High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

Senescence is a proliferation arrest that can result from a variety of stresses. Cancer cells can also undergo senescence, but the stresses that provoke cancer cells to undergo senescence are unclear. Here, we use both functional genetic and compound screens in cancer cells harboring a reporter that...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 21; H. 3; S. 773 - 783
Hauptverfasser:	Wang, Liqin, Leite de Oliveira, Rodrigo, Wang, Cun, Fernandes Neto, João M., Mainardi, Sara, Evers, Bastiaan, Lieftink, Cor, Morris, Ben, Jochems, Fleur, Willemsen, Lisa, Beijersbergen, Roderick L., Bernards, René
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 17.10.2017 Elsevier
Schlagworte:	aurora kinase Aurora Kinases - antagonists & inhibitors Aurora Kinases - metabolism Cell Line, Tumor Cellular Senescence - drug effects Cellular Senescence - genetics compound screen CRISPR-Cas Systems - genetics Down-Regulation - genetics Gene Knockout Techniques Genes, Reporter genetic screens Genetic Testing Green Fluorescent Proteins - metabolism High-Throughput Screening Assays Humans Melanoma - genetics Melanoma - pathology miR146 Neoplasms - genetics Neoplasms - pathology Oncogenes Protein Kinase Inhibitors - pharmacology Receptor, Epidermal Growth Factor - metabolism senescence senolysis SMARCB1 Protein - genetics SOXE Transcription Factors - genetics SOXE Transcription Factors - metabolism SWI/SNF senescence miR146 SWI/SNF aurora kinase genetic screens compound screen senolysis
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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