Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo

Photoactivatable molecules enable ablation of malignant cells under the control of light, yet current agents can be ineffective at early stages of disease when target cells are similar to healthy surrounding tissues. In this work, we describe a chemical platform based on amino-substituted benzoselen...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 2369 - 12
Main Authors:	Benson, Sam, de Moliner, Fabio, Fernandez, Antonio, Kuru, Erkin, Asiimwe, Nicholas L., Lee, Jun-Seok, Hamilton, Lloyd, Sieger, Dirk, Bravo, Isabel R., Elliot, Abigail M., Feng, Yi, Vendrell, Marc
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 22.04.2021 Nature Publishing Group Nature Portfolio
Subjects:	14 14/10 14/34 14/63 631/92/96 639/638/439/944 639/638/92 Ablation Animals Bacterial diseases Bacterial Infections - drug therapy Biocompatibility Biological activity Coculture Techniques Fluorescent Dyes - administration & dosage Fluorescent Dyes - adverse effects Fluorescent Dyes - chemistry Fluorescent Dyes - radiation effects Glioblastoma - drug therapy Glioblastoma - pathology Humanities and Social Sciences Humans Intravital Microscopy Light Metabolism Metabolites Microbial Sensitivity Tests Microscopy, Confocal Microscopy, Fluorescence multidisciplinary Organoselenium Compounds - administration & dosage Organoselenium Compounds - adverse effects Organoselenium Compounds - chemistry Organoselenium Compounds - radiation effects Photochemotherapy - methods Photodynamic therapy Photosensitivity Science Science (multidisciplinary) Side effects Spheroids, Cellular Warheads Xenograft Model Antitumor Assays Zebrafish
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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