Telomere length in white blood cell DNA and lung cancer: a pooled analysis of three prospective cohorts

We investigated the relationship between telomere length and lung cancer in a pooled analysis from three prospective cohort studies: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, conducted among men and women in the United States, and previously published data from the Al...

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Vydáno v:Cancer research (Chicago, Ill.) Ročník 74; číslo 15; s. 4090
Hlavní autoři: Seow, Wei Jie, Cawthon, Richard M, Purdue, Mark P, Hu, Wei, Gao, Yu-Tang, Huang, Wen-Yi, Weinstein, Stephanie J, Ji, Bu-Tian, Virtamo, Jarmo, Hosgood, 3rd, H Dean, Bassig, Bryan A, Shu, Xiao-Ou, Cai, Qiuyin, Xiang, Yong-Bing, Min, Shen, Chow, Wong-Ho, Berndt, Sonja I, Kim, Christopher, Lim, Unhee, Albanes, Demetrius, Caporaso, Neil E, Chanock, Stephen, Zheng, Wei, Rothman, Nathaniel, Lan, Qing
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.08.2014
Témata:
Case-Control Studies
Cohort Studies
DNA - blood
DNA - genetics
DNA, Neoplasm - blood
DNA, Neoplasm - genetics
Female
Humans
Leukocytes - metabolism
Leukocytes - ultrastructure
Lung Neoplasms - blood
Lung Neoplasms - genetics
Male
Middle Aged
Prospective Studies
Risk Factors
Telomere - genetics
ISSN:1538-7445, 1538-7445
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Shrnutí:We investigated the relationship between telomere length and lung cancer in a pooled analysis from three prospective cohort studies: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, conducted among men and women in the United States, and previously published data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Trial conducted among male smokers in Finland, and the Shanghai Women's Health Study (SWHS), which is comprised primarily of never-smokers. The pooled population included 847 cases and 847 controls matched by study, age, and sex. Leukocyte telomere length was measured by a monochrome multiplex qPCR assay. We used conditional logistic regression models to calculate ORs and their 95% confidence intervals (CI) for the association between telomere length and lung cancer risk, adjusted for age and pack-years of smoking. Longer telomere length was associated with increased lung cancer risk in the pooled analysis [OR (95% CI) by quartile: 1.00; 1.24 (0.90-1.71); 1.27 (0.91-1.78); and 1.86 (1.33-2.62); P trend = 0.000022]. Findings were consistent across the three cohorts and strongest for subjects with very long telomere length, i.e., lung cancer risks for telomere length [OR (95% CI)] in the upper half of the fourth quartile were 2.41 (1.28-4.52), 2.16 (1.11-4.23), and 3.02(1.39-6.58) for the PLCO trial, the ATBC trial, and the SWHS, respectively. In addition, the association persisted among cases diagnosed more than 6 years after blood collection and was particularly evident for female adenocarcinoma cases. Telomere length in white blood cell DNA may be a biomarker of future increased risk of lung cancer in diverse populations.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1538-7445
1538-7445
DOI:10.1158/0008-5472.CAN-14-0459