Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure

Cells are exposed to oxidative stress and reactive metabolites every day. The Nrf2 signaling pathway responds to oxidative stress by upregulation of antioxidants like glutathione (GSH) to compensate the stress insult and re-establish homeostasis. Although mechanisms describing the interaction betwee...

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Bibliographic Details
Published in:	Scientific reports Vol. 12; no. 1; pp. 7336 - 10
Main Authors:	Hiemstra, Steven, Fehling-Kaschek, Mirjam, Kuijper, Isoude A., Bischoff, Luc J. M., Wijaya, Lukas S., Rosenblatt, Marcus, Esselink, Jeroen, van Egmond, Allard, Mos, Jornt, Beltman, Joost B., Timmer, Jens, van de Water, Bob, Kaschek, Daniel
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05.05.2022 Nature Publishing Group Nature Portfolio
Subjects:	631/553/1833 631/553/2695 639/705/794 Antioxidants Cell activation Confocal microscopy Diclofenac Diethyl maleate Glutathione Glutathione - metabolism Green fluorescent protein Hep G2 Cells Hepatocytes Hepatocytes - metabolism Homeostasis Humanities and Social Sciences Humans Kelch-Like ECH-Associated Protein 1 - metabolism Liver Liver - metabolism Mathematical models Metabolites multidisciplinary NF-E2-Related Factor 2 - metabolism Omeprazole Ordinary differential equations Oxidative Stress Science Science (multidisciplinary) Signal transduction siRNA Toxicants
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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