Aggregation-induced emission luminogens for image-guided surgery in non-human primates

During the past two decades, aggregation-induced emission luminogens (AIEgens) have been intensively exploited for biological and biomedical applications. Although a series of investigations have been performed in non-primate animal models, there is few pilot studies in non-human primate animal mode...

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Vydáno v:Nature communications Ročník 12; číslo 1; s. 6485 - 13
Hlavní autoři: Zhong, Danni, Chen, Weiyu, Xia, Zhiming, Hu, Rong, Qi, Yuchen, Zhou, Bo, Li, Wanlin, He, Jian, Wang, Zhiming, Zhao, Zujin, Ding, Dan, Tian, Mei, Tang, Ben Zhong, Zhou, Min
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 10.11.2021
Nature Publishing Group
Nature Portfolio
Témata:
14
631/67/2321
64/60
64/86
692/308/575
692/4028/546
96/34
Agglomeration
Animal models
Animals
Biomedical materials
Emissions
Fluorescence
Humanities and Social Sciences
Imaging
Lymph nodes
Macaca mulatta
Metastases
Monkeys & apes
multidisciplinary
Primates
Rabbits
Science
Science (multidisciplinary)
Sentinel Lymph Node - diagnostic imaging
Surgery
Surgery, Computer-Assisted - methods
Translation
Tumors
ISSN:2041-1723, 2041-1723
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Shrnutí:During the past two decades, aggregation-induced emission luminogens (AIEgens) have been intensively exploited for biological and biomedical applications. Although a series of investigations have been performed in non-primate animal models, there is few pilot studies in non-human primate animal models, strongly hindering the clinical translation of AIE luminogens (AIEgens). Herein, we present a systemic and multifaceted demonstration of an optical imaging-guided surgical operation via AIEgens from small animals (e.g., mice and rabbits) to rhesus macaque, the typical non-human primate animal model. Specifically, the folic conjugated-AIE luminogen (folic-AIEgen) generates strong and stable fluorescence for the detection and surgical excision of sentinel lymph nodes (SLNs). Moreover, with the superior tumor/normal tissue ratio and rapid tumor accumulation, folic-AIEgen successfully images and guides the precise resection of invisible cancerous metastases. Taken together, the presented strategies of folic-AIEgen based fluorescence intraoperative imaging and visualization-guided surgery show potential for clinical applications. Most applications of aggregation-induced emission luminogens (AIEgens) have been limited in small animal models. Here, the authors show the versatility of AIEgens-based imaging-guided surgical operation from small animals to rhesus macaque, in support of the clinical translation of AIEgens.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-021-26417-2