Stable representation of a naturalistic movie emerges from episodic activity with gain variability

Visual cortical responses are known to be highly variable across trials within an experimental session. However, the long-term stability of visual cortical responses is poorly understood. Here using chronic imaging of V1 in mice we show that neural responses to repeated natural movie clips are unsta...

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Bibliographic Details
Published in:Nature communications Vol. 12; no. 1; pp. 5170 - 15
Main Authors: Xia, Ji, Marks, Tyler D., Goard, Michael J., Wessel, Ralf
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 27.08.2021
Nature Publishing Group
Nature Portfolio
Subjects:
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631/378/116/2394
631/378/116/2395
631/378/2613/1875
64/110
Animals
Dimensional stability
Female
Humanities and Social Sciences
Male
Mice
Mice, Transgenic
Motion Pictures
multidisciplinary
Neurons
Neurons - physiology
Photic Stimulation
Population
Representations
Science
Science (multidisciplinary)
Variability
Visual Cortex - physiology
Visual Perception
ISSN:2041-1723, 2041-1723
Online Access:Get full text
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Summary:Visual cortical responses are known to be highly variable across trials within an experimental session. However, the long-term stability of visual cortical responses is poorly understood. Here using chronic imaging of V1 in mice we show that neural responses to repeated natural movie clips are unstable across weeks. Individual neuronal responses consist of sparse episodic activity which are stable in time but unstable in gain across weeks. Further, we find that the individual episode, instead of neuron, serves as the basic unit of the week-to-week fluctuation. To investigate how population activity encodes the stimulus, we extract a stable one-dimensional representation of the time in the natural movie, using an unsupervised method. Most week-to-week fluctuation is perpendicular to the stimulus encoding direction, thus leaving the stimulus representation largely unaffected. We propose that precise episodic activity with coordinated gain changes are keys to maintain a stable stimulus representation in V1. Here the authors show that individual neural responses in mouse V1 to a repeated natural movie clip consist of episodic activity which is unstable in gain across weeks. Despite of the gain variability, time in the natural movie is stably represented by population activity in V1.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-021-25437-2