Hypoxia-induced SETX links replication stress with the unfolded protein response

Tumour hypoxia is associated with poor patient prognosis and therapy resistance. A unique transcriptional response is initiated by hypoxia which includes the rapid activation of numerous transcription factors in a background of reduced global transcription. Here, we show that the biological response...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 3686 - 14
Main Authors:	Ramachandran, Shaliny, Ma, Tiffany S., Griffin, Jon, Ng, Natalie, Foskolou, Iosifina P., Hwang, Ming-Shih, Victori, Pedro, Cheng, Wei-Chen, Buffa, Francesca M., Leszczynska, Katarzyna B., El-Khamisy, Sherif F., Gromak, Natalia, Hammond, Ester M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17.06.2021 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/51 49/109 49/88 49/90 49/91 631/337 631/67 631/80 82/29 82/80 96/63 Activating Transcription Factor 4 - genetics Activating Transcription Factor 4 - metabolism Cell Death - drug effects Cell Death - genetics Cell Hypoxia Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Chromatin Immunoprecipitation Damage accumulation Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA Damage - genetics DNA helicase DNA Helicases - genetics DNA Helicases - metabolism eIF-2 Kinase - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Humanities and Social Sciences Humans Hypoxia Mammalian cells multidisciplinary Multifunctional Enzymes - genetics Multifunctional Enzymes - metabolism Nucleic Acid Synthesis Inhibitors - pharmacology Oxygen - pharmacology Protein folding Proteins R-Loop Structures - drug effects R-Loop Structures - genetics R-loops Replication Ribonucleic acid RNA RNA helicase RNA Helicases - genetics RNA Helicases - metabolism RNA-Seq Science Science (multidisciplinary) Transcription activation Transcription factors Tumors Unfolded Protein Response - drug effects Unfolded Protein Response - genetics Up-Regulation Zinostatin - pharmacology
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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