Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study

Purpose The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was developed to evaluate the brain’s glymphatic function or interstitial fluid dynamics. This study aimed to evaluate the reproducibility of the DTI-ALPS method and the effect of modifications in the imaging...

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Vydané v:Japanese journal of radiology Ročník 40; číslo 2; s. 147 - 158
Hlavní autori: Taoka, Toshiaki, Ito, Rintaro, Nakamichi, Rei, Kamagata, Koji, Sakai, Mayuko, Kawai, Hisashi, Nakane, Toshiki, Abe, Takashi, Ichikawa, Kazushige, Kikuta, Junko, Aoki, Shigeki, Naganawa, Shinji
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Singapore Springer Singapore 01.02.2022
Springer Nature B.V
Predmet:
Diffusion
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Extracellular Fluid
Fluid dynamics
Humans
Hydrodynamics
Image acquisition
Image analysis
Image processing
Image Processing, Computer-Assisted
Imaging
Mathematical analysis
Medicine
Medicine & Public Health
Neuroimaging
Nuclear Medicine
Original
Original Article
Placement
Radiology
Radiotherapy
Reproducibility
Reproducibility of Results
Scanners
Tensors
Three axis
Glymphatic system
Brain interstitial fluid dynamics
Reproducibility
Diffusion image
DTI-ALPS
ISSN:1867-1071, 1867-108X, 1867-108X
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Shrnutí:Purpose The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was developed to evaluate the brain’s glymphatic function or interstitial fluid dynamics. This study aimed to evaluate the reproducibility of the DTI-ALPS method and the effect of modifications in the imaging method and data evaluation. Materials and methods Seven healthy volunteers were enrolled in this study. Image acquisition was performed for this test–retest study using a fixed imaging sequence and modified imaging methods which included the placement of region of interest (ROI), imaging plane, head position, averaging, number of motion-proving gradients, echo time (TE), and a different scanner. The ALPS-index values were evaluated for the change of conditions listed above. Results This test–retest study by a fixed imaging sequence showed very high reproducibility (intraclass coefficient = 0.828) for the ALPS-index value. The bilateral ROI placement showed higher reproducibility. The number of averaging and the difference of the scanner did not influence the ALPS-index values. However, modification of the imaging plane and head position impaired reproducibility, and the number of motion-proving gradients affected the ALPS-index value. The ALPS-index values from 12-axis DTI and 3-axis diffusion-weighted image (DWI) showed good correlation ( r  = 0.86). Also, a shorter TE resulted in a larger value of the ALPS-index. Conclusion ALPS index was robust under the fixed imaging method even when different scanners were used. ALPS index was influenced by the imaging plane, the number of motion-proving gradient axes, and TE in the imaging sequence. These factors should be uniformed in the planning ALPS method studies. The possibility to develop a 3-axis DWI-ALPS method using three axes of the motion-proving gradient was also suggested.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1867-1071
1867-108X
1867-108X
DOI:10.1007/s11604-021-01187-5