Biospecimens and Molecular and Cellular Biomarkers in Aneurysmal Subarachnoid Hemorrhage Studies: Common Data Elements and Standard Reporting Recommendations

Introduction Development of clinical biomarkers to guide therapy is an important unmet need in aneurysmal subarachnoid hemorrhage (SAH). A wide spectrum of plausible biomarkers has been reported for SAH, but none have been validated due to significant variabilities in study design, methodology, labo...

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Veröffentlicht in:	Neurocritical care Jg. 30; H. Suppl 1; S. 46 - 59
Hauptverfasser:	Chou, Sherry H.-Y., Macdonald, R. Loch, Keller, Emanuela
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Springer US 01.06.2019 Springer Nature B.V
Schlagworte:	Aneurysm, Ruptured - complications Aneurysm, Ruptured - metabolism Aneurysms Biomarkers Biomarkers - metabolism Biomedical Research Brain Ischemia - etiology Brain Ischemia - metabolism Catheters Common Data Elements Critical Care Medicine Disease Experimental methods Humans Intensive Internal Medicine Intracranial Aneurysm - metabolism Medicine Medicine & Public Health Microdialysis Mortality National Institute of Neurological Disorders and Stroke (U.S.) National Library of Medicine (U.S.) Nervous system Neurology Oncology Prognosis Special Article Specimen Handling Stroke Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - metabolism United States Validity Vasospasm, Intracranial - etiology Vasospasm, Intracranial - metabolism United States Biospecimens Plasma-type gelsolin Cardiac troponin I B-type natriuretic peptide, common data elements Standard operating procedure Subarachnoid hemorrhage Apolipoprotein E Biomarkers Cerebrospinal fluid S100β Tumor necrosis factor alpha, interleukin-6, metalloproteinase-9
ISSN:	1541-6933, 1556-0961, 1556-0961
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Zusammenfassung:	Introduction Development of clinical biomarkers to guide therapy is an important unmet need in aneurysmal subarachnoid hemorrhage (SAH). A wide spectrum of plausible biomarkers has been reported for SAH, but none have been validated due to significant variabilities in study design, methodology, laboratory techniques, and outcome endpoints. Methods A systematic review of SAH biomarkers was performed per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The panel’s recommendations focused on harmonization of (1) target cellular and molecular biomarkers for future investigation in SAH, (2) standardization of best-practice procedures in biospecimen and biomarker studies, and (3) experimental method reporting requirements to facilitate meta-analyses and future validation of putative biomarkers. Results No cellular or molecular biomarker has been validated for inclusion as “core” recommendation. Fifty-four studies met inclusion criteria and generated 33 supplemental and emerging biomarker targets. Core recommendations include best-practice protocols for biospecimen collection and handling as well as standardized reporting guidelines to capture the heterogeneity and variabilities in experimental methodologies and biomarker analyses platforms. Conclusion Significant variabilities in study design, methodology, laboratory techniques, and outcome endpoints exist in SAH biomarker studies and present significant barriers toward validation and translation of putative biomarkers to clinical use. Adaptation of common data elements, recommended biospecimen protocols, and reporting guidelines will reduce heterogeneity and facilitate future meta-analyses and development of validated clinical biomarkers in SAH.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-News-1 ObjectType-Feature-3 content type line 23 Authors’ Contributions SHYC, RLM., and EK were involved in protocol development and wrote and edited the manuscript. The corresponding author confirms that authorship requirements have been met, that the final manuscript was approved by ALL authors, and that this manuscript has not been published elsewhere and is not under consideration by another journal. The UIA and SAH CDEs project adhered to ethical guidelines.
ISSN:	1541-6933 1556-0961 1556-0961
DOI:	10.1007/s12028-019-00725-4