A coordinated progression of progenitor cell states initiates urinary tract development

The kidney and upper urinary tract develop through reciprocal interactions between the ureteric bud and the surrounding mesenchyme. Ureteric bud branching forms the arborized collecting duct system of the kidney, while ureteric tips promote nephron formation from dedicated progenitor cells. While ne...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nature communications Ročník 12; číslo 1; s. 2627 - 16
Hlavní autoři: Sanchez-Ferras, Oraly, Pacis, Alain, Sotiropoulou, Maria, Zhang, Yuhong, Wang, Yu Chang, Bourgey, Mathieu, Bourque, Guillaume, Ragoussis, Jiannis, Bouchard, Maxime
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 11.05.2021
Nature Publishing Group
Nature Portfolio
Témata:
13/31
13/51
14/19
38/91
631/114
631/136/142
631/136/2060
631/80
Animals
AP-2 protein
Cell Differentiation - genetics
Cells (biology)
Clusters
Collecting duct
Developmental disabilities
Embryo, Mammalian
Embryos
Female
GATA-3 protein
GATA3 Transcription Factor - metabolism
Gene Expression Regulation, Developmental
Humanities and Social Sciences
Kidneys
Male
Mesenchyme
Mesoderm
Mice
Mice, Transgenic
Models, Animal
Morphogenesis
multidisciplinary
Nephrons - embryology
Organogenesis - genetics
Populations
Progenitor cells
Ribonucleic acid
RNA
RNA-Seq
Science
Science (multidisciplinary)
Single-Cell Analysis
Stem cells
Stem Cells - physiology
Tips
Transcription Factor AP-2 - metabolism
Transcription factors
Ureter
Urinary tract
Urogenital system
ISSN:2041-1723, 2041-1723
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract The kidney and upper urinary tract develop through reciprocal interactions between the ureteric bud and the surrounding mesenchyme. Ureteric bud branching forms the arborized collecting duct system of the kidney, while ureteric tips promote nephron formation from dedicated progenitor cells. While nephron progenitor cells are relatively well characterized, the origin of ureteric bud progenitors has received little attention so far. It is well established that the ureteric bud is induced from the nephric duct, an epithelial duct derived from the intermediate mesoderm of the embryo. However, the cell state transitions underlying the progression from intermediate mesoderm to nephric duct and ureteric bud remain unknown. Here we show that nephric duct morphogenesis results from the coordinated organization of four major progenitor cell populations. Using single cell RNA-seq and Cluster RNA-seq, we show that these progenitors emerge in time and space according to a stereotypical pattern. We identify the transcription factors Tfap2a/b and Gata3 as critical coordinators of this progenitor cell progression. This study provides a better understanding of the cellular origin of the renal collecting duct system and associated urinary tract developmental diseases, which may inform guided differentiation of functional kidney tissue. Nephric duct (ND)-derived ureteric buds (UB) form the kidney collecting duct system, while ureteric tips promote nephron formation. Here the authors use single-cell RNA-seq and introduce Cluster RNA-seq to identify four progenitor populations in developing ND/UB regulated by the transcription factors Tfap2a/b and Gata3.
AbstractList The kidney and upper urinary tract develop through reciprocal interactions between the ureteric bud and the surrounding mesenchyme. Ureteric bud branching forms the arborized collecting duct system of the kidney, while ureteric tips promote nephron formation from dedicated progenitor cells. While nephron progenitor cells are relatively well characterized, the origin of ureteric bud progenitors has received little attention so far. It is well established that the ureteric bud is induced from the nephric duct, an epithelial duct derived from the intermediate mesoderm of the embryo. However, the cell state transitions underlying the progression from intermediate mesoderm to nephric duct and ureteric bud remain unknown. Here we show that nephric duct morphogenesis results from the coordinated organization of four major progenitor cell populations. Using single cell RNA-seq and Cluster RNA-seq, we show that these progenitors emerge in time and space according to a stereotypical pattern. We identify the transcription factors Tfap2a/b and Gata3 as critical coordinators of this progenitor cell progression. This study provides a better understanding of the cellular origin of the renal collecting duct system and associated urinary tract developmental diseases, which may inform guided differentiation of functional kidney tissue.
The kidney and upper urinary tract develop through reciprocal interactions between the ureteric bud and the surrounding mesenchyme. Ureteric bud branching forms the arborized collecting duct system of the kidney, while ureteric tips promote nephron formation from dedicated progenitor cells. While nephron progenitor cells are relatively well characterized, the origin of ureteric bud progenitors has received little attention so far. It is well established that the ureteric bud is induced from the nephric duct, an epithelial duct derived from the intermediate mesoderm of the embryo. However, the cell state transitions underlying the progression from intermediate mesoderm to nephric duct and ureteric bud remain unknown. Here we show that nephric duct morphogenesis results from the coordinated organization of four major progenitor cell populations. Using single cell RNA-seq and Cluster RNA-seq, we show that these progenitors emerge in time and space according to a stereotypical pattern. We identify the transcription factors Tfap2a/b and Gata3 as critical coordinators of this progenitor cell progression. This study provides a better understanding of the cellular origin of the renal collecting duct system and associated urinary tract developmental diseases, which may inform guided differentiation of functional kidney tissue.The kidney and upper urinary tract develop through reciprocal interactions between the ureteric bud and the surrounding mesenchyme. Ureteric bud branching forms the arborized collecting duct system of the kidney, while ureteric tips promote nephron formation from dedicated progenitor cells. While nephron progenitor cells are relatively well characterized, the origin of ureteric bud progenitors has received little attention so far. It is well established that the ureteric bud is induced from the nephric duct, an epithelial duct derived from the intermediate mesoderm of the embryo. However, the cell state transitions underlying the progression from intermediate mesoderm to nephric duct and ureteric bud remain unknown. Here we show that nephric duct morphogenesis results from the coordinated organization of four major progenitor cell populations. Using single cell RNA-seq and Cluster RNA-seq, we show that these progenitors emerge in time and space according to a stereotypical pattern. We identify the transcription factors Tfap2a/b and Gata3 as critical coordinators of this progenitor cell progression. This study provides a better understanding of the cellular origin of the renal collecting duct system and associated urinary tract developmental diseases, which may inform guided differentiation of functional kidney tissue.
The kidney and upper urinary tract develop through reciprocal interactions between the ureteric bud and the surrounding mesenchyme. Ureteric bud branching forms the arborized collecting duct system of the kidney, while ureteric tips promote nephron formation from dedicated progenitor cells. While nephron progenitor cells are relatively well characterized, the origin of ureteric bud progenitors has received little attention so far. It is well established that the ureteric bud is induced from the nephric duct, an epithelial duct derived from the intermediate mesoderm of the embryo. However, the cell state transitions underlying the progression from intermediate mesoderm to nephric duct and ureteric bud remain unknown. Here we show that nephric duct morphogenesis results from the coordinated organization of four major progenitor cell populations. Using single cell RNA-seq and Cluster RNA-seq, we show that these progenitors emerge in time and space according to a stereotypical pattern. We identify the transcription factors Tfap2a/b and Gata3 as critical coordinators of this progenitor cell progression. This study provides a better understanding of the cellular origin of the renal collecting duct system and associated urinary tract developmental diseases, which may inform guided differentiation of functional kidney tissue. Nephric duct (ND)-derived ureteric buds (UB) form the kidney collecting duct system, while ureteric tips promote nephron formation. Here the authors use single-cell RNA-seq and introduce Cluster RNA-seq to identify four progenitor populations in developing ND/UB regulated by the transcription factors Tfap2a/b and Gata3.
Nephric duct (ND)-derived ureteric buds (UB) form the kidney collecting duct system, while ureteric tips promote nephron formation. Here the authors use single-cell RNA-seq and introduce Cluster RNA-seq to identify four progenitor populations in developing ND/UB regulated by the transcription factors Tfap2a/b and Gata3.
The kidney and upper urinary tract develop through reciprocal interactions between the ureteric bud and the surrounding mesenchyme. Ureteric bud branching forms the arborized collecting duct system of the kidney, while ureteric tips promote nephron formation from dedicated progenitor cells. While nephron progenitor cells are relatively well characterized, the origin of ureteric bud progenitors has received little attention so far. It is well established that the ureteric bud is induced from the nephric duct, an epithelial duct derived from the intermediate mesoderm of the embryo. However, the cell state transitions underlying the progression from intermediate mesoderm to nephric duct and ureteric bud remain unknown. Here we show that nephric duct morphogenesis results from the coordinated organization of four major progenitor cell populations. Using single cell RNA-seq and Cluster RNA-seq, we show that these progenitors emerge in time and space according to a stereotypical pattern. We identify the transcription factors Tfap2a/b and Gata3 as critical coordinators of this progenitor cell progression. This study provides a better understanding of the cellular origin of the renal collecting duct system and associated urinary tract developmental diseases, which may inform guided differentiation of functional kidney tissue. Nephric duct (ND)-derived ureteric buds (UB) form the kidney collecting duct system, while ureteric tips promote nephron formation. Here the authors use single-cell RNA-seq and introduce Cluster RNA-seq to identify four progenitor populations in developing ND/UB regulated by the transcription factors Tfap2a/b and Gata3.
ArticleNumber 2627
Author Wang, Yu Chang
Bourque, Guillaume
Pacis, Alain
Ragoussis, Jiannis
Zhang, Yuhong
Sotiropoulou, Maria
Bourgey, Mathieu
Sanchez-Ferras, Oraly
Bouchard, Maxime
Author_xml – sequence: 1
  givenname: Oraly
  orcidid: 0000-0002-8054-0693
  surname: Sanchez-Ferras
  fullname: Sanchez-Ferras, Oraly
  organization: Goodman Cancer Research Centre and Department of Biochemistry, McGill University
– sequence: 2
  givenname: Alain
  surname: Pacis
  fullname: Pacis, Alain
  organization: Goodman Cancer Research Centre and Department of Biochemistry, McGill University, Canadian Centre for Computational Genomics, McGill University
– sequence: 3
  givenname: Maria
  surname: Sotiropoulou
  fullname: Sotiropoulou, Maria
  organization: Department for Human Genetics, McGill University Genome Centre, McGill University
– sequence: 4
  givenname: Yuhong
  surname: Zhang
  fullname: Zhang, Yuhong
  organization: Goodman Cancer Research Centre and Department of Biochemistry, McGill University
– sequence: 5
  givenname: Yu Chang
  surname: Wang
  fullname: Wang, Yu Chang
  organization: Department for Human Genetics, McGill University Genome Centre, McGill University
– sequence: 6
  givenname: Mathieu
  surname: Bourgey
  fullname: Bourgey, Mathieu
  organization: Canadian Centre for Computational Genomics, McGill University, Department for Human Genetics, McGill University Genome Centre, McGill University
– sequence: 7
  givenname: Guillaume
  orcidid: 0000-0002-3933-9656
  surname: Bourque
  fullname: Bourque, Guillaume
  organization: Canadian Centre for Computational Genomics, McGill University, Department for Human Genetics, McGill University Genome Centre, McGill University
– sequence: 8
  givenname: Jiannis
  orcidid: 0000-0002-8515-0934
  surname: Ragoussis
  fullname: Ragoussis, Jiannis
  organization: Department for Human Genetics, McGill University Genome Centre, McGill University, Department of Bioengineering, McGill University
– sequence: 9
  givenname: Maxime
  orcidid: 0000-0002-7619-9680
  surname: Bouchard
  fullname: Bouchard, Maxime
  email: maxime.bouchard@mcgill.ca
  organization: Goodman Cancer Research Centre and Department of Biochemistry, McGill University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33976190$$D View this record in MEDLINE/PubMed
BookMark eNp9kk1v1DAQhi1URD_oH-CAInHhEvB4nMS-IFUV0EqVuIA4Wl57sniVjRc7qcS_x7sppe2hvvjred8Ze-aUHY1xJMbeAP8AHNXHLEG2Xc0F1EJohLp5wU4El1BDJ_DowfqYnee84WWgBiXlK3aMqLsWND9hPy8qF2PyYbQT-WqX4jpRziGOVewPWxrDFFPlaBiqPBUqV6EchcNqTkWY_lRTsm6qPN3SEHdbGqfX7GVvh0znd_MZ-_Hl8_fLq_rm29fry4ub2jWST7VApTnX0AH6lVNAgKCVVKStwEbLllvr0XvXEjjeotCOdyuiVW81ekQ8Y9eLr492Y3YpbEs6JtpgDgcxrY1NU3ADGUF922nfOAFWet7YHqyCXiqhug6lLF6fFq_dvNqSd-UZyQ6PTB_fjOGXWcdbowBQtF0xeH9nkOLvmfJktiHvP86OFOdsRCNaQCWgKei7J-gmzmksX7WnGiGawhXq7cOM7lP5V78CiAVwKeacqL9HgJt9n5ilT0zpE3PoE7OPrZ6IXCiFLTUvrwrD81JcpLnEGdeU_qf9jOovUBjRbg
CitedBy_id crossref_primary_10_1093_bib_bbae571
crossref_primary_10_1360_TB_2025_0160
crossref_primary_10_1016_j_humpath_2022_06_016
crossref_primary_10_3389_fonc_2025_1605192
crossref_primary_10_1016_j_anndiagpath_2022_152007
crossref_primary_10_1038_s41467_023_37992_x
crossref_primary_10_1097_TP_0000000000004466
crossref_primary_10_25259_IJN_77_2024
crossref_primary_10_1038_s41581_025_00951_4
crossref_primary_10_1186_s43556_023_00144_0
crossref_primary_10_1038_s41581_024_00841_1
crossref_primary_10_1038_s41467_022_29644_3
crossref_primary_10_1186_s12915_022_01309_z
crossref_primary_10_1038_s41587_022_01429_5
crossref_primary_10_1038_s41592_022_01480_9
crossref_primary_10_1097_MNH_0000000000000781
crossref_primary_10_3389_fmed_2024_1374653
crossref_primary_10_1016_j_tem_2023_05_007
crossref_primary_10_1152_ajprenal_00116_2025
crossref_primary_10_1038_s41596_023_00847_2
crossref_primary_10_1093_nar_gkad583
crossref_primary_10_3389_fcell_2024_1395723
crossref_primary_10_3389_fmed_2022_873923
crossref_primary_10_1016_j_ajpath_2024_06_012
Cites_doi 10.1038/nbt.2859
10.1242/dev.126.6.1103
10.1016/j.devcel.2017.04.022
10.1038/381238a0
10.1038/367380a0
10.1016/j.ajhg.2008.03.005
10.1016/j.devcel.2018.05.010
10.1242/dev.005033
10.1146/annurev-physiol-020518-114331
10.1038/nature20123
10.1016/j.jss.2018.02.038
10.1016/j.devcel.2010.04.008
10.1016/j.semnephrol.2010.06.004
10.1016/bs.ctdb.2015.10.010
10.1038/nbt.1754
10.1038/ncomms12139
10.1038/nrneph.2015.140
10.1002/dvdy.22640
10.1016/S0378-1119(00)00454-6
10.1016/j.stem.2008.05.020
10.1038/nrg2205
10.1038/s41586-019-0933-9
10.1093/nar/gku936
10.1002/dvdy.24241
10.1016/j.cell.2014.09.038
10.1038/sj.emboj.7601381
10.1242/dev.124.9.1653
10.1016/j.stem.2017.10.011
10.1101/gr.234807.118
10.1002/med.20231
10.1038/35019088
10.1172/JCI41619
10.1002/ajmg.a.32619
10.1371/journal.pbio.1000009
10.1016/j.devcel.2019.10.005
10.1242/dev.01833
10.1016/j.ydbio.2013.07.028
10.1126/science.aaf2403
10.1016/j.ydbio.2008.10.012
10.1038/nbt.4096
10.1681/ASN.2015010096
10.1101/gad.11.15.1938
10.1111/j.1439-0264.1998.tb00194.x
10.1101/gad.240102
10.1681/ASN.2017080890
10.1016/j.stem.2013.11.010
10.1242/dev.122408
10.1101/gad.1387206
10.1038/nbt.3392
10.1038/nature15695
10.1016/j.ydbio.2008.03.044
10.1016/j.celrep.2020.107963
10.1016/j.devcel.2015.12.010
10.1093/bioinformatics/btw561
10.1186/1471-2105-14-128
10.1038/ki.2013.508
10.1016/j.ajhg.2007.10.008
10.1111/j.1399-0004.2009.01175.x
10.1038/s41467-020-14482-y
10.1242/dev.056838
10.1006/dbio.2000.9623
10.1111/dgd.12047
10.1242/dev.02184
10.1186/s12864-020-06832-3
10.1038/cr.2017.81
10.1007/978-1-61779-851-1_4
10.1002/gene.10079
10.1242/dev.042226
10.1038/ki.2014.358
10.1016/j.kint.2019.03.017
10.1210/jc.2009-0717
10.1242/dev.129.2.307
10.1007/s00467-013-2684-4
10.1242/dev.178673
10.1242/dev.149955
10.1053/j.gastro.2020.07.018
10.1007/s00467-013-2635-0
10.1242/dev.182162
10.1016/j.semcdb.2015.09.016
10.1002/bies.20357
10.1101/cshperspect.a008300
10.1016/j.semcdb.2018.08.015
10.1101/2020.04.27.049031
10.1016/j.semcdb.2014.09.001
10.1371/journal.pgen.1000316
10.1242/dev.172387
10.1371/journal.pone.0021529
ContentType Journal Article
Copyright The Author(s) 2021
The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2021
– notice: The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-021-22931-5
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Computer Science Collection
ProQuest Central Essentials Local Electronic Collection Information
Biological Science Collection
ProQuest Central
Technology collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
PML(ProQuest Medical Library)
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef
MEDLINE - Academic

MEDLINE


Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: PIMPY
  name: Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 16
ExternalDocumentID oai_doaj_org_article_2ef679d5c21a4d05af1a81f482877344
PMC8113267
33976190
10_1038_s41467_021_22931_5
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: KRESCENT postdoctoral fellowship MICRTP postdoctoral fellowship Canderel postdoctoral fellowships
– fundername: Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)
  grantid: CIHR PJT-159768
  funderid: https://doi.org/10.13039/501100000024
– fundername: Kidney Foundation of Canada (La Fondation canadienne du rein)
  grantid: KFOC180002
  funderid: https://doi.org/10.13039/501100000191
– fundername: CIHR
  grantid: PJT-159768
– fundername: ;
– fundername: ;
  grantid: CIHR PJT-159768
– fundername: ;
  grantid: KFOC180002
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
AFFHD
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
CGR
CUY
CVF
ECM
EIF
NPM
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
SOI
7X8
5PM
ID FETCH-LOGICAL-c540t-23890091713dbc81e1319848e9a2359460aad3ddc6e1c06329c07beebfa93d333
IEDL.DBID DOA
ISICitedReferencesCount 29
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000658723000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 2041-1723
IngestDate Fri Oct 03 12:42:19 EDT 2025
Tue Nov 04 02:03:58 EST 2025
Sun Nov 09 09:26:19 EST 2025
Tue Oct 07 06:47:48 EDT 2025
Mon Jul 21 06:01:11 EDT 2025
Tue Nov 18 21:04:29 EST 2025
Sat Nov 29 06:29:18 EST 2025
Fri Feb 21 02:39:00 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-23890091713dbc81e1319848e9a2359460aad3ddc6e1c06329c07beebfa93d333
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-8054-0693
0000-0002-8515-0934
0000-0002-3933-9656
0000-0002-7619-9680
OpenAccessLink https://doaj.org/article/2ef679d5c21a4d05af1a81f482877344
PMID 33976190
PQID 2525225382
PQPubID 546298
PageCount 16
ParticipantIDs doaj_primary_oai_doaj_org_article_2ef679d5c21a4d05af1a81f482877344
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8113267
proquest_miscellaneous_2526138215
proquest_journals_2525225382
pubmed_primary_33976190
crossref_primary_10_1038_s41467_021_22931_5
crossref_citationtrail_10_1038_s41467_021_22931_5
springer_journals_10_1038_s41467_021_22931_5
PublicationCentury 2000
PublicationDate 2021-05-11
PublicationDateYYYYMMDD 2021-05-11
PublicationDate_xml – month: 05
  year: 2021
  text: 2021-05-11
  day: 11
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2021
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Ransick (CR9) 2019; 51
Toka, Toka, Hariri, Nguyen (CR66) 2010; 30
Skinner, Safford, Reeves, Jackson, Freemerman (CR40) 2008; 82
Itaranta (CR50) 2002; 32
Attia, Schneider, Yelin, Schultheiss (CR22) 2015; 244
Vazquez (CR27) 1998; 27
Jain (CR41) 2010; 120
Stahl (CR57) 2016; 353
Sharmin (CR13) 2016; 27
Linton, Martin, Reichardt (CR51) 2007; 134
Nichterwitz (CR54) 2016; 7
Park, Lim, Kim, Bae (CR81) 2017; 33
Mugford, Sipila, Kobayashi, Behringer, McMahon (CR25) 2008; 319
CR38
CR36
CR34
CR78
CR77
CR32
Tirosh (CR85) 2016; 539
Taguchi, Nishinakamura (CR5) 2017; 21
CR75
CR73
Grote, Marcotte, Bouchard (CR23) 2012; 886
Gaynor (CR39) 2009; 94
Georgas, Chiu, Lesieur, Rumballe, Little (CR24) 2011; 240
Chia (CR35) 2011; 138
Hilger-Eversheim, Moser, Schorle, Buettner (CR69) 2000; 260
Bouchard, Souabni, Mandler, Neubüser, Busslinger (CR16) 2002; 16
Schedl (CR31) 2007; 8
Bouchard (CR47) 2005; 132
Zuo (CR79) 2017; 27
Moser (CR68) 1997; 11
Foley (CR53) 2019; 29
Brinkman, Chen, Amendola, van Steensel (CR80) 2014; 42
CR2
Zhang, Ntranos, Tse (CR84) 2020; 11
Obara-Ishihara, Kuhlman, Niswander, Herzlinger (CR17) 1999; 126
Van Esch (CR65) 2000; 406
Bergenstrahle, Larsson, Lundeberg (CR58) 2020; 21
Little, Hale, Howden, Kumar (CR8) 2019; 81
Taguchi, Nishinakamura (CR4) 2015; 87
Li, Arora, Chen, McCulloch, Liu (CR48) 2012; 32
CR45
Lindstrom (CR14) 2018; 45
CR88
Uetani, Bouchard (CR28) 2009; 75
Vasilyev (CR74) 2009; 7
Boualia (CR49) 2013; 382
Pfeffer, Payer, Reim, di Magliano, Busslinger (CR44) 2002; 129
McMahon (CR3) 2016; 117
Hwang (CR67) 2014; 85
Mae (CR76) 2020; 32
Wang (CR70) 2018; 227
Milunsky (CR72) 2008; 82
Sharma, Shafer, Bareke, Tremblay, Majewski (CR46) 2017; 144
Trapnell (CR86) 2014; 32
Nicolaou, Renkema, Bongers, Giles, Knoers (CR43) 2015; 11
CR19
Mauch, Yang, Wright, Smith, Schoenwolf (CR18) 2000; 220
Robinson (CR82) 2011; 29
Lindstrom (CR15) 2018; 29
Takasato (CR7) 2015; 526
CR52
Miyamoto, Yoshida, Kuratani, Matsuo, Aizawa (CR37) 1997; 124
Butler, Hoffman, Smibert, Papalexi, Satija (CR83) 2018; 36
Zhang (CR60) 1996; 381
Knoers, Renkema (CR30) 2019; 96
Morizane (CR61) 2015; 33
Lokmane, Heliot, Garcia-Villalba, Fabre, Cereghini (CR62) 2010; 137
Chen (CR87) 2013; 14
Tekin, Sirmaci, Yuksel-Konuk, Fitoz, Sennaroglu (CR71) 2009; 149A
Atsuta, Tadokoro, Saito, Takahashi (CR21) 2013; 55
Pijuan-Sala (CR59) 2019; 566
Joseph, Yao, Hinton (CR26) 2009; 325
CR29
Kobayashi (CR11) 2008; 3
Wu (CR55) 2016; 36
Schuchardt, D’Agati, Larsson-Blomberg, Costantini, Pachnis (CR64) 1994; 367
Naiman (CR10) 2017; 41
Junker (CR56) 2014; 159
Costantini, Kopan (CR1) 2010; 18
CR63
Taguchi (CR6) 2014; 14
Self (CR12) 2006; 25
Atsuta, Takahashi (CR20) 2015; 142
Grote, Souabni, Busslinger, Bouchard (CR33) 2006; 133
Jain, Encinas, Johnson, Milbrandt (CR42) 2006; 20
M Moser (22931_CR68) 1997; 11
SI Mae (22931_CR76) 2020; 32
D Grote (22931_CR33) 2006; 133
HR Toka (22931_CR66) 2010; 30
T Obara-Ishihara (22931_CR17) 1999; 126
Y Atsuta (22931_CR20) 2015; 142
A Schedl (22931_CR31) 2007; 8
P Itaranta (22931_CR50) 2002; 32
NO Lindstrom (22931_CR14) 2018; 45
MA Skinner (22931_CR40) 2008; 82
22931_CR38
CC Wu (22931_CR55) 2016; 36
K Hilger-Eversheim (22931_CR69) 2000; 260
JT Robinson (22931_CR82) 2011; 29
A Taguchi (22931_CR4) 2015; 87
22931_CR36
PL Pfeffer (22931_CR44) 2002; 129
A Taguchi (22931_CR5) 2017; 21
22931_CR34
22931_CR78
GH Li (22931_CR48) 2012; 32
22931_CR32
SK Boualia (22931_CR49) 2013; 382
22931_CR77
22931_CR75
N Uetani (22931_CR28) 2009; 75
I Tirosh (22931_CR85) 2016; 539
L Lokmane (22931_CR62) 2010; 137
22931_CR73
EK Brinkman (22931_CR80) 2014; 42
I Chia (22931_CR35) 2011; 138
M Bouchard (22931_CR47) 2005; 132
KU Gaynor (22931_CR39) 2009; 94
M Bouchard (22931_CR16) 2002; 16
M Tekin (22931_CR71) 2009; 149A
A Kobayashi (22931_CR11) 2008; 3
E Zuo (22931_CR79) 2017; 27
22931_CR29
MH Little (22931_CR8) 2019; 81
N Knoers (22931_CR30) 2019; 96
S Jain (22931_CR41) 2010; 120
JP Junker (22931_CR56) 2014; 159
J Bergenstrahle (22931_CR58) 2020; 21
EY Chen (22931_CR87) 2013; 14
S Jain (22931_CR42) 2006; 20
JW Mugford (22931_CR25) 2008; 319
22931_CR63
A Joseph (22931_CR26) 2009; 325
TJ Mauch (22931_CR18) 2000; 220
DY Hwang (22931_CR67) 2014; 85
C Trapnell (22931_CR86) 2014; 32
B Pijuan-Sala (22931_CR59) 2019; 566
R Morizane (22931_CR61) 2015; 33
J Zhang (22931_CR60) 1996; 381
H Van Esch (22931_CR65) 2000; 406
L Attia (22931_CR22) 2015; 244
22931_CR19
N Naiman (22931_CR10) 2017; 41
JW Foley (22931_CR53) 2019; 29
N Miyamoto (22931_CR37) 1997; 124
22931_CR52
N Nicolaou (22931_CR43) 2015; 11
JM Linton (22931_CR51) 2007; 134
S Nichterwitz (22931_CR54) 2016; 7
JM Milunsky (22931_CR72) 2008; 82
J Park (22931_CR81) 2017; 33
A Butler (22931_CR83) 2018; 36
Y Atsuta (22931_CR21) 2013; 55
D Grote (22931_CR23) 2012; 886
MD Vazquez (22931_CR27) 1998; 27
R Sharma (22931_CR46) 2017; 144
A Vasilyev (22931_CR74) 2009; 7
A Ransick (22931_CR9) 2019; 51
A Schuchardt (22931_CR64) 1994; 367
S Sharmin (22931_CR13) 2016; 27
M Takasato (22931_CR7) 2015; 526
F Costantini (22931_CR1) 2010; 18
AP McMahon (22931_CR3) 2016; 117
PL Stahl (22931_CR57) 2016; 353
22931_CR45
NO Lindstrom (22931_CR15) 2018; 29
22931_CR88
22931_CR2
A Taguchi (22931_CR6) 2014; 14
MJ Zhang (22931_CR84) 2020; 11
J Wang (22931_CR70) 2018; 227
M Self (22931_CR12) 2006; 25
KM Georgas (22931_CR24) 2011; 240
References_xml – ident: CR45
– volume: 32
  start-page: 381
  year: 2014
  end-page: 386
  ident: CR86
  article-title: The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2859
– volume: 126
  start-page: 1103
  year: 1999
  end-page: 1108
  ident: CR17
  article-title: The surface ectoderm is essential for nephric duct formation in intermediate mesoderm
  publication-title: Development
  doi: 10.1242/dev.126.6.1103
– volume: 41
  start-page: 349
  year: 2017
  end-page: 365.e343
  ident: CR10
  article-title: Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2017.04.022
– volume: 381
  start-page: 238
  year: 1996
  end-page: 241
  ident: CR60
  article-title: Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2
  publication-title: Nature
  doi: 10.1038/381238a0
– volume: 367
  start-page: 380
  year: 1994
  end-page: 383
  ident: CR64
  article-title: Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
  publication-title: Nature
  doi: 10.1038/367380a0
– volume: 82
  start-page: 1171
  year: 2008
  end-page: 1177
  ident: CR72
  article-title: TFAP2A mutations result in branchio-oculo-facial syndrome
  publication-title: Am. J. Hum. Genet
  doi: 10.1016/j.ajhg.2008.03.005
– volume: 45
  start-page: 651
  year: 2018
  end-page: 660.e654
  ident: CR14
  article-title: Progressive Recruitment of Mesenchymal Progenitors Reveals a Time-Dependent Process of Cell Fate Acquisition in Mouse and Human Nephrogenesis
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2018.05.010
– volume: 134
  start-page: 2501
  year: 2007
  end-page: 2509
  ident: CR51
  article-title: The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression
  publication-title: Development
  doi: 10.1242/dev.005033
– volume: 81
  start-page: 335
  year: 2019
  end-page: 357
  ident: CR8
  article-title: Generating Kidney from Stem Cells
  publication-title: Annu. Rev. Physiol.
  doi: 10.1146/annurev-physiol-020518-114331
– volume: 539
  start-page: 309
  year: 2016
  end-page: 313
  ident: CR85
  article-title: Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
  publication-title: Nature
  doi: 10.1038/nature20123
– ident: CR29
– volume: 227
  start-page: 178
  year: 2018
  end-page: 185
  ident: CR70
  article-title: Tfap2b mutation in mice results in patent ductus arteriosus and renal malformation
  publication-title: J. Surg. Res
  doi: 10.1016/j.jss.2018.02.038
– ident: CR77
– volume: 18
  start-page: 698
  year: 2010
  end-page: 712
  ident: CR1
  article-title: Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2010.04.008
– volume: 30
  start-page: 374
  year: 2010
  end-page: 386
  ident: CR66
  article-title: Congenital anomalies of kidney and urinary tract
  publication-title: Semin. Nephrol.
  doi: 10.1016/j.semnephrol.2010.06.004
– volume: 117
  start-page: 31
  year: 2016
  end-page: 64
  ident: CR3
  article-title: Development of the Mammalian Kidney
  publication-title: Curr. Top. Dev. Biol.
  doi: 10.1016/bs.ctdb.2015.10.010
– volume: 29
  start-page: 24
  year: 2011
  end-page: 26
  ident: CR82
  article-title: Integrative genomics viewer
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1754
– volume: 7
  year: 2016
  ident: CR54
  article-title: Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms12139
– volume: 11
  start-page: 720
  year: 2015
  end-page: 731
  ident: CR43
  article-title: Genetic, environmental, and epigenetic factors involved in CAKUT
  publication-title: Nat. Rev. Nephrol.
  doi: 10.1038/nrneph.2015.140
– volume: 240
  start-page: 1600
  year: 2011
  end-page: 1612
  ident: CR24
  article-title: Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.22640
– volume: 260
  start-page: 1
  year: 2000
  end-page: 12
  ident: CR69
  article-title: Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control
  publication-title: Gene
  doi: 10.1016/S0378-1119(00)00454-6
– volume: 3
  start-page: 169
  year: 2008
  end-page: 181
  ident: CR11
  article-title: Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.05.020
– ident: CR19
– volume: 8
  start-page: 791
  year: 2007
  end-page: 802
  ident: CR31
  article-title: Renal abnormalities and their developmental origin
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2205
– volume: 566
  start-page: 490
  year: 2019
  end-page: 495
  ident: CR59
  article-title: A single-cell molecular map of mouse gastrulation and early organogenesis
  publication-title: Nature
  doi: 10.1038/s41586-019-0933-9
– ident: CR75
– volume: 42
  start-page: e168
  year: 2014
  ident: CR80
  article-title: Easy quantitative assessment of genome editing by sequence trace decomposition
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku936
– ident: CR88
– volume: 244
  start-page: 157
  year: 2015
  end-page: 167
  ident: CR22
  article-title: Collective cell migration of the nephric duct requires FGF signaling
  publication-title: Dev. Dyn.: Off. Publ. Am. Assoc. Anatomists
  doi: 10.1002/dvdy.24241
– volume: 159
  start-page: 662
  year: 2014
  end-page: 675
  ident: CR56
  article-title: Genome-wide RNA Tomography in the zebrafish embryo
  publication-title: Cell
  doi: 10.1016/j.cell.2014.09.038
– volume: 25
  start-page: 5214
  year: 2006
  end-page: 5228
  ident: CR12
  article-title: Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7601381
– volume: 124
  start-page: 1653
  year: 1997
  end-page: 1664
  ident: CR37
  article-title: Defects of urogenital development in mice lacking Emx2
  publication-title: Dev. (Camb., Engl.)
  doi: 10.1242/dev.124.9.1653
– volume: 21
  start-page: 730
  year: 2017
  end-page: 746.e736
  ident: CR5
  article-title: Higher-Order Kidney Organogenesis from Pluripotent Stem Cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2017.10.011
– volume: 29
  start-page: 1816
  year: 2019
  end-page: 1825
  ident: CR53
  article-title: Gene expression profiling of single cells from archival tissue with laser-capture microdissection and Smart-3SEQ
  publication-title: Genome Res
  doi: 10.1101/gr.234807.118
– volume: 32
  start-page: 999
  year: 2012
  end-page: 1025
  ident: CR48
  article-title: Multifunctional roles of gelsolin in health and diseases
  publication-title: Med. Res. Rev.
  doi: 10.1002/med.20231
– ident: CR32
– volume: 406
  start-page: 419
  year: 2000
  end-page: 422
  ident: CR65
  article-title: GATA3 haplo-insufficiency causes human HDR syndrome
  publication-title: Nature
  doi: 10.1038/35019088
– ident: CR36
– volume: 120
  start-page: 778
  year: 2010
  end-page: 790
  ident: CR41
  article-title: Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI41619
– volume: 149A
  start-page: 427
  year: 2009
  end-page: 430
  ident: CR71
  article-title: A complex TFAP2A allele is associated with branchio-oculo-facial syndrome and inner ear malformation in a deaf child
  publication-title: Am. J. Med. Genet A
  doi: 10.1002/ajmg.a.32619
– volume: 7
  start-page: e9
  year: 2009
  ident: CR74
  article-title: Collective cell migration drives morphogenesis of the kidney nephron
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.1000009
– ident: CR78
– volume: 51
  start-page: 399
  year: 2019
  end-page: 413.e397
  ident: CR9
  article-title: Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2019.10.005
– volume: 132
  start-page: 2633
  year: 2005
  end-page: 2643
  ident: CR47
  article-title: Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region
  publication-title: Development
  doi: 10.1242/dev.01833
– volume: 382
  start-page: 555
  year: 2013
  end-page: 566
  ident: CR49
  article-title: A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2013.07.028
– volume: 353
  start-page: 78
  year: 2016
  end-page: 82
  ident: CR57
  article-title: Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
  publication-title: Science
  doi: 10.1126/science.aaf2403
– volume: 325
  start-page: 6
  year: 2009
  end-page: 14
  ident: CR26
  article-title: Development and morphogenesis of the Wolffian/epididymal duct, more twists and turns
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2008.10.012
– volume: 36
  start-page: 411
  year: 2018
  end-page: 420
  ident: CR83
  article-title: Integrating single-cell transcriptomic data across different conditions, technologies, and species
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4096
– volume: 27
  start-page: 1778
  year: 2016
  end-page: 1791
  ident: CR13
  article-title: Human Induced Pluripotent Stem Cell-Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2015010096
– volume: 11
  start-page: 1938
  year: 1997
  end-page: 1948
  ident: CR68
  article-title: Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta
  publication-title: Genes Dev.
  doi: 10.1101/gad.11.15.1938
– volume: 144
  start-page: 2982
  year: 2017
  end-page: 2993
  ident: CR46
  article-title: Bouchard Maxime Bmp signaling maintains a mesoderm progenitor cell state in the mouse tailbud
  publication-title: Development
– volume: 27
  start-page: 283
  year: 1998
  end-page: 287
  ident: CR27
  article-title: 3D reconstruction of the mouse’s mesonephros
  publication-title: Anat. Histol. Embryol.
  doi: 10.1111/j.1439-0264.1998.tb00194.x
– ident: CR2
– volume: 16
  start-page: 2958
  year: 2002
  end-page: 2970
  ident: CR16
  article-title: Nephric lineage specification by Pax2 and Pax8
  publication-title: Genes Dev.
  doi: 10.1101/gad.240102
– volume: 29
  start-page: 806
  year: 2018
  end-page: 824
  ident: CR15
  article-title: Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2017080890
– volume: 14
  start-page: 53
  year: 2014
  end-page: 67
  ident: CR6
  article-title: Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.11.010
– volume: 142
  start-page: 2329
  year: 2015
  end-page: 2337
  ident: CR20
  article-title: FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis
  publication-title: Dev. (Camb., Engl.)
  doi: 10.1242/dev.122408
– volume: 20
  start-page: 321
  year: 2006
  end-page: 333
  ident: CR42
  article-title: Critical and distinct roles for key RET tyrosine docking sites in renal
  publication-title: Dev. Genes Dev.
  doi: 10.1101/gad.1387206
– volume: 33
  start-page: 1193
  year: 2015
  end-page: 1200
  ident: CR61
  article-title: Nephron organoids derived from human pluripotent stem cells model kidney development and injury
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3392
– volume: 526
  start-page: 564
  year: 2015
  end-page: 568
  ident: CR7
  article-title: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
  publication-title: Nature
  doi: 10.1038/nature15695
– volume: 319
  start-page: 396
  year: 2008
  end-page: 405
  ident: CR25
  article-title: Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2008.03.044
– volume: 32
  start-page: 107963
  year: 2020
  ident: CR76
  article-title: Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.107963
– volume: 36
  start-page: 36
  year: 2016
  end-page: 49
  ident: CR55
  article-title: Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2015.12.010
– volume: 33
  start-page: 286
  year: 2017
  end-page: 288
  ident: CR81
  article-title: Cas-analyzer: an online tool for assessing genome editing results using NGS data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btw561
– volume: 14
  year: 2013
  ident: CR87
  article-title: Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
  publication-title: BMC Bioinforma.
  doi: 10.1186/1471-2105-14-128
– ident: CR63
– volume: 85
  start-page: 1429
  year: 2014
  end-page: 1433
  ident: CR67
  article-title: Mutations in 12 known dominant disease-causing genes clarify many congenital anomalies of the kidney and urinary tract
  publication-title: Kidney Int.
  doi: 10.1038/ki.2013.508
– volume: 82
  start-page: 344
  year: 2008
  end-page: 351
  ident: CR40
  article-title: Renal Aplasia in Humans Is Associated with RET Mutations
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2007.10.008
– volume: 75
  start-page: 307
  year: 2009
  end-page: 317
  ident: CR28
  article-title: Plumbing in the embryo: Developmental defects of the urinary tracts
  publication-title: Clin. Genet.
  doi: 10.1111/j.1399-0004.2009.01175.x
– ident: CR73
– volume: 11
  year: 2020
  ident: CR84
  article-title: Determining sequencing depth in a single-cell RNA-seq experiment
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-14482-y
– volume: 138
  start-page: 2089
  year: 2011
  end-page: 2097
  ident: CR35
  article-title: Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice
  publication-title: Development
  doi: 10.1242/dev.056838
– volume: 220
  start-page: 62
  year: 2000
  end-page: 75
  ident: CR18
  article-title: Signals from trunk paraxial mesoderm induce pronephros formation in chick intermediate mesoderm
  publication-title: Dev. Biol.
  doi: 10.1006/dbio.2000.9623
– volume: 55
  start-page: 579
  year: 2013
  end-page: 590
  ident: CR21
  article-title: Transgenesis of the Wolffian duct visualizes dynamic behavior of cells undergoing tubulogenesis in vivo
  publication-title: Dev. Growth Differ.
  doi: 10.1111/dgd.12047
– volume: 133
  start-page: 53
  year: 2006
  end-page: 61
  ident: CR33
  article-title: Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney
  publication-title: Dev. (Camb., Engl.)
  doi: 10.1242/dev.02184
– ident: CR38
– volume: 21
  year: 2020
  ident: CR58
  article-title: Seamless integration of image and molecular analysis for spatial transcriptomics workflows
  publication-title: BMC Genom.
  doi: 10.1186/s12864-020-06832-3
– volume: 27
  start-page: 933
  year: 2017
  end-page: 945
  ident: CR79
  article-title: One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs
  publication-title: Cell Res.
  doi: 10.1038/cr.2017.81
– ident: CR52
– volume: 886
  start-page: 31
  year: 2012
  end-page: 43
  ident: CR23
  article-title: Live imaging of the developing mouse mesonephros
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-61779-851-1_4
– ident: CR34
– volume: 32
  start-page: 259
  year: 2002
  end-page: 268
  ident: CR50
  article-title: Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro
  publication-title: Genesis
  doi: 10.1002/gene.10079
– volume: 137
  start-page: 347
  year: 2010
  end-page: 357
  ident: CR62
  article-title: vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis
  publication-title: Development
  doi: 10.1242/dev.042226
– volume: 87
  start-page: 894
  year: 2015
  end-page: 900
  ident: CR4
  article-title: Nephron reconstitution from pluripotent stem cells
  publication-title: Kidney Int.
  doi: 10.1038/ki.2014.358
– volume: 96
  start-page: 267
  year: 2019
  end-page: 269
  ident: CR30
  article-title: The genomic landscape of CAKUT; you gain some, you lose some
  publication-title: Kidney Int
  doi: 10.1016/j.kint.2019.03.017
– volume: 94
  start-page: 3897
  year: 2009
  end-page: 3904
  ident: CR39
  article-title: A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2009-0717
– volume: 129
  start-page: 307
  year: 2002
  end-page: 318
  ident: CR44
  article-title: The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by separate enhancers
  publication-title: Dev. (Camb., Engl.)
  doi: 10.1242/dev.129.2.307
– volume: 29
  start-page: 1816
  year: 2019
  ident: 22931_CR53
  publication-title: Genome Res
  doi: 10.1101/gr.234807.118
– volume: 539
  start-page: 309
  year: 2016
  ident: 22931_CR85
  publication-title: Nature
  doi: 10.1038/nature20123
– volume: 159
  start-page: 662
  year: 2014
  ident: 22931_CR56
  publication-title: Cell
  doi: 10.1016/j.cell.2014.09.038
– volume: 7
  year: 2016
  ident: 22931_CR54
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms12139
– volume: 82
  start-page: 1171
  year: 2008
  ident: 22931_CR72
  publication-title: Am. J. Hum. Genet
  doi: 10.1016/j.ajhg.2008.03.005
– volume: 353
  start-page: 78
  year: 2016
  ident: 22931_CR57
  publication-title: Science
  doi: 10.1126/science.aaf2403
– volume: 33
  start-page: 286
  year: 2017
  ident: 22931_CR81
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btw561
– ident: 22931_CR29
  doi: 10.1007/s00467-013-2684-4
– volume: 21
  year: 2020
  ident: 22931_CR58
  publication-title: BMC Genom.
  doi: 10.1186/s12864-020-06832-3
– ident: 22931_CR52
  doi: 10.1242/dev.178673
– volume: 8
  start-page: 791
  year: 2007
  ident: 22931_CR31
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2205
– volume: 144
  start-page: 2982
  year: 2017
  ident: 22931_CR46
  publication-title: Development
  doi: 10.1242/dev.149955
– ident: 22931_CR78
– volume: 260
  start-page: 1
  year: 2000
  ident: 22931_CR69
  publication-title: Gene
  doi: 10.1016/S0378-1119(00)00454-6
– ident: 22931_CR88
  doi: 10.1053/j.gastro.2020.07.018
– volume: 14
  year: 2013
  ident: 22931_CR87
  publication-title: BMC Bioinforma.
  doi: 10.1186/1471-2105-14-128
– volume: 120
  start-page: 778
  year: 2010
  ident: 22931_CR41
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI41619
– volume: 29
  start-page: 24
  year: 2011
  ident: 22931_CR82
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1754
– volume: 7
  start-page: e9
  year: 2009
  ident: 22931_CR74
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.1000009
– volume: 32
  start-page: 381
  year: 2014
  ident: 22931_CR86
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2859
– volume: 94
  start-page: 3897
  year: 2009
  ident: 22931_CR39
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2009-0717
– volume: 129
  start-page: 307
  year: 2002
  ident: 22931_CR44
  publication-title: Dev. (Camb., Engl.)
  doi: 10.1242/dev.129.2.307
– volume: 220
  start-page: 62
  year: 2000
  ident: 22931_CR18
  publication-title: Dev. Biol.
  doi: 10.1006/dbio.2000.9623
– volume: 85
  start-page: 1429
  year: 2014
  ident: 22931_CR67
  publication-title: Kidney Int.
  doi: 10.1038/ki.2013.508
– volume: 27
  start-page: 283
  year: 1998
  ident: 22931_CR27
  publication-title: Anat. Histol. Embryol.
  doi: 10.1111/j.1439-0264.1998.tb00194.x
– ident: 22931_CR32
  doi: 10.1007/s00467-013-2635-0
– ident: 22931_CR63
  doi: 10.1242/dev.182162
– volume: 27
  start-page: 933
  year: 2017
  ident: 22931_CR79
  publication-title: Cell Res.
  doi: 10.1038/cr.2017.81
– volume: 41
  start-page: 349
  year: 2017
  ident: 22931_CR10
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2017.04.022
– volume: 149A
  start-page: 427
  year: 2009
  ident: 22931_CR71
  publication-title: Am. J. Med. Genet A
  doi: 10.1002/ajmg.a.32619
– volume: 244
  start-page: 157
  year: 2015
  ident: 22931_CR22
  publication-title: Dev. Dyn.: Off. Publ. Am. Assoc. Anatomists
  doi: 10.1002/dvdy.24241
– volume: 45
  start-page: 651
  year: 2018
  ident: 22931_CR14
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2018.05.010
– volume: 42
  start-page: e168
  year: 2014
  ident: 22931_CR80
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku936
– volume: 382
  start-page: 555
  year: 2013
  ident: 22931_CR49
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2013.07.028
– volume: 30
  start-page: 374
  year: 2010
  ident: 22931_CR66
  publication-title: Semin. Nephrol.
  doi: 10.1016/j.semnephrol.2010.06.004
– volume: 11
  year: 2020
  ident: 22931_CR84
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-14482-y
– volume: 124
  start-page: 1653
  year: 1997
  ident: 22931_CR37
  publication-title: Dev. (Camb., Engl.)
  doi: 10.1242/dev.124.9.1653
– volume: 27
  start-page: 1778
  year: 2016
  ident: 22931_CR13
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2015010096
– volume: 137
  start-page: 347
  year: 2010
  ident: 22931_CR62
  publication-title: Development
  doi: 10.1242/dev.042226
– volume: 3
  start-page: 169
  year: 2008
  ident: 22931_CR11
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.05.020
– volume: 55
  start-page: 579
  year: 2013
  ident: 22931_CR21
  publication-title: Dev. Growth Differ.
  doi: 10.1111/dgd.12047
– volume: 142
  start-page: 2329
  year: 2015
  ident: 22931_CR20
  publication-title: Dev. (Camb., Engl.)
  doi: 10.1242/dev.122408
– volume: 367
  start-page: 380
  year: 1994
  ident: 22931_CR64
  publication-title: Nature
  doi: 10.1038/367380a0
– volume: 566
  start-page: 490
  year: 2019
  ident: 22931_CR59
  publication-title: Nature
  doi: 10.1038/s41586-019-0933-9
– ident: 22931_CR45
  doi: 10.1016/j.semcdb.2015.09.016
– volume: 325
  start-page: 6
  year: 2009
  ident: 22931_CR26
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2008.10.012
– volume: 21
  start-page: 730
  year: 2017
  ident: 22931_CR5
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2017.10.011
– ident: 22931_CR38
  doi: 10.1002/bies.20357
– volume: 16
  start-page: 2958
  year: 2002
  ident: 22931_CR16
  publication-title: Genes Dev.
  doi: 10.1101/gad.240102
– volume: 33
  start-page: 1193
  year: 2015
  ident: 22931_CR61
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3392
– volume: 133
  start-page: 53
  year: 2006
  ident: 22931_CR33
  publication-title: Dev. (Camb., Engl.)
  doi: 10.1242/dev.02184
– ident: 22931_CR2
  doi: 10.1101/cshperspect.a008300
– volume: 29
  start-page: 806
  year: 2018
  ident: 22931_CR15
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2017080890
– ident: 22931_CR75
  doi: 10.1016/j.semcdb.2018.08.015
– volume: 126
  start-page: 1103
  year: 1999
  ident: 22931_CR17
  publication-title: Development
  doi: 10.1242/dev.126.6.1103
– volume: 51
  start-page: 399
  year: 2019
  ident: 22931_CR9
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2019.10.005
– volume: 14
  start-page: 53
  year: 2014
  ident: 22931_CR6
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.11.010
– ident: 22931_CR77
  doi: 10.1101/2020.04.27.049031
– volume: 886
  start-page: 31
  year: 2012
  ident: 22931_CR23
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-61779-851-1_4
– volume: 82
  start-page: 344
  year: 2008
  ident: 22931_CR40
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2007.10.008
– volume: 32
  start-page: 999
  year: 2012
  ident: 22931_CR48
  publication-title: Med. Res. Rev.
  doi: 10.1002/med.20231
– volume: 134
  start-page: 2501
  year: 2007
  ident: 22931_CR51
  publication-title: Development
  doi: 10.1242/dev.005033
– volume: 36
  start-page: 36
  year: 2016
  ident: 22931_CR55
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2015.12.010
– volume: 81
  start-page: 335
  year: 2019
  ident: 22931_CR8
  publication-title: Annu. Rev. Physiol.
  doi: 10.1146/annurev-physiol-020518-114331
– volume: 32
  start-page: 259
  year: 2002
  ident: 22931_CR50
  publication-title: Genesis
  doi: 10.1002/gene.10079
– ident: 22931_CR19
  doi: 10.1016/j.semcdb.2014.09.001
– volume: 96
  start-page: 267
  year: 2019
  ident: 22931_CR30
  publication-title: Kidney Int
  doi: 10.1016/j.kint.2019.03.017
– volume: 18
  start-page: 698
  year: 2010
  ident: 22931_CR1
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2010.04.008
– volume: 138
  start-page: 2089
  year: 2011
  ident: 22931_CR35
  publication-title: Development
  doi: 10.1242/dev.056838
– volume: 319
  start-page: 396
  year: 2008
  ident: 22931_CR25
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2008.03.044
– volume: 11
  start-page: 720
  year: 2015
  ident: 22931_CR43
  publication-title: Nat. Rev. Nephrol.
  doi: 10.1038/nrneph.2015.140
– volume: 117
  start-page: 31
  year: 2016
  ident: 22931_CR3
  publication-title: Curr. Top. Dev. Biol.
  doi: 10.1016/bs.ctdb.2015.10.010
– volume: 132
  start-page: 2633
  year: 2005
  ident: 22931_CR47
  publication-title: Development
  doi: 10.1242/dev.01833
– volume: 526
  start-page: 564
  year: 2015
  ident: 22931_CR7
  publication-title: Nature
  doi: 10.1038/nature15695
– volume: 87
  start-page: 894
  year: 2015
  ident: 22931_CR4
  publication-title: Kidney Int.
  doi: 10.1038/ki.2014.358
– volume: 11
  start-page: 1938
  year: 1997
  ident: 22931_CR68
  publication-title: Genes Dev.
  doi: 10.1101/gad.11.15.1938
– volume: 32
  start-page: 107963
  year: 2020
  ident: 22931_CR76
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.107963
– volume: 75
  start-page: 307
  year: 2009
  ident: 22931_CR28
  publication-title: Clin. Genet.
  doi: 10.1111/j.1399-0004.2009.01175.x
– volume: 381
  start-page: 238
  year: 1996
  ident: 22931_CR60
  publication-title: Nature
  doi: 10.1038/381238a0
– volume: 240
  start-page: 1600
  year: 2011
  ident: 22931_CR24
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.22640
– ident: 22931_CR34
  doi: 10.1371/journal.pgen.1000316
– ident: 22931_CR73
  doi: 10.1242/dev.172387
– volume: 20
  start-page: 321
  year: 2006
  ident: 22931_CR42
  publication-title: Dev. Genes Dev.
  doi: 10.1101/gad.1387206
– volume: 406
  start-page: 419
  year: 2000
  ident: 22931_CR65
  publication-title: Nature
  doi: 10.1038/35019088
– volume: 36
  start-page: 411
  year: 2018
  ident: 22931_CR83
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4096
– volume: 25
  start-page: 5214
  year: 2006
  ident: 22931_CR12
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7601381
– volume: 227
  start-page: 178
  year: 2018
  ident: 22931_CR70
  publication-title: J. Surg. Res
  doi: 10.1016/j.jss.2018.02.038
– ident: 22931_CR36
  doi: 10.1371/journal.pone.0021529
SSID ssj0000391844
Score 2.5103493
Snippet The kidney and upper urinary tract develop through reciprocal interactions between the ureteric bud and the surrounding mesenchyme. Ureteric bud branching...
Nephric duct (ND)-derived ureteric buds (UB) form the kidney collecting duct system, while ureteric tips promote nephron formation. Here the authors use...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 2627
SubjectTerms 13/31
13/51
14/19
38/91
631/114
631/136/142
631/136/2060
631/80
Animals
AP-2 protein
Cell Differentiation - genetics
Cells (biology)
Clusters
Collecting duct
Developmental disabilities
Embryo, Mammalian
Embryos
Female
GATA-3 protein
GATA3 Transcription Factor - metabolism
Gene Expression Regulation, Developmental
Humanities and Social Sciences
Kidneys
Male
Mesenchyme
Mesoderm
Mice
Mice, Transgenic
Models, Animal
Morphogenesis
multidisciplinary
Nephrons - embryology
Organogenesis - genetics
Populations
Progenitor cells
Ribonucleic acid
RNA
RNA-Seq
Science
Science (multidisciplinary)
Single-Cell Analysis
Stem cells
Stem Cells - physiology
Tips
Transcription Factor AP-2 - metabolism
Transcription factors
Ureter
Urinary tract
Urogenital system
SummonAdditionalLinks – databaseName: Biological Science Database
  dbid: M7P
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaggMSF9yNQkJG4QdT4lTgnVBAVp6oHEL1Zjh-wUpWUZIvUf8-M481qefSC9pLdOIqzn8fzZTz-hpDXtew0j1GVUfGulMxXYHMtL2MU4J44akz5VGyiOT7Wp6ftSQ64TTmtcjMnponaDw5j5AdcwYeDefJ35z9KrBqFq6u5hMZ1cgNVEkRK3TtZYiyofq6lzHtlKqEPJplmBsxL4ODoWKl2_FGS7f8b1_wzZfK3ddPkjo7u_u-D3CN3MhGlh_PIuU-uhf4BuTWXprx8SL4eUjfAi-mqBzLqaUrjmiU86BDT14CTwUgx8k_TtqSJrjATKR1hDN-Ol3SNm7Co32YmPSJfjj5-_vCpzEUYSgdkbl2CS2-BhzF4mfWd0ywwMFotdWgtF6qVdWWtF967OjAHfIe3rmq6ELpoW-GFEI_JXj_04Smh3KnGK2A8gIvsKtdZJeAmrgss6EaHgrANFMZlhXIslHFm0kq50GaGzwB8JsFnVEHeLNecz_ocV7Z-jwgvLVFbO_0wjN9MNlXDQ6yb1ivHmZW-UjYyq1mUWBqgEVIWZH8DrMkGP5ktqgV5tZwGU0UUbB-Gi9SmRslHBv14Mg-npScCeSGQs4I0OwNtp6u7Z_rV9yQHrhkDDt4U5O1mSG679e-_4tnVT_Gc3OZoJahTy_bJ3nq8CC_ITfdzvZrGl8nMfgFISy4i
  priority: 102
  providerName: ProQuest
Title A coordinated progression of progenitor cell states initiates urinary tract development
URI https://link.springer.com/article/10.1038/s41467-021-22931-5
https://www.ncbi.nlm.nih.gov/pubmed/33976190
https://www.proquest.com/docview/2525225382
https://www.proquest.com/docview/2526138215
https://pubmed.ncbi.nlm.nih.gov/PMC8113267
https://doaj.org/article/2ef679d5c21a4d05af1a81f482877344
Volume 12
WOSCitedRecordID wos000658723000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: DOA
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: M~E
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: M7P
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: 7X7
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest advanced technologies & aerospace journals
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: P5Z
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/hightechjournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: BENPR
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: PIMPY
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3dixMxEB_0VPBF_Hb1LBF80-U2X5vs453coQ-WRRSrLyGbDyzIVtrewf33N8lue1c_X6SwtE2WHSYzmV-yk98AvKxFp1mMsoySdaWgvkKfa1gZI8fwxBLHlM_FJtR0qmezpr1S6ivlhA30wIPiDliItWq8dIxa4StpI7WaRpGI2hUXmQkUUc-VxVSeg3mDSxcxnpKpuD5YiTwnpIwEhiGOlnInEmXC_t-hzF-TJX96Y5oD0clduDMiSHI4SH4ProX-PtwaakqeP4DPh8QtcEU57xFFepLzrwbuDbKI-WdIXrwkacue5PNEKzJPKUT5W9p8t8tzsk6np4i_TCl6CJ9Ojj--eVuO1RNKhyhsXWIsbhBAUVyF-s5pGih6mxY6NJZx2Yi6stZz710dqEOgwhpXqS6ELtqGe875I9jrF314AoQ5qbxEqIJqFV3lOis5PsR1gQatdCiAbjRp3EgtnipcfDf5FTfXZtC-Qe2brH0jC3i1vefHQKzx195HaYC2PRMpdv4DTcWMpmL-ZSoF7G-G14yeujJM4ofhtM8KeLFtRh9Lo2D7sDjNferE1UhRjseDNWwl4QnQIaoqQO3YyY6ouy39_Fvm8daUInhWBbzeWNSlWH9WxdP_oYpncJslV0g0tHQf9tbL0_Acbrqz9Xy1nMB1NVP5qidw4-h42n6YZP-apNTYFq-t_Iot7bv37ZcLB7ImjQ
linkProvider Directory of Open Access Journals
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB5VBUQvvB-BAkaCE0SNHTtxDgiVR9WqZdVDEb2ZxHboSigpu1vQ_il-IzNOsqvl0VsPKJfNxqsdx9_MfLbHMwDPMllpUdcqrpWoYsldgjpXiLiuU3RPgnJMuVBsIh-N9PFxcbgGP4ezMBRWOdjEYKhda2mNfEsovASqp3h9-i2mqlG0uzqU0Ohgse_nP3DKNn219w7H97kQO--P3u7GfVWB2CI7mcXoowokFhxnZ66ymnuOKNRS-6IUqSpklpSlS52zmecWHbgobJJX3ld1WaQupQVQNPmXkEYIHUIFDxdrOpRtXUvZn81JUr01lcESURyEQMfKY7Xi_0KZgL9x2z9DNH_bpw3ub-f6__bibsC1nmiz7U4zbsKab27Bla705vw2fNpmtkVhxg2SbcdCmFqXooS1dbj1ZOwmjHY2WDh2NWVjirQKn2iPopzM2YwOmTG3jLy6Ax8vpFd3Yb1pG38fmLAqdwoZHeJAVomtSpXin9jKc69z7SPgw9Ab22dgp0IgX02IBEi16eBiEC4mwMWoCF4sfnPa5R85t_UbQtSiJeUOD1-0ky-mN0VG-DrLC6es4KV0iSprXmpeSyp9kKdSRrA5AMn0Bm1qliiK4OniMZoiGoWy8e1ZaJNRSkuOctzr4LuQJCXei-QzgnwF2Cuirj5pxich3bnmHOcYeQQvBxVYivXvV_Hg_F48gau7Rx8OzMHeaP8hbAjSUMrJyzdhfTY584_gsv0-G08nj4OKM_h80arxC3isiX4
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Jb9QwFLaqsohLWQuBAkaCE0QTO3biHBAqlBFV0WgOIHoziRcYCSXtzBQ0f41fx3vOMhqW3npAuWRxlJfke4vt5-8R8jQTleLey9hLXsWC2QR0ruCx9ym4J44cUzYUm8gnE3V8XEy3yM9-LQymVfY2MRhq2xgcIx9xCRsH9eQj36VFTA_Gr05OY6wghTOtfTmNFiJHbvUDum-Ll4cH8K-fcT5---HNu7irMBAbiFSWMfirAoIMBj01WxnFHANEKqFcUfJUFiJLytKm1prMMQPOnBcmySvnKl8WqU1xMBTM_6UcSctD2uB0GN9B5nUlRLdOJ0nVaCGCVcKcCA5OlsVywxeGkgF_i3P_TNf8bc42uMLx9f_5I94gO10ATvdbjblJtlx9i1xpS3KubpNP-9Q0IMyshiDc0pC-1lKX0MaHQ4dGcE5xxoOG5VgLOsMMrLCHcxflfEWXuPiM2nVG1h3y8ULeapds103t7hHKjcythEgPMCGqxFSlTOEhpnLMqVy5iLAeBtp0zOxYIOSbDhkCqdItdDRARwfoaBmR58M9Jy0vybmtXyO6hpbIKR5ONPMvujNRmjuf5YWVhrNS2ESWnpWKeYElEfJUiIjs9aDSnaFb6DWiIvJkuAwmCv9CWbvmLLTJkOqSgRx3WygPkqQYD0NQGpF8A-Qbom5eqWdfAw26Ygz6HnlEXvTqsBbr35_i_vlv8ZhcBY3Q7w8nRw_INY7KilS9bI9sL-dn7iG5bL4vZ4v5o6DtlHy-aM34BV6skjs
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+coordinated+progression+of+progenitor+cell+states+initiates+urinary+tract+development&rft.jtitle=Nature+communications&rft.au=Oraly+Sanchez-Ferras&rft.au=Alain+Pacis&rft.au=Maria+Sotiropoulou&rft.au=Yuhong+Zhang&rft.date=2021-05-11&rft.pub=Nature+Portfolio&rft.eissn=2041-1723&rft.volume=12&rft.issue=1&rft.spage=1&rft.epage=16&rft_id=info:doi/10.1038%2Fs41467-021-22931-5&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_2ef679d5c21a4d05af1a81f482877344
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon