Quantifying the contribution of transcription factor activity, mutations and microRNAs to CD274 expression in cancer patients

Immune checkpoint inhibitors targeting the programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) axis have been remarkably successful in inducing tumor remissions in several human cancers, yet a substantial number of patients do not respond to treatment. Because this...

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Bibliographic Details
Published in:	Scientific reports Vol. 12; no. 1; pp. 4374 - 15
Main Authors:	Bruns, Imke B., Beltman, Joost B.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.03.2022 Nature Publishing Group Nature Portfolio
Subjects:	631/114 631/67 692/4028 692/53 Apoptosis B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Cell Cycle Proteins - genetics Cell death Gene expression Genomes Humanities and Social Sciences Humans Immune checkpoint inhibitors Interferon regulatory factor 1 MicroRNAs MicroRNAs - genetics miRNA multidisciplinary Mutation Neoplasms - genetics NF-κB protein Nuclear Proteins - genetics Patients PD-1 protein PD-L1 protein Regression analysis RNA, Messenger - genetics RNA, Messenger - metabolism Science Science (multidisciplinary) Stat1 protein Transcription factors Transcription Factors - genetics Tumors
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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