen CD8-Positive T-Lymphocytes Cell Line, Tumor Endopeptidases - genetics Endosomal Sorting Complexes Required for Transport - genetics Humanities and Social Sciences Humans Immune response Immune system Immunotherapy Inflammation Inhibitors Innate immunity L1 protein Lymphocytes Lymphocytes T Major histocompatibility complex Mice multidisciplinary Neoplasms - drug therapy Neoplasms - genetics NF-κB protein PD-1 protein PD-L1 protein Programmed Cell Death 1 Receptor - antagonists & inhibitors Proteins Regulatory mechanisms (biology) Science Science (multidisciplinary) Signaling TRAF6 protein Tumor Microenvironment Tumors Ubiquitin Thiolesterase - antagonists & inhibitors Ubiquitin Thiolesterase - genetics Ubiquitination
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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