Venous identity requires BMP signalling through ALK3

Venous endothelial cells are molecularly and functionally distinct from their arterial counterparts. Although veins are often considered the default endothelial state, genetic manipulations can modulate both acquisition and loss of venous fate, suggesting that venous identity is the result of active...

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Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; pp. 453 - 18
Main Authors:	Neal, Alice, Nornes, Svanhild, Payne, Sophie, Wallace, Marsha D., Fritzsche, Martin, Louphrasitthiphol, Pakavarin, Wilkinson, Robert N., Chouliaras, Kira M., Liu, Ke, Plant, Karen, Sholapurkar, Radhika, Ratnayaka, Indrika, Herzog, Wiebke, Bond, Gareth, Chico, Tim, Bou-Gharios, George, De Val, Sarah
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28.01.2019 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/51 38/15 38/77 45/15 631/136/16/1986 631/136/2060/16 631/337/572/2102 64/116 64/60 Animals Animals, Genetically Modified Binding Bone Morphogenetic Protein Receptors, Type I - genetics Bone Morphogenetic Protein Receptors, Type I - metabolism Bone morphogenetic proteins Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Cell signaling Coronary vessels Embryos Endothelial cells Endothelial Cells - metabolism Endothelium Gene expression Gene Expression Regulation, Developmental Gene regulation Humanities and Social Sciences Kinases Mice, Knockout Mice, Transgenic Morphology multidisciplinary Proteins Receptor, EphB4 - genetics Receptor, EphB4 - metabolism Science Science (multidisciplinary) Signal Transduction - genetics Signaling Smad protein Smad1 Protein - genetics Smad1 Protein - metabolism Smad5 protein Smad5 Protein - genetics Smad5 Protein - metabolism Transcription Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Vascular endothelial growth factor Veins Veins & arteries Veins - embryology Veins - metabolism Zebrafish Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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