Single-cell epigenomics reveals mechanisms of human cortical development

During mammalian development, differences in chromatin state coincide with cellular differentiation and reflect changes in the gene regulatory landscape 1 . In the developing brain, cell fate specification and topographic identity are important for defining cell identity 2 and confer selective vulne...

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Veröffentlicht in:	Nature (London) Jg. 598; H. 7879; S. 205 - 213
Hauptverfasser:	Ziffra, Ryan S., Kim, Chang N., Ross, Jayden M., Wilfert, Amy, Turner, Tychele N., Haeussler, Maximilian, Casella, Alex M., Przytycki, Pawel F., Keough, Kathleen C., Shin, David, Bogdanoff, Derek, Kreimer, Anat, Pollard, Katherine S., Ament, Seth A., Eichler, Evan E., Ahituv, Nadav, Nowakowski, Tomasz J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 07.10.2021 Nature Publishing Group
Schlagworte:	13/51 38/35 45/47 45/91 631/136/368/2430 631/378/2571/2575 96/100 Accessibility Atlases as Topic Binding sites Brain Brain - cytology Brain - growth & development Brain - metabolism Cell fate Cells (biology) Cerebral cortex Chromatin Chromatin - chemistry Chromatin - genetics Chromatin - metabolism Datasets Differentiation (biology) Disease Susceptibility Enhancer Elements, Genetic Epigenomics Forebrain Gene expression Humanities and Social Sciences Humans multidisciplinary Neural stem cells Neurodevelopmental disorders Neurogenesis Neurons - cytology Neurons - metabolism Organoids Organoids - cytology Prefrontal cortex Progenitor cells Regulatory sequences Retinoic acid Science Science (multidisciplinary) Single-Cell Analysis Specifications Transcription factors Transposase Tretinoin - metabolism
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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