Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

The sterol-regulatory element binding proteins (SREBP) are central transcriptional regulators of lipid metabolism. Using haploid genetic screens we identify the S REB P R egulat in g G ene ( SPRING/C12ORF49 ) as a determinant of the SREBP pathway. SPRING is a glycosylated Golgi-resident membrane pro...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 1128 - 14
Main Authors:	Loregger, Anke, Raaben, Matthijs, Nieuwenhuis, Joppe, Tan, Josephine M. E., Jae, Lucas T., van den Hengel, Lisa G., Hendrix, Sebastian, van den Berg, Marlene, Scheij, Saskia, Song, Ji-Ying, Huijbers, Ivo J., Kroese, Lona J., Ottenhoff, Roelof, van Weeghel, Michel, van de Sluis, Bart, Brummelkamp, Thijn, Zelcer, Noam
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28.02.2020 Nature Publishing Group Nature Portfolio
Subjects:	13 13/1 13/109 13/31 14/19 38 38/109 38/39 38/70 38/91 45/41 49/90 631/337/4041/3196 631/45/287 631/80/304 64/60 96/106 96/47 Ablation Animals Cell Line Cholesterol Cholesterol - metabolism Cleavage Clonal deletion Embryonic Development - genetics Embryos Endoplasmic Reticulum - metabolism Fatty acids Gene Expression Genetic screening Golgi Apparatus - metabolism Haploidy Hepatocytes Hepatocytes - metabolism Hepatoma Humanities and Social Sciences Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinases Lipid metabolism Lipid Metabolism - genetics Lipids Liver - metabolism Liver cancer Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane proteins Membrane Proteins - genetics Membrane Proteins - metabolism Metabolism Mice Mice, Inbred C57BL multidisciplinary Proteins Regulators Regulatory sequences Science Science (multidisciplinary) Signal Transduction Signaling Sterol Regulatory Element Binding Proteins - genetics Sterol Regulatory Element Binding Proteins - metabolism Sterol regulatory element-binding protein Sterols Tumor cell lines Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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