Preclinical development of a miR-132 inhibitor for heart failure treatment

Despite proven efficacy of pharmacotherapies targeting primarily global neurohormonal dysregulation, heart failure (HF) is a growing pandemic with increasing burden. Treatments mechanistically focusing at the cardiomyocyte level are lacking. MicroRNAs (miRNA) are transcriptional regulators and essen...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 633 - 10
Main Authors:	Foinquinos, Ariana, Batkai, Sandor, Genschel, Celina, Viereck, Janika, Rump, Steffen, Gyöngyösi, Mariann, Traxler, Denise, Riesenhuber, Martin, Spannbauer, Andreas, Lukovic, Dominika, Weber, Natalie, Zlabinger, Katrin, Hašimbegović, Ena, Winkler, Johannes, Fiedler, Jan, Dangwal, Seema, Fischer, Martin, de la Roche, Jeanne, Wojciechowski, Daniel, Kraft, Theresia, Garamvölgyi, Rita, Neitzel, Sonja, Chatterjee, Shambhabi, Yin, Xiaoke, Bär, Christian, Mayr, Manuel, Xiao, Ke, Thum, Thomas
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 31.01.2020 Nature Publishing Group Nature Portfolio
Subjects:	13/89 38/39 38/89 38/90 64/60 692/4019/592/1540 692/4019/592/75/230 Animal models Animals Antisense oligonucleotides Cardiomyocytes Chemical compounds Congestive heart failure Drug Evaluation, Preclinical Drug therapy Female Gene Expression Regulation Genetic Therapy - methods Heart failure Heart Failure - genetics Heart Failure - metabolism Heart Failure - therapy Humanities and Social Sciences Humans Inhibitors MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Mode of action multidisciplinary Myocytes, Cardiac - metabolism Nucleic acids Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - metabolism Oligonucleotides, Antisense - pharmacokinetics Pandemics Pharmacokinetics Pharmacology Regulators Safety Science Science (multidisciplinary) Swine Transcription
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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