SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

Long-term antibody responses and neutralizing activities in response to SARS-CoV-2 infection are not yet clear. Here we quantify immunoglobulin M (IgM) and G (IgG) antibodies recognizing the SARS-CoV-2 receptor-binding domain (RBD) of the spike (S) or the nucleocapsid (N) protein, and neutralizing a...

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Vydáno v:	Nature communications Ročník 12; číslo 1; s. 1813 - 9
Hlavní autoři:	Wu, Jun, Liang, Boyun, Chen, Cunrong, Wang, Hua, Fang, Yaohui, Shen, Shu, Yang, Xiaoli, Wang, Baoju, Chen, Liangkai, Chen, Qi, Wu, Yang, Liu, Jia, Yang, Xuecheng, Li, Wei, Zhu, Bin, Zhou, Wenqing, Wang, Huan, Li, Sumeng, Lu, Sihong, Liu, Di, Li, Huadong, Krawczyk, Adalbert, Lu, Mengji, Yang, Dongliang, Deng, Fei, Dittmer, Ulf, Trilling, Mirko, Zheng, Xin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 22.03.2021 Nature Publishing Group Nature Portfolio
Témata:	13/1 631/250/2152/2153/1291 631/326/596/4130 692/699/255/2514 Adult Aged Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Binding Contraction Coronaviruses COVID-19 COVID-19 - immunology Female Humanities and Social Sciences Humans Humoral immunity Immune response Immune response (humoral) Immunity Immunity, Humoral - immunology Immunoglobulin G Immunoglobulin G - immunology Immunoglobulin M Immunoglobulin M - immunology Male Middle Aged multidisciplinary Neutralizing Nucleocapsids SARS-CoV-2 - immunology Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Spike Glycoprotein, Coronavirus Spikes Viral diseases
ISSN:	2041-1723, 2041-1723
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Shrnutí:	Long-term antibody responses and neutralizing activities in response to SARS-CoV-2 infection are not yet clear. Here we quantify immunoglobulin M (IgM) and G (IgG) antibodies recognizing the SARS-CoV-2 receptor-binding domain (RBD) of the spike (S) or the nucleocapsid (N) protein, and neutralizing antibodies during a period of 6 months from COVID-19 disease onset in 349 symptomatic COVID-19 patients who were among the first be infected world-wide. The positivity rate and magnitude of IgM-S and IgG-N responses increase rapidly. High levels of IgM-S/N and IgG-S/N at 2-3 weeks after disease onset are associated with virus control and IgG-S titers correlate closely with the capacity to neutralize SARS-CoV-2. Although specific IgM-S/N become undetectable 12 weeks after disease onset in most patients, IgG-S/N titers have an intermediate contraction phase, but stabilize at relatively high levels over the 6 month observation period. At late time points, the positivity rates for binding and neutralizing SARS-CoV-2-specific antibodies are still >70%. These data indicate sustained humoral immunity in recovered patients who had symptomatic COVID-19, suggesting prolonged immunity. A better understanding of longitudinal changes in antibody responses in COVID-19 patients is needed. Here the authors analyze anti-spike and anti-nucleocapsid antibody responses to Sars-CoV-2 over a course of 6 months in a large cohort of patients with COVID-19, showing that IgM is mostly not detectable after 3 months, whereas IgG responses contract, yet remain at high levels at 6 months.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-021-22034-1