Improved cytocompatibility and antibacterial properties of zinc-substituted brushite bone cement based on β-tricalcium phosphate

For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (...

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Bibliographic Details
Published in:	Journal of materials science. Materials in medicine Vol. 32; no. 9; pp. 99 - 12
Main Authors:	Fadeeva, Inna V., Goldberg, Margarita A., Preobrazhensky, Ilya I., Mamin, Georgy V., Davidova, Galina A., Agafonova, Nadezhda V., Fosca, Marco, Russo, Fabrizio, Barinov, Sergey M., Cavalu, Simona, Rau, Julietta V.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.09.2021 Springer Nature B.V Springer
Subjects:	Animals Anti-Bacterial Agents - pharmacology Antibacterial activity Biocompatibility Biocompatibility Studies Biodegradable materials Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Bone Cements Bone implants Bone Substitutes Bones Calcium phosphates Calcium Phosphates - chemistry Cell Survival Cell viability Cement Ceramics Chemistry and Materials Science Coliforms Composites Compressive Strength Crystal lattices Cytotoxicity Durapatite E coli Electron Spin Resonance Spectroscopy Enterococcus faecium Escherichia coli Glass Growth factors Hydrogen-Ion Concentration Hydroxyapatite Infections Ions Materials Science Materials Testing Medicine Mice Microbial Sensitivity Tests Morphology Natural Materials Orthopedics Osteoconduction Osteogenesis Osteoporosis Pharmacy Phase composition Polymer Sciences Powders Pseudomonas aeruginosa Regenerative Medicine/Tissue Engineering Spectroscopy, Fourier Transform Infrared Substitutes Surfaces and Interfaces Surgery Thin Films Toxicity Transplants & implants Trauma Tricalcium phosphate X-Ray Diffraction Zinc Zinc - chemistry
ISSN:	0957-4530, 1573-4838, 1573-4838
Online Access:	Get full text
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Summary:	For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCP were prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, and compressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture of brushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli , and Pseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblast NCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn 2+ ions was 10% higher compared to the β-TCP cement without zinc. The developed cements are perspective for applications in orthopedics and traumatology.
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ISSN:	0957-4530 1573-4838 1573-4838
DOI:	10.1007/s10856-021-06575-x