Improved cytocompatibility and antibacterial properties of zinc-substituted brushite bone cement based on β-tricalcium phosphate

For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (...

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Published in:	Journal of materials science. Materials in medicine Vol. 32; no. 9; pp. 99 - 12
Main Authors:	Fadeeva, Inna V., Goldberg, Margarita A., Preobrazhensky, Ilya I., Mamin, Georgy V., Davidova, Galina A., Agafonova, Nadezhda V., Fosca, Marco, Russo, Fabrizio, Barinov, Sergey M., Cavalu, Simona, Rau, Julietta V.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.09.2021 Springer Nature B.V Springer
Subjects:	Animals Anti-Bacterial Agents - pharmacology Antibacterial activity Biocompatibility Biocompatibility Studies Biodegradable materials Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Bone Cements Bone implants Bone Substitutes Bones Calcium phosphates Calcium Phosphates - chemistry Cell Survival Cell viability Cement Ceramics Chemistry and Materials Science Coliforms Composites Compressive Strength Crystal lattices Cytotoxicity Durapatite E coli Electron Spin Resonance Spectroscopy Enterococcus faecium Escherichia coli Glass Growth factors Hydrogen-Ion Concentration Hydroxyapatite Infections Ions Materials Science Materials Testing Medicine Mice Microbial Sensitivity Tests Morphology Natural Materials Orthopedics Osteoconduction Osteogenesis Osteoporosis Pharmacy Phase composition Polymer Sciences Powders Pseudomonas aeruginosa Regenerative Medicine/Tissue Engineering Spectroscopy, Fourier Transform Infrared Substitutes Surfaces and Interfaces Surgery Thin Films Toxicity Transplants & implants Trauma Tricalcium phosphate X-Ray Diffraction Zinc Zinc - chemistry
ISSN:	0957-4530, 1573-4838, 1573-4838
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Abstract	For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCP were prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, and compressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture of brushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli , and Pseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblast NCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn 2+ ions was 10% higher compared to the β-TCP cement without zinc. The developed cements are perspective for applications in orthopedics and traumatology.
AbstractList	For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCP were prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, and compressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture of brushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli , and Pseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblast NCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn 2+ ions was 10% higher compared to the β-TCP cement without zinc. The developed cements are perspective for applications in orthopedics and traumatology. Abstract For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCP were prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, and compressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture of brushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblast NCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn2+ ions was 10% higher compared to the β-TCP cement without zinc. The developed cements are perspective for applications in orthopedics and traumatology. For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCP were prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, and compressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture of brushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblast NCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn2+ ions was 10% higher compared to the β-TCP cement without zinc. The developed cements are perspective for applications in orthopedics and traumatology. For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCP were prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, and compressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture of brushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblast NCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn ions was 10% higher compared to the β-TCP cement without zinc. The developed cements are perspective for applications in orthopedics and traumatology. For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCP were prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, and compressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture of brushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblast NCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn2+ ions was 10% higher compared to the β-TCP cement without zinc. The developed cements are perspective for applications in orthopedics and traumatology.For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCP were prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, and compressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture of brushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblast NCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn2+ ions was 10% higher compared to the β-TCP cement without zinc. The developed cements are perspective for applications in orthopedics and traumatology.
ArticleNumber	99
Author	Mamin, Georgy V. Goldberg, Margarita A. Russo, Fabrizio Cavalu, Simona Fosca, Marco Fadeeva, Inna V. Davidova, Galina A. Rau, Julietta V. Barinov, Sergey M. Preobrazhensky, Ilya I. Agafonova, Nadezhda V.
Author_xml	– sequence: 1 givenname: Inna V. surname: Fadeeva fullname: Fadeeva, Inna V. organization: A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences – sequence: 2 givenname: Margarita A. surname: Goldberg fullname: Goldberg, Margarita A. organization: A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences – sequence: 3 givenname: Ilya I. surname: Preobrazhensky fullname: Preobrazhensky, Ilya I. organization: Department of Materials Science, M.V. Lomonosov Moscow State University – sequence: 4 givenname: Georgy V. surname: Mamin fullname: Mamin, Georgy V. organization: Kazan Federal University – sequence: 5 givenname: Galina A. surname: Davidova fullname: Davidova, Galina A. organization: Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences – sequence: 6 givenname: Nadezhda V. surname: Agafonova fullname: Agafonova, Nadezhda V. organization: G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences” – sequence: 7 givenname: Marco surname: Fosca fullname: Fosca, Marco organization: Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR) – sequence: 8 givenname: Fabrizio surname: Russo fullname: Russo, Fabrizio organization: Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University – sequence: 9 givenname: Sergey M. surname: Barinov fullname: Barinov, Sergey M. organization: A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences – sequence: 10 givenname: Simona surname: Cavalu fullname: Cavalu, Simona organization: Faculty of Medicine and Pharmacy, University of Oradea – sequence: 11 givenname: Julietta V. orcidid: 0000-0002-7953-1853 surname: Rau fullname: Rau, Julietta V. email: giulietta.rau@ism.cnr.it organization: Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Department of Analytical, Physical and Colloid Chemistry, Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/34406523$$D View this record in MEDLINE/PubMed
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Copyright	The Author(s) 2021 2021. The Author(s). Copyright Springer Nature B.V. Sep 2021
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OpenAccessLink	https://link.springer.com/10.1007/s10856-021-06575-x
PMID	34406523
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PublicationCentury	2000
PublicationDate	2021-09-01
PublicationDateYYYYMMDD	2021-09-01
PublicationDate_xml	– month: 09 year: 2021 text: 2021-09-01 day: 01
PublicationDecade	2020
PublicationPlace	New York
PublicationPlace_xml	– name: New York – name: United States – name: London
PublicationTitle	Journal of materials science. Materials in medicine
PublicationTitleAbbrev	J Mater Sci: Mater Med
PublicationTitleAlternate	J Mater Sci Mater Med
PublicationYear	2021
Publisher	Springer US Springer Nature B.V Springer
Publisher_xml	– name: Springer US – name: Springer Nature B.V – name: Springer
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Snippet	For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new... Abstract For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new...
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SubjectTerms	Animals Anti-Bacterial Agents - pharmacology Antibacterial activity Biocompatibility Biocompatibility Studies Biodegradable materials Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Bone Cements Bone implants Bone Substitutes Bones Calcium phosphates Calcium Phosphates - chemistry Cell Survival Cell viability Cement Ceramics Chemistry and Materials Science Coliforms Composites Compressive Strength Crystal lattices Cytotoxicity Durapatite E coli Electron Spin Resonance Spectroscopy Enterococcus faecium Escherichia coli Glass Growth factors Hydrogen-Ion Concentration Hydroxyapatite Infections Ions Materials Science Materials Testing Medicine Mice Microbial Sensitivity Tests Morphology Natural Materials Orthopedics Osteoconduction Osteogenesis Osteoporosis Pharmacy Phase composition Polymer Sciences Powders Pseudomonas aeruginosa Regenerative Medicine/Tissue Engineering Spectroscopy, Fourier Transform Infrared Substitutes Surfaces and Interfaces Surgery Thin Films Toxicity Transplants & implants Trauma Tricalcium phosphate X-Ray Diffraction Zinc Zinc - chemistry
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Title	Improved cytocompatibility and antibacterial properties of zinc-substituted brushite bone cement based on β-tricalcium phosphate
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