Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure

Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvest 1352 healthy and failing human hearts directly from transplant center operating rooms, and obtain genome-wide genotyping and gene expression m...

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Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; pp. 2760 - 14
Main Authors:	Cordero, Pablo, Parikh, Victoria N., Chin, Elizabeth T., Erbilgin, Ayca, Gloudemans, Michael J., Shang, Ching, Huang, Yong, Chang, Alex C., Smith, Kevin S., Dewey, Frederick, Zaleta, Kathia, Morley, Michael, Brandimarto, Jeff, Glazer, Nicole, Waggott, Daryl, Pavlovic, Aleksandra, Zhao, Mingming, Moravec, Christine S., Tang, W. H. Wilson, Skreen, Jamie, Malloy, Christine, Hannenhalli, Sridhar, Li, Hongzhe, Ritter, Scott, Li, Mingyao, Bernstein, Daniel, Connolly, Andrew, Hakonarson, Hakon, Lusis, Aldons J., Margulies, Kenneth B., Depaoli-Roach, Anna A., Montgomery, Stephen B., Wheeler, Matthew T., Cappola, Thomas, Ashley, Euan A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 24.06.2019 Nature Publishing Group Nature Portfolio
Subjects:	45/23 45/91 631/114/2391 631/208/199 692/4019/592/2727 692/4019/592/75/230 Animals Benzeneacetamides Cardiomyocytes Cells, Cultured Congestive heart failure Datasets as Topic Disease Models, Animal Female Gene expression Gene Expression Profiling - methods Gene Expression Regulation Gene Knockdown Techniques Gene mapping Gene Regulatory Networks - genetics Gene sequencing Genome-Wide Association Study Genomes Genotyping Heart Heart failure Heart Failure - etiology Heart Failure - genetics Heart Failure - metabolism Heart Failure - pathology Humanities and Social Sciences Humans Male Metabolic Networks and Pathways - genetics Metabolic pathways Metabolism Mice Mice, Knockout Middle Aged multidisciplinary Myocytes, Cardiac - pathology Phosphoprotein Phosphatases - genetics Phosphoprotein Phosphatases - metabolism Pressure Primary Cell Culture Pyridines Quantitative trait loci Quantitative Trait Loci - genetics Rats Rats, Sprague-Dawley Regulators Rewiring Ribonucleic acid RNA Science Science (multidisciplinary) Sequence Analysis, RNA - methods
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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