Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes

Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in n...

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Vydáno v:	Nature communications Ročník 10; číslo 1; s. 3503 - 12
Hlavní autoři:	Wang, Heming, Lane, Jacqueline M., Jones, Samuel E., Dashti, Hassan S., Ollila, Hanna M., Wood, Andrew R., van Hees, Vincent T., Brumpton, Ben, Winsvold, Bendik S., Kantojärvi, Katri, Palviainen, Teemu, Cade, Brian E., Sofer, Tamar, Song, Yanwei, Patel, Krunal, Anderson, Simon G., Bechtold, David A., Bowden, Jack, Emsley, Richard, Kyle, Simon D., Little, Max A., Loudon, Andrew S., Scheer, Frank A. J. L., Purcell, Shaun M., Richmond, Rebecca C., Spiegelhalder, Kai, Tyrrell, Jessica, Zhu, Xiaofeng, Hublin, Christer, Kaprio, Jaakko A., Kristiansson, Kati, Sulkava, Sonja, Paunio, Tiina, Hveem, Kristian, Nielsen, Jonas B., Willer, Cristen J., Zwart, John-Anker, Strand, Linn B., Frayling, Timothy M., Ray, David, Lawlor, Deborah A., Rutter, Martin K., Weedon, Michael N., Redline, Susan, Saxena, Richa
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 13.08.2019 Nature Publishing Group Nature Portfolio
Témata:	45/43 631/208/205/2138 631/378/1385/519 692/617/375/1816 Accelerometers Adult Age Factors Aged Aging Association analysis Brain Cardiovascular disease Cardiovascular diseases Cognitive ability Coronary artery disease Datasets as Topic Daytime Female Genetic Loci Genome-Wide Association Study Genomes Health risk assessment Heart diseases Humanities and Social Sciences Humans Insomnia Loci Male Mental disorders Middle Aged multidisciplinary Polymorphism, Single Nucleotide Polysomnography Restless legs syndrome Science Science (multidisciplinary) Self Report - statistics & numerical data Sex Factors Single-nucleotide polymorphism Sleep Sleep - genetics Sleep and wakefulness Sleep deprivation Sleep disorders Sleepiness Young Adult
ISSN:	2041-1723, 2041-1723
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