Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

The non-classical class Ib molecule human leukocyte antigen E (HLA-E) has limited polymorphism and can bind HLA class Ia leader peptides (VL9). HLA-E-VL9 complexes interact with the natural killer (NK) cell receptors NKG2A-C/CD94 and regulate NK cell-mediated cytotoxicity. Here we report the isolati...

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Bibliographic Details
Published in:	Communications biology Vol. 5; no. 1; pp. 271 - 17
Main Authors:	Li, Dapeng, Brackenridge, Simon, Walters, Lucy C., Swanson, Olivia, Harlos, Karl, Rozbesky, Daniel, Cain, Derek W., Wiehe, Kevin, Scearce, Richard M., Barr, Maggie, Mu, Zekun, Parks, Robert, Quastel, Max, Edwards, Robert J., Wang, Yunfei, Rountree, Wes, Saunders, Kevin O., Ferrari, Guido, Borrow, Persephone, Jones, E. Yvonne, Alam, S. Munir, Azoitei, Mihai L., Gillespie, Geraldine M., McMichael, Andrew J., Haynes, Barton F.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28.03.2022 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/109 13/31 14/28 14/34 14/63 38 38/77 42 631/250/1619/382 631/250/2152/2153/1291 631/535/1266 631/61/51/1568 64/60 82 82/80 82/83 Animals Antibodies Biology Biomedical and Life Sciences Cytomegalovirus Cytotoxicity Cytotoxicity, Immunologic Histocompatibility antigen HLA Histocompatibility Antigens Class I - genetics HLA Antigens HLA-E Antigens Humans Immunoglobulin G Immunoglobulin M Immunoglobulins - metabolism Killer Cells, Natural Life Sciences Lymphocytes B Mice Natural killer cells NKG2 antigen Peptides - metabolism Protein Sorting Signals
ISSN:	2399-3642, 2399-3642
Online Access:	Get full text
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