Debate: Are cluster headache and migraine distinct headache disorders?

Cluster headache and migraine are regarded as distinct primary headaches. While cluster headache and migraine differ in multiple aspects such as gender-related and headache specific features (e.g., attack duration and frequency), both show clinical similarities in trigger factors (e.g., alcohol) and...

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Bibliographic Details
Published in:Journal of headache and pain Vol. 23; no. 1; pp. 151 - 13
Main Authors: Al-Karagholi, Mohammad Al-Mahdi, Peng, Kuan-Po, Petersen, Anja Sofie, De Boer, Irene, Terwindt, Gisela M., Ashina, Messoud
Format: Journal Article
Language:English
Published: Milan Springer Milan 01.12.2022
Springer Nature B.V
BMC
Subjects:
Age
CGRP
Classification
Cluster Headache - diagnosis
Cranial autonomic symptoms
Debates on Migraine
Headache
Headache Disorders
Headaches
Humans
Internal Medicine
Medicine
Medicine & Public Health
Migraine
Migraine Disorders - complications
Migraine Disorders - diagnosis
Neurological disorders
Neurology
Nitric oxide
PACAP
Pain
Pain Medicine
Patients
Remission (Medicine)
Review
Trigeminovascular system
Tryptamines
Cranial autonomic symptoms
PACAP
CGRP
Nitric oxide
Trigeminovascular system
ISSN:1129-2369, 1129-2377, 1129-2377
Online Access:Get full text
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Summary:Cluster headache and migraine are regarded as distinct primary headaches. While cluster headache and migraine differ in multiple aspects such as gender-related and headache specific features (e.g., attack duration and frequency), both show clinical similarities in trigger factors (e.g., alcohol) and treatment response (e.g., triptans). Here, we review the similarities and differences in anatomy and pathophysiology that underlie cluster headache and migraine, discuss whether cluster headache and migraine should indeed be considered as two distinct primary headaches, and propose recommendations for future studies. Graphical Abstract Video recording of the debate held at the 1st International Conference on Advances in Migraine Sciences (ICAMS 2022, Copenhagen, Denmark) is available at https://www.youtube.com/watch?v=uUimmnDVTTE .
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ISSN:1129-2369
1129-2377
1129-2377
DOI:10.1186/s10194-022-01504-x